No abstract available.
Dermatitis, Atopic* ; Psoriasis*

No abstract available.
Lip

No abstract available.
Adenoma* ; Toes*

No abstract available.
Hemangioma* ; Vulva*

No abstract available.
Lip* ; Neurofibroma*

BACKGROUND: Frontal fibrosing alopecia (FFA), typically observed in elderly women, is characterized by a band of frontal or frontoparietal hair recession with scarring and a marked decrease, or a complete loss of the eyebrows. OBJECTIVE: To describe the clinical and histopathological features, and response to treatment of FFA in Korean patients. METHODS: A total of 7 female patients, diagnosed as FFA at our department from 2003 through 2006, were evaluated. RESULTS: All patients presented with a band of symmetric recession of the frontoparietal hairline. Four patients (57.1%) had symmetric loss of lateral eyebrows. Two patients (28.6%) were premenopausal. The histologic features were similar in all patients with a reduction of the number of hair follicles, and a perifollicular lymphocytic infiltration with lamellar fibrosis limited to the upper portions of the follicles. The progression of the condition stopped in all patients after topical steroid treatment. CONCLUSION: Cases of FFA affected in premenopausal female patients drove us to consider that this condition is not exclusive to postmenopausal females. To make a diagnosis of FFA, we should remind ourselves of the typical clinical and pathologic features. Further studies are necessary to confirm the possible role of treatment in FFA and stop the progression in the early stages of FFA.
Aged ; Alopecia ; Cicatrix ; Eyebrows ; Female ; Fibrosis ; Hair ; Hair Follicle ; Humans

Sweet syndrome is an acute febrile neutrophilic dermatosis predominantly characterized by fever, an elevated neutrophil count, and erythematous skin lesions comprising plaques and nodules that mainly appear on the upper extremities, face, and neck. The incidence of Sweet syndrome in the general population is unknown because of limited reports on this condition. Bortezomib, an antineoplastic agent that is the standard of care for multiple myeloma, has been reported to be associated with Sweet syndrome. We describe the case of a 66-year-old man who developed bortezomib-induced histiocytoid Sweet syndrome during treatment for multiple myeloma.
Aged ; Bortezomib ; Fever ; Humans ; Incidence ; Multiple Myeloma ; Neck ; Neutrophils ; Skin ; Standard of Care ; Sweet Syndrome* ; Upper Extremity

Lupus miliaris disseminatus faciei (LMDF) is a papulo-pustular eruption typically affecting the face of young adults. It is characterized histologically by the presence of caseating granuloma in the dermis. The lesions are typically described to affect the periorbital and muzzle skin of the face, however, only three cases with axillary involvement have been described in the literature. We report a case of LMDF on the face and left axilla of a 44-year-old female. She presented with a 7-month history of a mildly-pruritic papulopustular eruption on the face. The histologic examination showed the homogenous necrosis surrounded by granulomatous inflammation containing epithelioid macrophages, lymphocytes, and multinucleated giant cells in the dermis. Two months later, a solitary palpable nodule developed on the left axilla and its histological features showed similarity with the eruption on the face. A diagnosis of LMDF was made based on the clinical and histological findings. We hereby report an interesting and rare case of LMDF with axillary involvement.
Adult ; Axilla ; Dermis ; Diagnosis ; Female ; Giant Cells ; Granuloma ; Humans ; Inflammation ; Lymphocytes ; Macrophages ; Necrosis ; Skin ; Young Adult

Ceramides play major roles in maintaining the epidermal barrier. It has been sus-pected that the depletion of ceramides, associated with disrupted barrier function in the epidermis, leads to the clinical manifestation of dryness and inflammation seen in patients with psoriasis. The aim of the present study was to determine the relation-ship between the level of ceramide synthesis in the epidermis and the clinical severity in patients with psoriasis. Samples from lesional and unlesional epidermis obtained from psoriasis patients were incubated with [14C]serine, an initiator of ceramide syn-thesis. otal ceramide was fractionated using high performance thin layer chromato-graphy, and the radioactivity was measured. The clinical severity of psoriasis was graded according to the psoriasis area and severity index scoring system. The level of ceramide synthesis in the lesional epidermis of patients was significantly lower than that in the unlesional epidermis and bore a negative correlation with the clinical severity of psoriasis. The present results suggest that the decreased level of ceramide synthesis in the epidermis contributes to the clinical severity of psoriasis.
Adolescent ; Adult ; Biological Markers ; Ceramides/*metabolism ; Fatty Acids/*metabolism ; Female ; Humans ; Korea/epidemiology ; Male ; Psoriasis/classification/epidemiology/*metabolism/*pathology ; Severity of Illness Index ; Skin/*metabolism/*pathology ; Statistics

Peripheral T-cell lymphoma, unspecified (PTCL-U) is an infrequent type of non-Hodgkin's lymphoma (NHLs), which occurs mainly in adults. The common predilection sites is the peripheral lymph node; however, other sites, such as bone marrow, liver, spleen, and skin, may also be affected. PTCL-U and other types of PTCLs are the most aggressive types of the NHLs. Response to treatment is poor and the overall 5-year survival rates do not surpass 20%. A 57-year-old female presented with a 1-week-history of multiple and painful subcutaneous nodules. The shape and distribution of the nodules were similar to those of erythema nodosum. The histopathologic findings of the skin lesion fitted that described for PTCL-U. In spite of chemotherapy, she expired in 1 month after diagnosis.
Adult ; Bone Marrow ; Erythema Nodosum ; Female ; Humans ; Liver ; Lymphoma, Non-Hodgkin ; Lymphoma, T-Cell, Peripheral ; Middle Aged ; Skin ; Spleen ; Survival Rate