1.A study on the effects of compound oil of semen spinosa, semen orientalis, and jasminoides on soothing nerves and improving mental capacities in mice.
Feng GAO ; Zhao-Ying FU ; Bao-Li LI
Chinese Journal of Applied Physiology 2011;27(2):240-245
Animals
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Drugs, Chinese Herbal
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pharmacology
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Female
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Gardenia
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chemistry
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Memory
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drug effects
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Mice
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Mice, Inbred ICR
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Motor Activity
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drug effects
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Plant Oils
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pharmacology
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Seeds
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chemistry
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Ziziphus
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chemistry
3.Microvascular density and VEGF expression in hepatocellular carcinoma after arterial chemoembolization.
Ying BAO ; Wen-ming FENG ; Mao-yun FEI
Chinese Journal of Oncology 2010;32(10):770-771
Angiogenesis Inhibitors
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therapeutic use
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Carcinoma, Hepatocellular
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blood supply
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metabolism
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pathology
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therapy
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Chemoembolization, Therapeutic
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methods
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Endostatins
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therapeutic use
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Humans
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Liver Neoplasms
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blood supply
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metabolism
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pathology
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therapy
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Microvessels
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pathology
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Neovascularization, Pathologic
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pathology
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Vascular Endothelial Growth Factors
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metabolism
4.Effects of metformin on the levels of serum retinol-binding protein 4 and inflammatory factors in patients with impaired glucose tolerance and metabolic syndrome
Peng LIU ; Ying-ying CHEN ; Feng-mei ZHANG ; De-bao WANG ;
Chinese Journal of Postgraduates of Medicine 2011;34(25):32-35
ObjectiveTo investigate the effects of mefformin on the levels of serum retinol-binding protein 4 (RBP-4),high sensitive C reactive protein (hs-CRP) and tumor necrosis factorα (TNF-α) in patients with impaired glucose tolerance(IGT) and metabolic syndrome(MS). MethodsSixty patients with IGT and MS were divided into mefformin treatment group (30 cases) and life-style intervention group (30 cases) by random digits table. Body mass index (BMI),the levels of HbAic, HOMA-IR, blood fat, RBP-4,hs-CRP, TNF- α were measured both before and 16 weeks after treatment in the two groups and compared.ResultsThe levels of HbA1c, HOMA-IR, RBP-4, hs-CRP and TNF- α were significantly lower in mefformin treatment group than those in life-style intervention group [(5.09 + 0.26 )% vs. (5.69 ± 0.49 )%, 2.95 ± 0.63vs. 3.49 ± 0.78, ( 18.69 ± 6.50) mg/L vs.(26.20 ± 6.97) mg/L, (2.37 ± 0.53) mg/L vs.(2.99 ± 0.57) mg/L,(9.49 ± 2.37) μ g/L vs. ( 14.33 ± 2.62) μ g/L] (P < 0.01 ). The results of multiple linear regression showed that correlations were found between the changes of RBP-4 and BMI,HOMA-IR,hs-CRP,TNF-α(β =0.284,0.506,0.274,0.230,P <0.01 ),and HOMA-IR was the most important limiting factor. Conclusions Mefformin can improve insulin sensitivity of the patients with IGT and MS, and depress the levels of RBP-4,hs-CRP and TNF- α. Meanwhile mefformin has anti-inflammatory effect.
5.Effects of δ-optoid receptor agonist on hemodynamics and oxygen metabolism in rats with sepsis
Wenming FENG ; Ying BAO ; Ming ZHU ; Xiaohong WEN ; Maoyun FEI ; Xiaolan ZHANG ; Xiaoying JIANG ; Yao WANG
Chinese Journal of Anesthesiology 2011;31(4):491-493
Objective To investigate the effects of δ-opioid receptor agonist DADLE (D-Ala2-D-Leu5-enkephalin) on the hemodynamics and oxygen metabolism in rats with sepsis. Methods Eighty healthy male SD rats were randomly divided into 4 groups ( n = 20 each) : sham operation group (group S), sepsis group (group SEP) ,DADLE, group and DADLE2, group. Sepsis was induced by cecum ligation and puncture (CLP) in SEP, DADLE,and DADLE2 groups. In DADLE1 and DADLE2 groups, 0.5 mg/ml DADLE 10 mg/kg was injected intraperitoneally (IP) 0.5 h before CLP and immediately after CLP respectively. Mean arterial pressure (MAP), left ventricular systolic pressure (LVSP) and ± dp/dtmax were recorded at 0, 2, 4 and 6 h after CLP (T1-4). Blood samples from left common carotid artery and right external jugular vein were collected at T4 for blood gas analysis. The cardiac index (CI), O2 delivery (DO2), O2 consumption (VO2) and O2 extraction rate (ERO2) were calculated.Results Compared with group S, MAP and LVSP were significantly increased at T2, while decreased at T3,4, and ± dp/dtmax was significantly increased in group SEP, MAP was significantly increased at T2, while decreased at T3,4, LVSP was significantly increased at T2,3, while decreased at T4 , and ± dp/dtmax was significantly increased in DADLE, and DADLE2 groups, and CI, DO2 and VO2 were significantly decreased and ERO2 was increased in SEP, DADLE, and DADLE2 groups (P<0.05). Compared with group SEP, MAP, LVSP and ± dp/dtmax at T3,4 and CI, DO2 and VO2 were significantly increased, while ERO2 was significantly decreased in DADLE1 and DADLE2 groups (P < 0.05). There was no significant difference in the parameters mentioned above between DADLE1 and DADLE2 groups ( P > 0.05). Conclusion δ-opioid receptor agonist DADLE can obviously improve the hemodynamics and oxygen metabolism in septic rats.
6.Study of soft capsule of compound oil of jujube, arborvitae, and gardenia on enhancing hypoxia tolerance and anti-fatigue in mice.
Ya-Hui CHEN ; Mei ZHU ; Bao-Li LI ; Zhao-Ying FU ; Feng GAO
Chinese Journal of Applied Physiology 2012;28(4):339-341
Animals
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Fatigue
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prevention & control
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Female
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Gardenia
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chemistry
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Hypoxia
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prevention & control
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Male
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Mice
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Mice, Inbred Strains
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Plant Extracts
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pharmacology
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Thuja
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chemistry
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Ziziphus
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chemistry
7.A randomized controlled trial: acclimatization training on the prevention of motion sickness in hot-humid environment.
Lei ZHANG ; Jun-Feng MAO ; Xiao-Nong WU ; Ying-Chun BAO
Chinese Journal of Applied Physiology 2014;30(3):279-284
OBJECTIVEIncidence and severity of motion sickness (MS) in hot-humid environment are extremely high. We tried to know the effect of two-stage training for reducing incidence and severity of ms.
METHODSSixty male subjects were divided into experimental group and control group randomly. Subjects in experimental group received: (2) adaptation training including sitting, walking and running in hot lab. After adaptation confirmation based on subjective feeling, rectal temperature, heart rate, blood Pressure, sweat rates and sweat salt concentration, we tested both groups by Coriolis acceleration revolving chair test and recorded Graybiel's score and grading of severity to evaluate whether adaptation training was useful; (2) Anti-dizzy training 3m later of deacclimatization contained revolving chair training for 10 times. Then we did the same test as mentioned above to evaluate effect of anti-dizzy training. RESULST: Graybiel' s score and grading of severity had no difference between two groups through acclimatization training (P > 0.05). While they had difference through anti-dizzy training (P < 0.01).
CONCLUSIONAdaptation training seems useless for reducing incidence and severity of MS in hot-humid environment, but anti-dizzy training is useful.
Acclimatization ; physiology ; Adolescent ; Hot Temperature ; Humans ; Male ; Motion Sickness ; physiopathology ; prevention & control ; Young Adult
8.Effect of lumbar nerve dorsal roots section on the rat bone structural changes of lower limb
Feng XU ; Zhong-Guo FU ; Dian-Ying ZHANG ; Ya-Ming CHU ; Bao-Guo JIANG ;
Chinese Journal of Microsurgery 2000;0(03):-
Objective To investigate the rat bone structural changes of lower limb following lumbar nerve dorsal roots section.Methods Forty-eight mature female Wistar rats were divided into posterior radi- cotomy(PR)and comtrol groups randomly.The bilateral femoral bone mineral density(BMD)and biome- chanics characteristics were analyzed 2,4 and 8 weeks after the radicotomy.The same operation except the radicotomy was done in the sham group.Results In PR group,2,4,and 8 weeks after the radicotomy,the BMD of femur was(0.221?0.008)g/cm~3,(0.213?0.015)g/cm~3 ,and(0.216?0.105)g/cm~3 ,respective- ly;while that was(0.223?0.005)g/cm~3,(0.218?0.014)g/cm~3 ,and(0.208?0.111)g/cm~3 in control group.No significant difference was observed between the two groups(P>0.05).In PR group,2,4,and 8 weeks after the operation,the mean maximum load in three-point bending test of femun midshaft was(93.64?8.76)N,(89.77?11.18)N and(93.21?8.74)N,respectively,and was lower than the values of the con- trol group at the same time point(95.94?6.29)N,(91.63?9.43)N,(95.57?8.64)N,However,there was no significant difference between the two groups(P>0.05).Accordingly,there was no significant difference in the energy absorption in femun midshaft between the two groups(P>0.05).Conclusion The selective rhizotomies of part lumbar never dorsal roots might not cause the loss of the femur BMD and the change of bio- mechanics property significantly in short period.
9.Clinical significance of myasthenia gravis-related autoantibodies
Yan-Feng LI ; Yong-Hong LI ; Yu-Zhou GUAN ; Jun-Bao ZHANG ; Li-Ying CUI ;
Chinese Journal of Neurology 2001;0(01):-
Objective To investigate the clinical significance of myasthenia gravis (MG) associated autoantibodies.Methods Titin,ryanodine receptor (RyR)and acetylcholine receptor (AChR) antibodies were examined in the sera of 74 myasthenia gravies patients by ELISA.Results AChR,Titin, RyR antibodies were detected in 77.0% (57/74),39.2% (29/74) and 32.4% (24/74) of the MG patients,respectively.For thymoma MG,AChR,Titin and RyR antibodies were detected in 76.2% (16/21),71.4% (15/21) and 52.4% (11/21) respectively.For late onset MG,Titin and RyR antibodies were detected in 77.3% (17/22) and 50.0% (11/22) respectively.With respect to the modified Osserman classification,the positve rate for Titin and RyR antibodies is much higher in more severe patients (X~2= 16.094,P=0.001;X~2=11.226,P=0.011).Titin antibodies was significantly related with RyR antibodies (r=0.380,P=0.001).Conclusions Titin and RyR antibodies show high sensitivity for thymoma MG,and the combination of serological and radiological testing can increase both sensitivity and specificity in diagnosis of thymoma MG.The levels of the two antibodies may serve as important prognosis markers in MG.The induction of the immune response against Titin and RyR and the possible pathogenic effects of the two antibodies will be further studied.
10.Problems and reflection on English teaching in department of gynecology and obstetrics for foreign students
Zhangye XU ; Feng ZHAO ; Ying BAO ; Wenmiao ZHANG ; Yunqin CHEN ; Yinping HUANG
Chinese Journal of Medical Education Research 2013;(8):761-763
Six years' English teaching in department of obstetrics and gynecology in Wenzhou Medical College were reviewed. Language and cultural differences are the main reasons hindering teaching quality. Rational use of a variety of teachers,preparing for lessons adequately,adoption of English image data,supplying and revising English teaching materials,using network auxiliary teaching and forming ef-fective education mode are conducive to improving English teaching quality in department of obstetrics and gynecology for foreign students.