Objective:To compare the differences of cranial base morphology between high-angle and low-angle malocclusion patients with geometric morphometrics.Methods:Pretreatment lateral cephalograps of 80 skeletal Class I patients(40 hypodivergent,40 hyperdivergent)were selected.All cephalographs were scanned,and 13 homologous landmarks of cranial base were identified and digitized.Average geometries of cranial bas e were created by means of Procrustes analysis.Thin-plate spline analysis was applied to cranial base configurations to determine local morphology differences between the two vertical facial types.Results:1.high-angle patients had the cranial base characteristics as follow:(1)Horizontal and vertical expansion occured in the sphenoida region,(2)The anterial and posterior cranial bases circled S point opposite direction revolving,which caused cranial base angle to reduce significantly.2.The low-angle the cranial base characteristics was just opposite with high-angle′s.Conclusion:The shape of cranial base was different between high-angle and low-angle malocclusion patients.

BACKGROUND:MATLAB has capabilities of large numerical calculation, mathematical drawing and simple finite element analysis. It can establish models rapidly and can be able to identify the grayscale with BMP and JPG
format, and it can directly transform the identified data into ANSYS finite element software-readable format, thus avoiding personal error produced by the repositioning and secondary treatment in the Autocad software.
OBJECTIVE:To find a simple, convenient and accurate method to construct the model of lumber fusion and to analyze the biomechanics of lumbar motion segment after lumbar fusion.
METHODS:Lamel ar CT and Matlab (Matrix Laboratory) scientific computing software combining Ansys finite
element software was used to construct the models of lumber fusion. Then the models were loaded to analyze the biomechanical change of the fusion model.
RESULTS AND CONCLUSION:The established models were loaded with axial, bending and stretching loads, and the biomechanical analysis showed that interbody fusion had the best stability among al the fusion models. Combined with joint fusion, the axial displacements of interbody, rear side and rear fusion models were
decreased by 5%, 1%and 4%than that of simple interbody fusion, posterolateral fusion and posterior fusion models. Under the stretch-buckling load conditions, the rotation angles were reduced by 23%, 11%and 45%. Stress concentration to the fusion parts showed fusion block could increase the load displacement. The
technology of lamel ar CT, Matlab software and Ansys finite element software can accelerate the construction of lumber fusion model and make the model more accurate. Facet joint fusion combined with interbody fusion,
posterolateral fusion and posterior fusion can get better lumbar stability, and this increased stability is more significant in the rear fusion. Stress distribution of posterior fusion is more reasonable.

Objective To improve the nutritional knowledge and dietary habit of medical students in Lanzhou region for their health.Methods A self-designed survey of nutritional knowledge,attitude,and practice(KAP)was made on 329 medical students in Lanzhou region,with a subsequent nutritional education given to 195 volunteers in the form of lectures,consulting,publicizing materials issuing,among other things.An analysis was made on the effect of the nutritional education using the relevant KAP's self-comparision prior and subsequent to the nutritional education and using the students' response to the nutritional education.Results Before the education,the students in question scored 42.27?8.29 on knowledge,14.29?1.93 on attitude,and 16.39?2.17 on practice.After the education,the three scores rose to 46.52?6.78,15.20?0.98,and 18.39?2.17 respectively,and the students tended to acquire nutritional knowledge through ways of more variety.Their correct dietary practice increased by 15.75%.Their demand for nutritional knowledge became increasingly diversified,a case of which was that their demand for prevention knowledge of malnutrition rose by 20.75%.Through the education,the students in question had an obvious change in their dietary knowledge,attitude,and practice.Conclusions Giving nutritional knowledge education to the medical students in Lanzhou region in a flexible way has a good effect.Their healthful dietary practice should be intensified simultaneously with the improvement of their nutritional knowledge.

Adult ; Humans ; Humeral Fractures ; diagnosis ; surgery ; Male ; Shoulder Dislocation ; diagnosis ; surgery

Objective To study the epidemical characteristics of influenza in Gansu province from 2009 to 2012,and to discuss the changes of the predominant strains of influenza virus.In order to provide scientific basis for defending influenza effectively.Methods Influenza surveillance was performed by collecting the pharyngeal swab specimens from influenza patients of national surveillance hospitals and places with suspected influenza epidemic situations,inoculated on MDCK cell culture to obtain the influenza virus strains.Results From Jan.2009 to Dce.2012 36892 specimens were collected,and 8030 were positive for influenza virus,including 4331 influenza A (H1 N1),seasonal H3N2 subtype1562,H1N1 subtype 96,1651 type B,and 380 type A with unknown subtype strains.During the period from 2009 to 2012,the positive of influenza virus isolation was 32.71％,13.95％,7.80％,and 19.64％,respectively.Totally 1149 influenza virus strains were isolated,positive rate was 16.24％,of them,346 strains were SWA1 (H1pdmN1),34 strains were A1 (H1N1),183 strains were A3 (H3N2),470 strains were subtype B of Victoria and 116 strains were subtype B of Yamagata.Conclusion In 2009 new influenza A (H1N1) was the major epidemic,and in 2010-2011 the activity of influenza was very weak,only presented as sporadic disease.In the spring of 2012,type B influenza was dominant,while since Nov.type A (H1N1) and seasonal H3 were dominant.There was a peak of influenza epidemic each year,and alternative viral types predominance was the rule.

Objective To offer a scientific basis for the influenza prevention and control,we analysed the influenza (flu) characteristics of Gansu province during the year of 2013 to 2015.Methods We detected the samples of flu virus,which collected from the throat swabs of outpatients with influenza-like illness (ILI) in the 19 national influenza surveillance sentinel hospitals of the Gansu province,by fluorescence quantitative PCR technique,the positive specimens were used to isolate and identify the virus with the canine kidney cells (MDCK).Results After the influenza virus nucleic acid detections of 37 332 ILI throat swabs,we got 5 928 positive samples,and the positive rate was 15.88％.From the 14 th week of 2013 to the 13th week of 2016,the positive rates of the influenza virus nucleic acid were in turn as following:14.52％,12.36％ and 20.15％ respectively.According to age groups,the results showed that the lowest positive rate of 12.78％ was from the babies below 5 years old,which was significantly lower than that of the other age groups.The highest positive rate of 24.75％ was came from the group of 15-24 years old.1 630 influenza virus was isolated from 6 285 specimens,the positive rate was 25.93％,which including395 A (H1N1),524 seasonal H3N2,342 B Victorian virus and 367 B Yamagata virus.Conclusions The epidemic types of influenza virus in Gansu province perform in the rule of alternative spreading.So it is necessary to take active measures to prevent and control human infection with the influenza virus.

Objective:To analyze the genomic characteristics of human infection with H9N2 avian influenza virus in Gansu province.Methods:The etiological analysis was conducted for human infection with H9N2 avian influenza virus detected in influenza like illness cases in northwestern China in 2016. Molecular bioinformatics Mega 7.0 software was used to analyze the full genomic sequences of the viral isolate.Results:The gene fragments of HA, NA, MP, NP, NS, PA, PB1 and PB2 of the isolate were highly similar (>90%) to those of H9N2 avian influenza virus strain isolated in external environment in Gansu from 2014 to 2019. The HA gene belonged to BJ/94-like branch, PB2 and MP belonged to G1/97-like branch, and the PB1, PA, NS, and NP genes belonged to F/98-like branch. MP and PB2 were closely related to H7N9, H10N8 and H5N6 viruses. Amino acid sequence alignment showed that the HA cleavage site was arranged in PSRSSR ↓ GLF, H183N and Q226L mutated which included 7 HA glycosylated sites; 62-64 sites of NA absented 3 amino acids (ITE); and M2-31N, NS1-42S, PA-356R, and PA-409N mutated.Conclusions:Apparently, this case of human infection with human infection with H9N2 avian influenza virus was an incidental. However, the isolates of H9N2 influenza virus in external environment of Gansu had a series of mammalian adaptive molecular markers, suggesting that the risk of human infection is higher. It is necessary to strengthen the surveillance by multi departments to deal with influenza pandemic.

Objective:To analyze the influenza surveillance results and epidemiological characteristics of the disease in Gansu province in 2010-2018, and provide scientific basis for the formulation and adjustment of influenza prevention and control strategies.Methods:Real-time PCR was used to detect the specimens of ILI illness (ILI) cases reported by 19 national influenza surveillance sentinel hospitals in Gansu province. Influenza virus isolation and culture were carried out using canine kidney cells (MDCK).Results:Total of 93 334 specimens from ILI cases were collected from Jan. 2010 to Dec. 2018, and 13 439 samples were positive for influenza virus nucleic acid. The positive rate of viral nucleic acid detection was 14.40%, and the proportion of influenza B virus in positive samples was the highest (37.02%), and seasonal H3N2 influenza virus (35.25%), H1N1 influenza virus (26.78%). The advantages are different in various periods. The peak period of influenza is from Dec. to Mar., and the highest incidence rate is in the age group of 5-15 years (20.34%). The incidence rates of the other age groups are similar. The difference of influenza positive rate in different age groups is statistically significant ( χ2=775.153, P<0.001), but in male and female was not significant. Total of 16 101 ILI specimens positive for influenza virus nucleic acid were subjected to virus isolation and cultured, and 3 892 strains of influenza virus were isolated, of which influenza B virus accounted for the highest proportion (37.82%), followed by seasonal H3N2 influenza virus (33.04%), H1N1 influenza virus (28.96%). Conclusions:The epidemic of influenza in Gansu province had an obvious regularity, and it was undulating and prevalent. It is necessary to strengthen prevention and control measures among school-age children and adolescents.

Objective:To investigate the effects of mobile intelligent cognitive training(MICT)on cognitive function,ac-tivities of daily living,and quality of life of patients with mild to moderate cognitive impairment after stroke in the community. Method:Ninty-two patients with mild to moderate cognitive impairment after stroke in the community were randomly divided into experimental group(n=46)and control group(n=46).Both groups received comprehen-sive management,and the experimental group received additional MICT for 12 weeks.The Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),Prospective and Retrospective Memory Ques-tionnaire(PRMQ),Modified Barthel Index(MBI),Functional Activities Questionnaire(FAQ),and Quality of Life Index(QLI)were assessed before,4 weeks and 8 weeks after treatment,and 1-month follow-up after the end of treatment. Result:Before treatment,there was no significant difference in all scores between the two groups(P＞0.05).After 6 weeks of treatment,the MMSE,PRMQ,MBI,FAQ,and QLI scores of the two groups were im-proved(P＜0.05),and the MoCA,MBI,and QLI scores of the experimental group were higher than those of the control group(P＜0.05);After 12 weeks of treatment and 1 month of follow-up,the scores of MMSE,MoCA,PRMQ,MBI,FAQ,and QLI were significantly improved in two groups(P＜0.05),and all scores of the experimental group were better than those of the control group(P＜0.05). Conclusion:MICT can improve cognitive function,activities of daily living,and quality of life in patients with mild to moderate cognitive impairment after stroke in the community,with efficacy lasting at least 1 month.

Objective:To analyze the antigenicity and genetic characteristics of two strains of Eurasian avian H1N1 swine influenza virus (EAS-H1N1) isolated from 2 human cases found in Gansu province to provide scientific reference for disease prevention and control.Methods:Two cases of human infection with EAS-H1N1 discovered in Gansu province since February 2021 were analyzed for antigenicity and genome comparison, and their genome characteristics were analyzed using software such as Mega7.0.Results:Two human infections with EAS-H1N1 had related environmental exposure history. Two strains were obtained: A/Gansu-Xifeng/1143/2021 and A/Gansu-Xifeng/1194/2021. The two strains of HA, NA genes were all from the Eurasian avian H1N1 swine influenza virus, and are closely related to the human infection EAS-H1N1 virus in Hebei and Tianjin and the EAS-H1N1 virus isolated from the mink in Shandong; the HA receptor binding sites of 2 strains E190D and D225E mutations occurred in all spots, and there were no H274Y and N294S mutations in NA protein.Conclusions:Some important molecular mutations occurred in the genome of people infected with EAS-H1N1 virus in Gansu province, which may lead to increased virulence and potential human-to-human transmission. Strengthening the research and analysis of EAS-H1N1 gene characteristics will help to monitor the mutation and mutation of the virus at the molecular level and scientifically prevent and control the epidemic.