Objective To investigate the relationship between second-hand smoke exposure and lung cancer death trend in Huizhou area. Methods The corresponding records of lung cancer in the tumor registration system in Huizhou area from January 2019 to December 2019 were collected to investigate the subjects' second-hand smoke exposure. Linear regression model was used to analyze the correlation between the mortality of lung cancer patients and the second-hand smoke exposure rate. Logistic regression model was used to analyze the correlation between second-hand smoke exposure and death of lung cancer patients. Results In 2019, the mortality rate of lung cancer patients in Huizhou was the highest in the third quarter, and the second-hand smoke exposure rate of lung cancer patients was also the highest in the third quarter. The mortality rate of lung cancer patients in Huizhou was significantly positively correlated with the second-hand smoke exposure rate (r2 = 0.985 9, P<0.05). The second-hand smoke exposure rate, second-hand smoke exposure concentration, and the extent of second-hand smoke environmental enclosure of dead cancer patients were significantly higher than those of lung cancer patients in the survival group, and the difference was statistically significant (P<0.05). The second-hand smoke exposure, second-hand smoke concentration and the extent of the enclosure of second-hand smoke environment were independent risk factors influencing the death of lung cancer patients (P<0.05). Conclusion The trend of lung cancer deaths in Huizhou in 2019 was consistent with the prevalence of second-hand smoke exposure. The second-hand smoke exposure is an important factor for lung cancer deaths.

Objective: To investigate the association between the preterm birth and low birth weight and parental thalassemia. Methods: Pregnant women and their husbands receiving prenatal examination in local hospitals or maternal and child health centers in Jingxi and Debao in Guangxi from January to December 2017 were selected as study subjects. A total of 758 pregnant women with pregnancy outcomes and their husbands, who were both or alone diagnosed with thalassemia through thalassemia gene detection, were selected as case group and 758 pregnant women with pregnancy outcomes and their husbands, who were negative in thalassemia gene detection and hemoglobin electrophoresis test were selected as control groups. The case group were further divided into mother group, father group and both mother and farther group. Clinical and pregnancy outcome data of the study subjects were collected for the analysis on the association between parental thalassaemia and preterm birth or low birth weight by the independent sample t test, χ² test and Cox regression analysis. Results: The incidence of preterm birth in case group and control group was about 6.5% and 1.6% and the incidence of low birth weight in case group and control group was about 7.3% and 0.8%. After adjusting for possible confounding factors, Cox regression analysis results showed that mother suffering from thalassemia (aRR=3.45, 95%CI: 1.35-8.81, P=0.010), fathers suffering from thalassemia (aRR=4.93, 95%CI: 2.16-11.21, P<0.001) and both mother and farther suffering from thalassemia (aRR=5.13, 95%CI: 2.62-10.04, P<0.001) were associated with preterm birth. Mother suffering from thalassemia (aRR=12.98, 95%CI: 4.91-34.30, P<0.001), fathers suffering from thalassemia (aRR=9.40, 95%CI: 3.40-25.95, P<0.001) and both mother and farther suffering from thalassemia (aRR=10.74, 95%CI: 4.44-26.00, P<0.001) were associated with low birth weight. The newborn whose parent all suffered from thalassemia had higher risks for preterm birth (χ²=22.72, P<0.001)and low birth weight (χ²=34.03, P<0.001) compared with those only with mother or father suffering from thalassemia. Conclusion Parental thalassaemia, including both sides and single side, might increase the risks of preterm birth and low birth weight for newborn, and the risks might be higher in newborn with both mother and father suffering from thalassaemia.