Acupuncture Points ; Acupuncture Therapy ; Aged ; Humans ; Male ; Pancreatic Neoplasms ; therapy

In order to improve the clinical efficacy of the umbilicus fumigation method, the ancient literature with the heat control of umbilicus fumigation method involved is collected extensively and analyzed systematically, and the heat control, precautions and contraindications of this method are discussed. In association with the cases and the present clinical experience, the main factors to the heat control are introduced, such as preparation of doughnuts, filling quantity, size of moxa cone and numbers of moxa cones so that the clinical application of the umbilicus fumigation method can be promoted and enhanced.
Biomedical Research ; China ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; Fumigation ; History, Ancient ; Hot Temperature ; Humans ; Medicine in Literature ; Medicine, Chinese Traditional ; history ; methods ; Umbilicus ; physiopathology

Objective To discuss the relationship between GULP1 gene polymorphism of Chinese Han population and schizophrenia,cognitive function.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to detect 86 patients with schizophrenia and 72 normal controls GULP1 gene SNPrs2004888 polymorphism;Wechsler Memory Scale(WMS) and Wisconsin Card Sorting Test(WCST) assessment of two groups of memory and executive function,and assessed with the PANSS scale clinical symptoms.Results The differences of GULP1 gene SNP(rs2004888) polymorphism genotype and allele frequency was statistically significant (χ2 = 35.71、32.21,all P＜0.05).Genotypes in patients with group comparison of cognitive function between groups showed the genotype groups Wechsler Memory Scale Logical Memory scores were significant(P＜0.05),G/G and T/T genotype compared with the Wisconsin Card Sorting Test in the number of errors,error numbers and classification numbers significant(P＜0.05).Conclusion GULP1 gene SNPrs2004888 polymorphism was associated with schizophrenia,and also related to cognitive function in schizophrenia.

OBJECTIVETo study the characteristics of low bone mass in amenorrhea patients with elevated follicular stimulating hormone (FSH).

METHODSAmenorrhea patients with elevated FSH: Primary amenorrhea 18 cases, secondary amenorrhea 171 cases and age matched controls with normal menstruation, 180 cases. The descriptive parameters were: estrogen, alkaline phosphatase, urinary excretion of calcium to creatine ratio, cortical bone mineral density at the right radius measured by single photon absorptiometry and trabecular bone mineral density at the lumbar vertebra body measured by quantitative computerized tomography.

RESULTSAverage E(2) levels in amenorrhea patients is under 150 pmol/L with significantly higher alkaline phosphatase and urine calcium to creatine ratio values than the normal menstruation group. Cortical bone mineral density in the secondary amenorrhea group (655 +/- 69 mg/cm(2)) was significantly lower than that of the normal menstruation group (677 +/- 56 mg/cm(2), P < 0.01). Trabecular bone mineral density in the secondary amenorrhea group (145 +/- 26 mg/cm(3)) was significantly lower than that of the NOR group (192 +/- 28 mg/cm(3), P < 0.001). The disparity with the normal menstruation group is even greater in the primary amenorrhea group. Bone mineral density of the amenorrhea patients was negatively correlated with duration of the menopause.

CONCLUSIONSSerum estrodiol levels in amenorrhea patients was so low that bone turnover was accelerated. This led to insufficient bone accumulation and a dramatically drop in trabecular bone mineral density. The extent was closely related to age of onset of amenorrhea and the duration of ovarian failure.

Adult ; Age Factors ; Amenorrhea ; blood ; metabolism ; Bone Density ; Bone and Bones ; metabolism ; Estradiol ; blood ; Female ; Follicle Stimulating Hormone ; blood ; Humans ; Menopause ; Middle Aged