Objective To investigate the expression of tumor metastasis associated protein I (MTA1) in esophageal cancer tissue and its relationship with clinicopathological features and 3-year survival rate.Methods Ninety-six postoperative pathological samples of esophageal cancer and 40 samples of paracancerous tissue conforming to the inclusion standard collected by the pathological department of this hospital from January 2010 to December 2012 were selected and performed the immunohistochemical staining.Then the relationship between MTA1 protein expression with the clinicopathological features and long term survival rate was analyzed.Results The MTA1 protein expression rate in the esophageal cancer tissueswas 73.96％,which was significantly higher than 2.50％ in paracancerous tissues (P＜0.05);esophageal cancer tissues MTA1 protein expression mainly had significant correlation with TNM stage and lymph node metastasis(P＜0.05);the 3-year survival rate in the patients with esophageal cancer tissue MTA1 protein positive expression was 33.80 ％,which was significantly lower than 60.00 ％ in the patients with MTA1 protein negative expression (P＜0.05);the long-term survival rate in the patients with esophageal cancer had significant relationship with TNM staging and MTA1 protein expression (OR=1.638,OR=1.433,P＜0.05).Conclusion MTA1 protein is highly expressed in esophageal cancer tissue,and has the relationship with TNM stage and lymph node metastasis,MTA1 protein high expression is an independent risk factor for the prognosis in the patients with esophageal cancer.

Methods:From Jan 2019 to Nov 2021, 20 patients underwent 3D printed template assisted pre-fenestration of stent graft with reducing-diameter tie technique and branched stents for the EVAR at the three hospitals. The clinical data patients were collected and analyzed.Results:All the 20 cases underwent 3D printed template assisted pre-fenestration of stent graft according to the data of pre-operative the computed tomographic angiography (CTA). EVAR was successfully performed in all patients(included 2 cases with one fenestration,5 cases with 2 fenestration,10 cases with 3 fenestration and 3 cases with 4 fenestration). Fifty-four reinforced fenestrations (20 in right renal artery, 18 in left renal artery, 13 in superior mesenteric artery and 3 in celiac artery) were performed. During the follow-up period (mean 14.6 months), 1 case died, and the one-stage patency rate of splanchnic artery branch stent was 98.1%. Four patients had endoleak, 1 patient died of intracranial hemorrhage during postoperative period. None of patients had postoperative paraplegia or organ ischemia.Conclusions:3D printed template assisted pre-fenestration of stent graft with reducing-diameter tie technique is feasible for EVAR in the treatment of complex abdominal aortic aneurysms and dissections. The technique is capable to reinforce the blood supply of visceral arteries with satisfied short-term effectiveness.Ojective:To evaluate 3D printed template assisted pre-fenestration of stent graft with reducing-diameter tie technique and branched stents for the endovascular aortic aneurysm repair (EVAR).