Objective: To study ginseng stem leaf saponin's effect on brain aging. Methods: The natural aging mice were adopted, divided randomly groups by weight and fed with ginseng stem leaf saponiu for three months, learning and memory ability of mice, the content of MDA and the action of MAO B of brain tissue were determined. The mice was fed with drugs for 40 days, the action of SOD and GSH Px of brain tissues were determined. Bissecting and fecthing the brain of the adult and aging rats and preparing brain chondriosomes and microsomes, and MDA content of brain chondriosomes and microsomes by the method of Fe 2+ cysteine inducing oxidation reduction reaction were determined. Results: Ginseng stem leaf saponin can increase learning and memory ability of aging mice, decrease the content of lipid peroxide and inhibit the action of MAO B of brain tissues; increase the action of SOD and GSH Px of brain tissues; and also inhibit the content of LPO induced oxidation reduction reaction by Fe 2+ cysteine in brain chondriosomes and microsomes of the adult and aging rats. Conclusion:Ginseng stem leaf saponin can protect brain function and postpone brain aging by decreasing free radical's damage and increasing action of GSH Px and SOD of brain tissue.

"Balance between yin and yang,the spirit is treated"means the best health state of the human body.The theory of yin and yang is the foundation of TCM theory,and the key to the treatment of chronic skin diseases is to regulate yin and yang.The key to the balance of yin and yang lies in the sufficiency of yang-qi.Sufficient yang-qi can guarantee the defense outside is solid and dense.The healthy-qi inside can avoid the invasion of pathogenesis.The invisible pathogenesis is difficult to transform into tangible pathogenesis.In the clinical syndromes,it has been found that the lack of yang-qi is one of the important reasons for the occurrence and development of skin diseases.By warming yang and dispersing pathogenic factors,dissolving muscles and dispelling wind,reconciling nutrient and defense,warming and dissipating cold,clearing heat and detoxifying,nourishing blood and moistening dryness,etc.,the deficiency yang can be warmed,the yang can be concealed,the balance between yin and yang can be achieved,and the diseases can be eliminated.

Objective To explore the expression of microRNA506 in brain tissue of mice with cere-bral ischemia reperfusion injury and its effect on proliferation and apoptosis of SH-SY5Y cells. Method-s Middle cerebral artery occlusion(MCAO)was used to establish the model of cerebral ischemia reperfu-sion in mice,and RT-PCR(reverse transcription polymerase chain reaction)was used to detect the expres-sion level of microRNA506 in the brain tissue of mice. MicroRNA506 overexpression plasmids and interfer-ence plasmids were constructed and transfected into SH-SY5Y cells respectively.Cell apoptosis was detected by flow cytometry,and cell proliferation was detected by MTT assay. Results The level of microRNA506 in brain tissue of cerebral ischemia reperfusion model mice was significantly higher than that of sham operation group((51.16±1.64)vs(12.82±1.66),P=0.008). The siRNA targeting microRNA506 significantly re-duced the growth of SH-SY5Y cells(P=0.0072),and induced the apoptosis of SH-SY5Y cells(P=0.0073). Transfection of microRNA506 enhanced the proliferation rate(P=0.020)of SH-SY5Y cells,and reduced the apoptosis of SH-SY5Y cells(P=0.017).Conclusions The expression level of microRNA506 in brain tissue of mice with cerebral ischemia reperfusion is increased.Overexpression of microRNA506 promotes the cell proliferation and decreases the apoptosis rate of SH-SY5Y cell while the low expression of microRNA506 de-creases the growth rate and induce cell apoptosis of SH-SY5Y cell.

Objective To investigate the effects of Atorvastatin on reducing the levels of inflammatory factors and on improving the quality of life in elderly patients with chronic kidney disease complicated with hyperlipidemia.Methods One hundred patients with chronic kidney disease accompanied with hyperlipidemia were enrolled from March 2016 to March 2017,and randomized into two groups:a control group undergoing conventional treatment with anticoagulant,diet control and standard glucocorticosteroid,and an observation group receiving Atorvastatin as add-on therapy to conventional treatment.Improvements of serum levels of inflammatory factors and blood lipid indices as well as total curative effect were compared between the two groups.Results The total effective rate was significantly higher in the observation group[94.0％ (47/50)]than in the control group (76.0％,38/50)(x2 =6.352,P＜0.05).After treatment,the improvements of blood lipid indices(TC,TG,LDL-C,HDL-C)were more in the observation group than in the control group(t =71.804,10.544,15.266,3.499,all P＜0.05).Before treatment,the serum levels of TNF-alpha,CRP and the 24h urine protein had no statistically significant differences between control and observation groups(P =0.406 or 0.678,respectively),but the levels in post-vs.pre-treatment were statistically significant lower in TNF-alpha[(1.1 ± 0.2) vs.(1.8 ± 0.3) μg/L],CRP [(8.2 ± 0.1) vs.(9.3 ± 0.1) mg/L] and 24h urine protein[(1.1±0.7)vs.(2.3±1.1)g/24 h](all P＜0.05).Conclusions Atorvastatin as add-on treatment to conventional therapy of chronic kidney diseases complicated with hyperlipidemia in the elderly has significant effects on controlling dyslipidemia and reducing inflammatory reactions so as to improve patients' quality of life.