Objective To study epidemiological features of HIV infection after blood transfusion and the situation of transmission among members of family.Methods The persons infected with HIV through blood transfusion and their intrnfamilial transmission in some city were analyzed and testing methods of ELISA,Western-blot,RT-PCR and subtype analyzing were used.The whole surveillance data came from residents investigation around problem medical centres and HIV monitoring network around Hebei province.Results 173 people infected with HIV after blood transfusion in some city.including 89 cases found in hospital and 84 cases in CDC,accounted for 68.7%(173/252)of all of infected persons by blood transfusion in Hebei province.The rate of intrafamilial transmission,spousal transmission and mother-to-child transmission((MTCT)were 32.0% (49/153),17.0%(26/153)and 32.7%(32/98),respectively.Most of persons infected with HIV were youth among who the female were more than the male.Childbearing and women's ailments were the main cause of blood transfusion from 1990 to 1999,and traumatism surgery took second place.Infected persons by HIV blood,whose time to diagnostic were the year from 1999 to 2009,spread over Kangtai hospital and other hospital which accounted for 45.1%(78/173)and 42.2%(73/173),respectively.The genetype of all patients were B'subtype.Conclusion The medical centers at the grass-roolg level in some city resuhed in outbreak of infected persons bv HIV blood because of having no screening test antibody of HIV fur paid blood donors.