1.Screening tools of dysphagia after stroke
Xinyan ZHANG ; Fuling YAN ; Yijing GUO ; Baoyu YUAN
International Journal of Cerebrovascular Diseases 2012;20(6):456-460
The incidence of dysphagia after stroke is high.It may affect the rehabilitation of patients and increase mortality.The assessment is of great significance for early objective examination of dysphagia,in which the bedside screening tests are the most common assessment methods in the routine clinical work.This article reviews the advances in research on the commonly used bedside screening tests of dysphagia.
2.Application of the calculated electrophysiological parameters in early diagnosis of carpal tunnel syndrome
Jin-Hua Zhang ; Baoyu Yuan ; Fu-Ling Yan
Neurology Asia 2020;25(2):139-143
Objective: To investigate the application of the calculated electrophysiological parameters in early
diagnosis of carpal tunnel syndrome (CTS). Methods: 44 patients (60 hands) with a diagnosis of
CTS and 31 healthy volunteers (44 hands) were enrolled. Acquired indicators include median nerve
distal motor latency (DML), complex muscle action potential (CMAP) amplitude, conduction velocity
(MCV), median nerve sensory nerve action potential (SNAP) amplitude, and conduction velocity
(SCV). Then the terminal latency index (TLI), the residual latency (RL), and the difference in peak
sensory latencies between the median and ulnar nerves (ΔPSL) were calculated. Results: The two
groups were matched in age and gender distribution. The CTS group showed significant difference
in SCV, DML, SNAP, and CMAP compared with the control group. The sensitivity, specificity, cutoff value, Youden index, and area under the curve of each indicator are respectively as follows: TLI
(0.733, 0.932, 0.622, 0.629, and 0.877), RL (0.750, 0.977, 1.334, 0.727, and 0.907), ΔPSL (0.950,
0.841, 0.150, 0.791, and 0.942), SCV (0.950, 0.796, 56.5, 0.746, and 0.946), DML (0.867, 0.932,
3.55, 0.799, and 0.930), SNAP (0.683, 0.932, 21.68, 0.615, and 0.844), and CMAP (0.683, 0.773,
8.76, 0.456, and 0.758).
Conclusion: The calculated electrophysiological parameters have higher sensitivities and specificities
relative to a single electrophysiological parameter, which could greatly improve the accuracy of early
diagnosis of CTS.
3.Human leptin gene overexpression enhances osteogenesis of bone marrow stromal cells from rats
Baoyu ZHENG ; Jun JIANG ; Yuling CHEN ; Minkui LIN ; Kai LUO ; Fuhua YAN
Basic & Clinical Medicine 2017;37(2):169-175
Objective To investigate the effects of human leptin ( hLEP) gene transfection on rat bone marrow stro-mal cells ( rBMSCs) .Methods rBMSCs were cultured and transfected with adenoviruses encoding hLEP ( Ad5-hLEP-EGFP) in vitro as experimental group while rBMSCs transfected with Ad 5-EGFP and non-transfected were control groups.The proliferation was detected by MTT and the expression of collagen type Ⅰ(Col-Ⅰ) and alkaline phosphatase ( ALP) were assessed by real-time PCR.The ability of mineralized nodule forming was also examined by Alizarin red staining .The combination of transfected rBMSCs and β-tricalcium phosphate (β-TCP ) was con-structed and the osteogenic ability of the construction was evaluated in nude mice .Results hLEP could be trans-fected into rBMSCs successfully by adenovirous .After transfection , the proliferation was not affected while Col-Ⅰand ALP expressions were more pronounced in rBMSCs transfected with Ad 5-hLEP-EGFP ( P<0.05 ) .Alizarin red staining showed the ability of mineralized nodule forming was also up-regulated in Ad5-hLEP-EGFP group (P<0.05).In addition, the transfected rBMSCs adhered to β-TCP and survived well and the combination showed more new bone like tissue formation in nude mice compared to control groups .Conclusions rBMSCs transfected with hLEP might be potently used in bone or periodontal tissue regeneration .
4.The study of the relapsed patients with major depressive disorder based on spectral dynamic causal modeling
Jiaming LI ; Baojuan LI ; Kaizhong ZHENG ; Liang LI ; Peng DU ; Baoyu YAN
Journal of Practical Radiology 2018;34(6):824-827
Objective To explore the effects of abnormal effective connectivity within the default mode network (DMN)in relapsed patients with major depressive disorder.Methods Resting-state functional magnetic resonance imaging (rs-fMRI)data were collected from 21 patients of first-episode depression and 16 patients with relapsed depression,and 37 matched healthy controls.The effective connectivity within the DMN was investigated with spectral dynamic causal modeling (spDCM)method.Results spDCM analysis showed that the effective connections from left parietal cortex(LPC)to right parietal cortex(RPC)and medial frontal cortex(mPFC)were significantly decreased,while the connection from posterior cingulate cortex(PCC)to mPFC was increased in patients of first episode depression compared to healthy controls.Furthermore,the connectivity between mPFC and LPC were enhanced in patients with recurrent depression compared withhealthy control subjects,as well as PCC.Meanwhile,the connectivity between mPFC and PCC was enhanced in patients with relapse depression compared with patients of first episode depression.Conclusion Both first-episode and relapsed patients demonstrated abnormal effective connectivity of LPC,implicating that abnormal LPC connectivity may be associated with the neural substrates of depression.In contrast,the patients with relapsed depression showed aberrant connectivity with the mPFC,suggesting that abnormal effective connectivity of the mPFC may play an important role in the relapse of depression.
5.Correlation between monocytes and high-density lipoprotein cholesterol ratio and coronary artery stenosis in patients with unstable angina pectoris
Zejiaxin NIU ; Dan WANG ; Guilin HU ; Mingke CHANG ; Tongshuai GUO ; Yu YAN ; Baoyu GAN ; Hui LIU ; Jianjun MU
Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(1):14-21
【Objective】 To investigate the correlation of monocytes and high-density lipoprotein cholesterol ratio(MHR) and albumin with the severity of coronary artery lesions in patients with unstable angina pectoris. 【Methods】 We enrolled 342 patients with unstable angina pectoris. According to the Gensini score of their coronary angiography results, they were divided into Gensini≤ 20 group, 20