Objective To compare the clinical effect of first-line chemotherapy containing oxaliplatin on left and right colon cancer.Methods A total of 120 patients with colon cancer admitted to Second Affiliated Hospital of Shanghai University from January 2020 to January 2024 were selected and divided into left colon cancer group(60 cases)and right colon cancer group(60 cases)according to tumor location.Both groups were treated with first-line chemotherapy containing oxaliplatin for 2 cycles.Disease control rate,serum tumor markers,serum inflammatory factors,cancer-causing symptom scores,quality of life and incidence of adverse reactions were compared between two groups.Results After treatment,disease control rate in left colon cancer group was significantly higher than that in right colon cancer group(x2=22.224,P＜0.00 1).The levels of serum carcinoembryonic antigen,carbohydrate antigen 125,carbohydrate antigen 153,C-reactive protein and interleukin-6 of left colon cancer group were lower than those of right colon cancer group(P＜0.05).The scores of cancer-related pain and fatigue of left colon cancer group were lower than those of right colon cancer group(P＜0.05).The quality of life in left colon cancer group was better than that in right colon cancer group(P＜0.05).Conclusion First-line chemotherapy containing oxaliplatin has better short-term efficacy in patients with left colon cancer,with better control of tumor progression,and can improre clinical symptoms and quality of life.