No abstract available.
Lip

No abstract available.
Hemangioma* ; Vulva*

No abstract available.
Dermatitis, Atopic* ; Psoriasis*

No abstract available.
Adenoma* ; Toes*

No abstract available.
Lip* ; Neurofibroma*

Chondroid syringoma is an uncommon, benign and adnexal tumor which is composed of a mixture of epithelial cells and mesenchymal tissue. The usual presentation is of an asymptomatic, slowly growing mass, typically located in the head and neck region. We report a case of chondroid syringoma located in the right heel of a 46-year-old male patient. The tumor grew over a 10-year period, increasing rapidly in size over the last few months. It was a skin colored, 4.5x5x4 cm-sized, hyperkeratotic hard pedunculated nodule. The diagnosis of giant chondroid syringoma was made by clinical and histopathological examination, which showed a tubular structure and solid nest composed by more than two layers of epithelial cells embedded in a myxoid-adipoid tissue. The tubular lumina contained small amounts of amorphous, eosinophilic material. Regarding previous reports, this is a quite rare case of benign chondroid syringoma due to it's unusually large size and rare location.
Adenoma, Pleomorphic ; Eosinophils ; Epithelial Cells ; Head ; Heel ; Humans ; Male ; Middle Aged ; Neck ; Skin

Tinea incognito is a dermatophytosis of atypical clinical manifestation due to improper use of topical or systemic corticosteroids. We report two cases of tinea incognito misdiagnosed as eczema by non-dermatologist physicians. First, the lesions were manifested by pruritic, scaly localized erythematous macules and patches on the left ankle in a 61-year-old woman. She had been treated with topical steroids for 1 month without improvement. KOH smear revealed multiple fungal hyphae and histopathologic examination revealed the presence of fungal hyphae in the stratum corneum. Second, the lesions were manifested by localized scaly erythematous patches with pruritus on the face in a 76-year-old woman. She had been also treated with topical steroids for 2 months. KOH mount was positive for hyphae. All two patients were treated with 250 mg of terbinafine daily for 2 weeks and topical flutrimazole application. The lesions improved one month after treatment and no recurrence was observed.
Adrenal Cortex Hormones ; Aged ; Ankle ; Eczema* ; Female ; Humans ; Hyphae ; Middle Aged ; Pruritus ; Recurrence ; Steroids ; Tinea*

Erlotinib is a low-molecular-weight quinazoline derivative that inhibits the activation of epidermal growth factor receptor (EGFR) tyrosine kinase through competitive binding of the adenosine triphosphate binding domain of the receptor. Patients undergoing anti-EGFR therapy frequently present with cutaneous reactions like a sterile follicular and pustular rash, xerosis, pruritus, paronychia, hair abnormalities and mucositis, which can cause serious discomfort and negatively affect the compliance with anti-EGFR therapy. We report here on an interesting case of hair abnormalities induced by erlotinib (Tarceva(R)) and this presented as eyelash lengthening and hair curling in a 62-year-old woman.
Adenosine Triphosphate ; Binding, Competitive ; Compliance ; Exanthema ; Female ; Hair ; Humans ; Middle Aged ; Mucositis ; Paronychia ; Polyphosphates ; Protein-Tyrosine Kinases ; Pruritus ; Quinazolines ; Receptor, Epidermal Growth Factor ; Erlotinib Hydrochloride

A solitary fibrous tumor (SFT) is a relatively uncommon neoplasm that usually occurs in the pleura. However, SFTs are now known to affect various other anatomic sites as well, including rare examples in the skin. Cutaneous SFT is composed of uniformly spindled cells, which is classically described as a patternless feature. This tumor can mimic a variety of benign and malignant mesenchymal neoplasms. The first patient presented with a 3x3 cm sized subcutaneous nodule on the neck. Histopathologically, the biopsy specimen showed proliferation of spindle cells and epitheliod cells. Immunohistochemical stains for CD34, vimentin, bcl-2, and CD99 were strongly expressed. The second patient presented with a 1.5x1 cm sized subcutaneous nodule on the occipital area. The biopsy specimen was histopathologically consistent with SFT. Primary SFT developing on the skin is extremely rare, and only two cases have been reported in the Korean literature. SFT should be distinguished from primary spindle cell neoplasms of the skin.
Biopsy ; Coloring Agents ; Humans ; Hydrazines ; Neck ; Pleura ; Skin ; Solitary Fibrous Tumors ; Vimentin

BACKGROUND: Cases of dermatitis induced by the injection of certain drugs have been reported. OBJECTIVE: The aim of this study was to assess the cause and clinicopathologic findings of injection-induced dermatitis, and to reveal whether the reaction has any relation to the patient's age, injection site, drug concentration, and time interval from the injection to the occurrence of the skin lesion. METHODS: In this study, we enrolled 10 patients who developed erythematous skin lesions after the injection of causative drugs. The lesions were compared to each other according to the injection site, time interval from the injection to the occurrence of the skin lesion, and clinical characteristics. We performed intradermal and patch tests in each patient with different concentrations of causative drugs. RESULTS: The most common causative drugs were diclofenac and vitamin K1. The eczematous type was the most frequent clinical type. The intradermal test showed more positive results than the patch test. The patch tests with diclofenac (as is, 2.5%, 5%, and 10%) and vitamin K1 (10%) were all negative in 10 patients. Furthermore, intradermal tests with diclofenac (as is) and vitamin K1 (0.1%, 1%, and 10%) were performed in 8 patients. Six patients had a positive reaction, consisting of erythema, induration, and vesiculation, after 1 and 2 days. CONCLUSION: Our results showed that the most common causative agents were diclofenac and vitamin K1. Moreover, it seems that that intradermal test is more useful than the patch test in the diagnosis of injection-induced dermatitis.
Dermatitis* ; Diagnosis ; Diclofenac ; Erythema ; Humans ; Intradermal Tests ; Patch Tests ; Skin ; Vitamin K ; Vitamin K 1