No abstract available.
Adenoma* ; Toes*

No abstract available.
Hemangioma* ; Vulva*

No abstract available.
Lip

No abstract available.
Dermatitis, Atopic* ; Psoriasis*

No abstract available.
Lip* ; Neurofibroma*

BACKGROUND: Toll-like receptors (TLRs) are expressed by human epidermal keratinocytes and are involved in immune responses. OBJECTIVE: The goal of this was to investigate the expression of TLR2 in response to bacterial antigens, cytokines, and different calcium concentrations. METHODS: The expression of TLR2 was assessed after stimulation by lipoteichoic acid (LTA) and streptolysin O (SLO). In addition, TLR2 expression was evaluated after treatment with IFN-gamma and TNF-alpha, and different concentrations of calcium. The expression levels of TLR2 mRNA and protein were studied using RT-PCR and Western blot analysis. RESULTS: Cultured human epidermal keratinocytes constitutively expressed TLR2 and the expression was stimulated by LTA and SLO; in addition, IFN-gamma and TNF-alpha upregulated TLR2 expression. However, the changes in TLR2 expression associated with the calcium concentrations were insignificant. CONCLUSION: TLR2 expression increased with the concentration and duration of bacterial pathogens and this increase was amplified by several cytokines, from activated keratinocytes and other cells.
Antigens, Bacterial ; Bacterial Proteins ; Blotting, Western ; Calcium ; Cytokines ; Humans ; Keratinocytes ; Lipopolysaccharides ; RNA, Messenger ; Streptolysins ; Teichoic Acids ; Toll-Like Receptor 2 ; Toll-Like Receptors ; Tumor Necrosis Factor-alpha

Angioleiomyoma is a rare benign tumor arising from vascular smooth muscle which commonly develops on the lower extremities of middle-aged women. It is rare to occur on the fingers. Angioleiomyoma is classified into three histological subtypes; solid, venous and cavernous. The solid type is most common but the cavernous type is very rare. We report a case of a 53-year-old female with a digital cavernous angioleiomyoma. The patient had a 2-year history of an asymptomatic and slowly enlarging 1.3x1.0 cm-sized subcutaneous nodule on the distal phalanx of her second left finger. Histopathologic examination showed a well-demarcated nodular tumor in the dermis, which composed of numerous, dilated vessels and bundles of smooth muscle fibers.
Angiomyoma ; Caves ; Dermis ; Female ; Fingers ; Humans ; Lower Extremity ; Muscle, Smooth ; Muscle, Smooth, Vascular

Epithelioid blue nevus is a rare variant of blue nevus that has been recently described in patients with the Carney complex. However, sporadic cases have been reported even without the Carney complex. It typically presents as an asymptomatic, blue-gray, smooth-surfaced macule or papule occurring most often on the extremities and trunk. However, a few cases occurring on the mucosa have been reported. A 21-year-old man presented with a 0.4-cm sized solitary dark brownish or black papule on the lower lip. On histological examination, the major part of the specimen showed an infiltration of intensely pigmented epithelioid cells, the rest was composed of mildly pigmented spindle cells. There was no junctional activity, necrosis, or cellular atypia. These findings were consistent with epithelioid blue nevus. The patient did not exhibit any features associated with the Carney complex. No evidence of recurrence was observed during the follow-up period of 24 months. Herein, we report a rare case of epithelioid blue nevus arising on an unusual site.
Carney Complex ; Epithelioid Cells ; Extremities ; Follow-Up Studies ; Humans ; Lip* ; Mucous Membrane ; Necrosis ; Nevus, Blue* ; Recurrence ; Young Adult

No abstract available.
Hair*

Tinea incognito is a dermatophytosis of atypical clinical manifestation due to improper use of topical or systemic corticosteroids. We report two cases of tinea incognito misdiagnosed as eczema by non-dermatologist physicians. First, the lesions were manifested by pruritic, scaly localized erythematous macules and patches on the left ankle in a 61-year-old woman. She had been treated with topical steroids for 1 month without improvement. KOH smear revealed multiple fungal hyphae and histopathologic examination revealed the presence of fungal hyphae in the stratum corneum. Second, the lesions were manifested by localized scaly erythematous patches with pruritus on the face in a 76-year-old woman. She had been also treated with topical steroids for 2 months. KOH mount was positive for hyphae. All two patients were treated with 250 mg of terbinafine daily for 2 weeks and topical flutrimazole application. The lesions improved one month after treatment and no recurrence was observed.
Adrenal Cortex Hormones ; Aged ; Ankle ; Eczema* ; Female ; Humans ; Hyphae ; Middle Aged ; Pruritus ; Recurrence ; Steroids ; Tinea*