Inflammatory bowel disease (IBD) is a non⁃specific chronic inflammatory disease of the intestine, and its pathogenesis is not yet been fully elucidated. At present, it is generally believed that gut microbiota plays a key role in the pathogenesis of IBD. Prebiotics are non⁃digestible food ingredients that can regulate the gut microbiota. Recently, more and more studies support the beneficial effect of prebiotics in IBD. Some prebiotics of dietary supplements can be used as fermentable substrates to promote the growth and metabolic activity of intestinal beneficial bacteria and increase the production of short ⁃ chain fatty acids, thereby exerting anti ⁃ inflammatory effects. This article reviewed the progress in research on the protective mechanism of prebiotics in IBD from the perspective of traditional and emerging prebiotics and providing a theoretical basis for its application in IBD adjuvant therapy.

Objective To investigate the clinical features of patients with allergic reactions induced by hepatic arterial perfusion chemotherapy,and to discuss its nursing strategy.Methods The clinical manifestations,severity grading,time of onset,high-risk drugs,and the initial symptom of anaphylactic shock in 82 patients with allergic reactions were analyzed.Results Of the 82 patients,57(69.5％)had liver metastases from colorectal cancer,aged 42-82 years.Most patients(98.8％)were allergic to oxaliplatin.Degree I allergic reaction was most commonly seen(80.5％),and the clinical manifestations were mainly skin symptoms.Multiple symptoms could occur at the same time.The allergic reactions could occur in various time periods of medication,and anaphylactic shock usually occurred within 30 min after medication,and the initial symptom was atypical.Conclusion Oxaliplatin is a common drug that may cause allergic reactions in patients receiving hepatic artery infusion chemotherapy.Nursing staff should be familiar with the relevant drug allergic reactions,especially the clinical symptoms,features,and nursing measures of anaphylactic shock,so as to ensure the safety of patients.(J Intervent Radiol,2023,32:1242-1245)