Objective To investigate the effects of leuprolide acetate microspheres (Evan Bayh) in the treatment of adenomyosis with infertility by IVF-ET.Methods From January 2012 to May 2016 ,122 cases of adenomyosis combined with infertility were selected in the reproductive medicine center of the hospital as the research subjects ,all the patients were randomly divided into experimental group and control group with 61 patients in each group according to the order of admission ,the experimental group was received injection of Evan Bayh ,the control group was given injection of triptorelin acetate treatment ,and then all patients were given the in IVF-ET treatment ,investigation and prognosis.Results The dosage of gonadotropins(Gn) in the experimental group was less than that in the control group ,and the use time of Gn was lower than that of the control group ,and the differences between the two groups were statistically significant (P＜0.05).The lutein-izing hormone(LH) in the experimental group was significantly higher than that in the control group at the human chorionic gonadotropin(HCG) injection time ,while the estradiol(E2) ,progesterone(P) and endometri-um thickness were significantly lower than those of the control group (P＜ 0.05).The number of retrieved eggs and the number of transplantable embryos in experimental group were lower than those in control group (P＜0.05) ,the rate of cycle cancellation was higher than that of control group (P＜0.05) ,and there was no significant difference in clinical pregnancy rate compared between the two groups (P＞0.05).Conclusion The application of Evan Bayh in adenomyosis combined with infertility patients in the treatment of IVF-ET can re-duce the dose of Gn and the use of time ,promote normal hormone secretion ,improve the patient's oocyte num-ber ,the number of embryos ,reduce the cycle cancellation rate ,and has good application value.