OBJECTIVE To evaluate the affection to heart rate, blood pressure and breathing rate by nasal packing versus transseptal suturing techniques during patients undergone septoplasty. METHODS Eighty patients with deviation of nasal septum were included in this study. The patients were allocated into two groups: packing group and suturing group. The heart rates, blood pressure and breathing rates pre-and post-operations were collected, and the ascending range of these between two groups were assessed. The post-operative complications were observed. RESULTS The ascending range of the heart rates, blood pressure and breathing rates were smaller in suturing group than in packing group patients(P ＜0.05). There is no significant differences in post-operative complications between 2 groups. CONCLUSION Nasal suturing techniques during septoplasty might be a valid substitution for packing with more stable vital signs, smaller burden on the cardiovascular system and the same complication rates.