Objective To explore the role of HPV16 and p53 protein in the pathogenesis of tumors of nasal cavity and sinus of Chinese people. Methods The expression of HPV16 and p53 in 58 tumor samples of nasal cavity and sinus was detected by immunohistochemistry. Results There was no p53 expression in inverted pipillomas(IP). HPV16 infection rate in IP was 62.5%. The positive rate of p53 protein in the malignant tumors and IP with atypical hyperplasia was 56.0% and 44.4%, respectively, and HPV16 infection rate in the both tissues was 24.0% and 66.7%, respectively. The positive rate of p53 and HPV16 simultaneous expression in IP with atypical hyperplasia were 33.3%, which was higher than that in the malignant tumors and IP without atypical hyperplasia. Conclusion The high-risk HPV16 infection may be primary cause of IP. p53 gene mutation may be close relation with the pathogenesis of nasal cavity and sinus malignant tumors. HPV16 and p53 may have synergic effect in the malignant transformation of nasal cavity and sinus benign tumors.

0.05). Conclusion The p53 gene mutation has close relation with nasal malignant tumor , and may has no related to the pathogenesis of IP possible.

Objective:To realize the different disaster recovery of infectious disease net reporting system of Chinese Center for Disease Control and Prevention (China CDC) in the same city.Methods:We adopted B/S/DBMS three-tier architecture to deploy the infectious disease net reporting system in the disaster recovery center, realized data level disaster recovery through the remote replication technology, realized application level disaster recovery through technology of the data asynchronous replicating and transmitted disaster recovery data of the infectious disease net reporting system through asynchronous mode. Results: According to the existing resources, we established different disaster recovery center of the same city, realized the disaster recovery data backup of important information system in the same city, completed the security of software and hardware in information security level protection, and passed the level evaluation of Ministry of Public Security.Conclusion: The establishment of disaster recovery center in the off-sete of same city can make sure the security of the system and data, and ensure the continuity of work efficiency.

Objective To observe the clinical efficacy of acupoint application with Xiong Bi Tie in treating unstable angina pectoris. Method Sixty eligible subjects with unstable angina pectoris were randomized into a control group (treated with basic Western medication) and a treatment group (intervened by the basic Western medication plus acupoint application with Xiong Bi Tie), 30 cases in each group. The symptoms of unstable angina pectoris, syndromes and signs of traditional Chinese medicine (TCM), and cardiogram were recorded, and the clinical efficacies were also observed. Result In comparing the improvement of angina pectoris, the treatment group was better than the control group, with a statistical significance (P<0.05). From the perspective of TCM syndromes and signs, the efficacy of the treatment group was significantly better than that of the control group (P<0.05). Regarding the cardiogram, the total effective rate was 76.7% in the treatment group versus 50.0% in the control group, and the difference was statistically significant (P<0.05). Conclusion Acupoint application with Xiong Bi Tie can significantly improve the angina symptoms and cardiogram result of unstable angina pectoris (blood stagnation caused by qi deficiency syndrome), and it’s safe and easy-to-operate.

There is a high prevalence of gastric cancer in China,but most of the patients are diagnosed at advanced stages,when chemotherapy is regarded as an important component of the multimodal treatment.Chemotherapy has demonstrated advantages over best suppor-tive care in prolonging survival and improving quality of life.Over the past 40 years,the clinical responses of two or three-drug combination chemotherapy regimens have been accepted,and 5-fluorouracil,cisplatin and epirubicin have been most frequently used in gastric cancer.Recently,the therapeutic effects of advanced gastric cancer treated by new regimen consisted of docetaxel,irinotecan,oxaliplatin and capecitabine have been further enhanced.The molecular targeted agent,cetuximab and bevacizumab,combined with chemotherapy,would be more promising therapeutic regimens in the treatment of advanced gastric caner.

Humans ; Magnetic Resonance Imaging ; Neurosurgery ; trends

Fusion Proteins, bcr-abl ; genetics ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; complications ; genetics ; Male ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; etiology

Animals ; Bone Marrow Cells ; cytology ; Cell Differentiation ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Mesenchymal Stromal Cells ; cytology ; Myocytes, Cardiac ; cytology

BACKGROUND:Anterior cervical discectomy and intervertebral disc replacement have been extensively used in treatment of cervical degenerative disease. Its short-term therapeutic effects are encouraging, but it lacks of long-term and comprehensive evaluation.
OBJECTIVE:To observe the folow-up results of a group of cases of anterior cervical discectomy and Mobi-C intervertebral disc replacement for more than 5 years.
METHODS:A total of 25 cases of cervical spondylosis were treated in the 309 Hospital of Chinese PLA from January to September 2009. 19 of them were folowed up. Al patients received anterior cervical discectomy and Mobi-C intervertebral disc replacement. Twenty-three Mobi-C intervertebral disc prostheses were implanted. The range of motion was measured using lateral X-ray films during extension and flexion. Ectopic ossification was assessed by McAfee method. According to the cervical vertebra MRI images, the degeneration of adjacent segments was determined using Pearce classification. NDI score was used to evaluate the function of cervical spine. Pain improvement was evaluated using visual analogue scale score.
RESULTS AND CONCLUSION: A total of 19 patients were folowed up for 59-65 months, averagely 62 months. No significant difference in range of motion was detected before surgery and during final folow-up (P > 0.05). Ectopic ossification in two cases and the degeneration of adjacent segments in one case were found during final folow-up. No prosthesis loosening or displacement appeared. Visual analogue scale score and NDI score were significantly lower during final folow-up compared with that before surgery (P < 0.05). These results indicate that under the premise of reasonable choice of indications, the therapeutic effect of Mobi-C intervertebral disc replacement for degenerative cervical spondylosis was satisfactory in five-year folow-up. The range of motion was good, and the incidences of ectopic ossification and the degeneration of adjacent segments were low.

0.05). From clinical point of view,it is suggested that the weight can be advantageous to forecasting Cr of children.