This study involved 72 pregnancies admitted to the Obsteo-gynecological Department of Hue Central Hospital between September/1995 to January/1998. The results suggested that misoprotol is effective for termination of pregnancy. Successful rate of this method is higher than that of oxytocin method in all subjects. Mean dose is 3.2+/-1.3 tables (Cytotect table of 200mg). Complications are infrequent.
Stillbirth ; Pregnancy

Background: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. Methods: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed. Results: BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression. Conclusions In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.