ObjectiveTo investigate the corelation between fibrinogen in pleural effusion and pleural adhesion in tuberculosis exudative pleurisy.Methods234 cases of primary tuberculosis pleurisy were divided into 3 groups (A、B、C) according to their level of fibrinogen in pleural effusion from low to high. The incidence rates of pleural adhesion were assessed during the course of treatment and after treatment.ResultsThe incidence rate of pleural adhesion in the course of treatment were as those: group A 10.5%, group B 32.3%, group C 54.5%. After treatment, it was as those: group A 10.5%, group B 16.9%, group C 42.4%. Whenever, there was significant difference between group C and group A or B (P<0.05).ConclusionThe level of fibrinogen in pleural effusion may be associated with pleural adhesion, which hinder the recovery of patients.

The five-flavor theory of traditional Chinese medicines (TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper, by using the pharmacophore-based virtual screening technique, the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1 (TRPV1) by studying the TCM components' role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs. Therefore, the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components, and consistent with the inherited and additive characteristics.
Drugs, Chinese Herbal ; chemistry ; pharmacology ; Humans ; Smell ; TRPV Cation Channels ; antagonists & inhibitors ; metabolism ; Taste

Objective To investigate the prevalence and awareness status of hypertension in adult Gansu Gannan Tibetan population.Methods A total of 6948 adult ( aged 18 and over) Tibetan residents were selected by random cluster multistage method.Participants were divided into city,rural dwellers and rural nomads groups.Questionnaires were collected and blood pressure measured from all participants.Results Prevalence of hypertension in this district was 24.6％ ( 1708/6948),of which city,rural dwellers and nomadic areas were 25.3％ ( 848/3340 ),22.7％ ( 628/2765 ),27.5％ ( 232/843 ),respectively.Prevalence of hypertension was significantly higher in city than in rural dwellers group ( P ＜0.05 ),significantly higher in rural nomads group than in city and rural dwellers groups ( all P ＜ 0.05 ).Awareness,treatment and control rates of hypertension in city group were 35.7％ (303/848),25.1％ (213/848),6.9％ (59/848),respectively:in rural dwellers group were 28.3％ (178/628),19.3％ ( 121/628),4.7％ ( 30/628 ),respectively:in rural nomads group were 16.8％ ( 39/232 ),8.6％ ( 20/232 ),2.2％(5232),respectively.Rates of awareness,treatment and control were significantly lower in rural dwellers than in city group ( all P ＜ 0.01 ),and significantly lower in rural nomads group than in city and rural dwellers groups ( all P ＜ 0.01 ).Conclusions Prevalence of hypertension in Gansu Gannan Tibetan population aged 18 and over is high.Awareness,treatment and control rates of hypertension are low,especially in rural dwellers and rural nomads residents.

Objective To understand infection status,clinical and epidemiological features of respiratory tract infection(RTI) with human Bocavirus(HBoV) in children in Wuhan area.Methods A total of 968 hospitalized children with acute RTI between January and December 2016 were recruited in the study.Sputum specimens were collected by sterile negative pressure suction method.HBoV,respiratory syncytial virus,adenovirus,A/B-type influenza virus,and parainfluenza virus Ⅰ/Ⅱ/Ⅲ were detected,the prevalence and clinical features of HBoV infection were analyzed.Results Among 968 cases,75(7.75％) were positive for HBoV.The detection rates of HBoV in boys and girls were 5.68％ and 2.07％ respectively,there was no significant difference in the detection rate of HBoV between different genders(x2 =2.083,P =0.140);53 (70.67 ％) HBoV-positive children were＜ 1 year old,63(84.00％) were＜3 years old,there was significant difference in the detection rate among all age groups(x2 =4.60,P =0.043).The detection rates in spring,summer,autumn,and winter were 9.78％,5.29％,2.86％,and 5.20％ respectively;except September and October,HBoV was found positive in the other months,detection rate was highest in March (33.33％).17 cases were simple HBoV infection and 58 were mixed infection,the main clini cal diagnosis of HBoV was bronchopneumonia(n =26,34.67％).The main clinical features of HBoV cases were fever(81.33 ％),cough(77.33 ％),and wheezing (77.33 ％).Conclusion HBoV is one of the important pathogens causing RTI in hospitalized children in Wuhan area,HBoV infection can occur throughout the year,the peak season are spring and summer,there is no difference between different genders.The most common clinical diagnosis of HBoV in hospitalized children is bronchopneumonia,the main manifestations are fever,coughing,and wheezing.

Adolescent ; Adult ; Female ; Follow-Up Studies ; Humans ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; drug therapy ; Treatment Outcome ; Young Adult

OBJECTIVETo evaluate the bone-implant interfaces of two kinds of implants with different surfaces in different time in vivo.

METHODSCDIC and ITI-TPS solid-screw cylinder pure titanium implants were selected and implanted in the regions of posterior molars of rhesus monkeys. 1 month, 2 months, 3 months and 1 year after surgery, the bone-implant interfaces were evaluated respectively through oral examination, X-ray inspection, light microscope and scanning electron microscope (SEM) observation.

RESULTSNone of the implants was loose. Soft tissue around implants appeared no inflammation. There were no apparent transparent shadow around the implants interfaces in X-ray photos except little angle-shaped absorption was showed in neck region of CDIC implants of one-month. New bone was observed around implants of one-month through light microscope and SEM. More bone growing around ITI implants were seen than that around CDIC implants except the interfaces of one-year.

CONCLUSIONThe osseointegration of ITI implants are better than that of CDIC implants during three months after implanting without loading. The bone formation at the interfaces of ITI and CDIC implants has no significant difference after one year without loading.

Animals ; Dental Implants ; Macaca mulatta ; Molar ; Osseointegration ; Titanium

Fingerprint technology is the key technology in modern Chinese medicine research, while spectrum-effect relationship research is the advanced stage of fingerprint research. Spectrum-effect relationship research can reveal the relationship between fingerprint and pharmacological effect through multiple statistical analyses, which can be used in Chinese medicine research. Spectrum-effect relationship has been used in many areas of Chinese medicine research, such as effective basis of single and compound Chinese medicine research, component compatibility research, processing mechanism research, pharmacological effect forecast research, technology optimization research, and so on. This paper systematically reviewed the application of spectrum-effect relationship in Chinese medicine research, and indicated some problems in spectrum-effect relationship research. At last, the authors give an outlook of the future of spectrum-effect relationship research.
Animals ; Biomedical Research ; China ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; Humans ; Spectrum Analysis

·AIM:To describe the protocol and economic cost of the Day-care Unit cataract surgery procedure in northwest of China. ·METHODS: Patients who received phacoemulcification and intraocular lens implantation in both Day-care Unit and regular Unit were recruited from January 2016 to December 2016. The baseline data and average cost were recorded and analyzed. Furthermore, satisfaction questionnaire of patients were collected. ·RESULTS: Patients with Day-care Unit showed shorter registration duration, less cost including housing and nursing charge as well as higher rate of patient satisfaction. Meanwhile, Day-care Unit shorten the time the doctors and nurses spending on filling the medical charts. · CONCLUSION: Day - care Unit cataract surgery procedure could benefit both patients and medical staffs and is worthy to generalize.

OBJECTIVETo observe the clinical efficacy of electroacupuncture (EA) on mild cognitive impairment (MCI) for patients of Uygur and Han nationality and explore the national diversity among the patients with MCI.

METHODSTwenty-five cases were divided into Han nationality group (15 cases) and Uygur nationality group (10 cases) according to patient's nationality. In either group, EA was applied to Baihui (GV 20), Fengchi (GB 20), Xuanzhong (GB 39), Fuliu (KI 7), Sanyinjiao (SP 6) and Taixi (KI 3), once per day, 15 treatments made one session and there were 5 days at the interval among the sessions. Totally, 3 sessions of treatment were required. The proton magnetic resonance spectroscopy (1H-MRS) was used to observe the changes in the ratio of N-acetylaspartate and creatine (NAA/Cr) on the left hippocampus for the patients in two groups before and after treatment as well as the changes in the results of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) separately.

RESULTSNAA/Cr in Uygur nationality group was higher than that in Han nationality group before treatment (1.659 +/- 0.418 vs 1.137 +/- 0.190, P < 0.05). After treatment, MMSE and MoCA scores all increased apparently as compared with those before treatment in two groups (P < 0.05, P < 0.01), and NAA/Cr on the left hippocampus in either group was up-regulated as compared with that before treatment (both P < 0.01).

CONCLUSIONEA can improve the overall cognitive function for the patients with MCI. There is the national diversity in the partial brain metabolite level between Uygur patients and Han patients with MCI.

Aged ; Aged, 80 and over ; Aspartic Acid ; analogs & derivatives ; analysis ; China ; ethnology ; Cognition Disorders ; metabolism ; therapy ; Creatine ; analysis ; Electroacupuncture ; Female ; Hippocampus ; chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged

To study the impact of the enterovirus 71(EV71) on the nuclear transport mechanism,The pGFP-NLS vector with nuclear location signal(NLS) was constructed, RD cells transfected by the pGFP-NLS vector were inoculated with the EV71 or cotransfected by EV71-2A vector. The results showed that GFP protein with NLS was expressed in the cytoplasm due to the inhibition of nuclear transport. In order to further study the mechanism of the EV71 to prevent nuclear transport,Nup62 was detected by Western blotting after RD cells were infected with EV71 or transfected by EV71-2A vector. The results showed that decreased expression of Nup62 could be detected after infection with EV71 and transfection by EV71-2A vector. This study demonstrates that the cleavage of Nup62 by EV71 2A protease may be the mechanism of nuclear transport inhibition.
Active Transport, Cell Nucleus ; Cell Line, Tumor ; Cell Nucleus ; metabolism ; Enterovirus A, Human ; enzymology ; genetics ; metabolism ; Enterovirus Infections ; virology ; Gene Expression Regulation, Viral ; Genetic Vectors ; Green Fluorescent Proteins ; metabolism ; Humans ; Membrane Glycoproteins ; metabolism ; Nuclear Localization Signals ; metabolism ; Nuclear Pore Complex Proteins ; metabolism ; Peptide Hydrolases ; metabolism ; Recombinant Fusion Proteins ; metabolism ; Transfection