Multiple myeloma (MM) is malignant plasma cell clonal disease.Autologous stem cell transplantation (ASCT) strengthen the advantages of the high-dose chemotherapy in treatment of MM,which achieves long-term survival in some patients.Even in the era of targeted novel agents,ASCT can still obviously increase the response rate of treatment.To improve the therapeutic efficacy,targeted novel agents were administrated before and after ASCT.However,targeted novel agents still cannot replace ASCT therapy in the treatment of MM.The direction of future research is to find more reasonable,effective and low toxic treatment.

Objective To evaluate the efficacy and safety of Dextromethorphan Hydrochloride, Chlorphenamine Malente, and Ammonium Chloride Syrup on eliminating or relieving the symptoms of acute upper respiratory infections in children, by comparing with Guaifenesin, Dextromethorphan Hydrobromide, Methylephedrine Hydrochloride, and Chlorphenamine Maleate Syrup. Methods Random, blind and parallel control method was adopted. A total of 253 pediatric patients were recruited in 11 clinical research centers; 127 patients were assigned in experimental group and finally 118 patients were included in the program set analysis (PPS); 126 patients were assigned into control group and finally 116 patients were included in PPS. The experimental group took Dextromethorphan Hydrochloride, Chlorphenamine Malente, and Ammonium Chloride Syrup and control group took Guaifenesin, Dextromethorphan Hydrobromide, Methylephedrine Hydrochloride, and Chlorphenamine Maleate Syrup. All of the patients took as prescribed at least for 3 days but not more than 7 days. Results There was no significant differences in age, sex, and acute upper respiratory tract infection scores between the two groups (P?>?0.05). PPS showed the median time of symptom relief of acute upper respiratory tract infection in experimental group was 51.0 h (95%CI: 43.0-62.0 h) and 56.0 h (95%CI: 48.0-64.0 h) in control group. There was no difference between two groups (P?>?0.05). After calibration of center and baseline effects, the experimental group was not worse than the control group. There was no difference in the score of acute upper respiratory tract infection between two groups (F=0.14, P=0.710). The individual symptoms disappear rate of acute upper respiratory tract infection and the compliance between two groups were similar (P all?>?0.05). Both groups had 7 cases of adverse events, and one case of adverse drug reactions each. Thus, the adverse reaction rates in two groups were 0.8% each. Conclusions Dextromethorphan Hydrochloride, Chlorphenamine Malente, and Ammonium Chloride Syrup can effectively relieve symptoms rapidly in the treatment of children with acute upper respiratory tract infection, and its efficacy and safety were non worse than traditional Guaifenesin, Dextromethorphan Hydrobromide, Methylephedrine Hydrochloride, and Chlorphenamine Maleate Syrup.

Object detection systems are widely used in many fields. To speed up object detection, a rapid method based on color feature is presented in this paper. Artificial neural network is used for color classification. A series of original objects are gained through searching the most outstanding feature of the marker based on multi-resolution. A set of features obtained from these original objects in the original image, and artificial neural network are used for object classification. Experimental results prove the effectiveness of this method.

Lumbar disc herniation is a common male disease. In the past, More academic attention was directed to its relationship with lumbago and leg pain than to its association with andrological diseases. Studies show that central lumber intervertebral disc herniation may cause cauda equina injury and result in premature ejaculation, erectile dysfunction, chronic pelvic pain syndrome, priapism, and emission. This article presents an overview on the correlation between central lumbar intervertebral disc herniation and andrological diseases, focusing on the aspects of etiology, pathology, and clinical progress, hoping to invite more attention from andrological and osteological clinicians.
Chronic Pain ; etiology ; Erectile Dysfunction ; etiology ; Humans ; Intervertebral Disc Displacement ; complications ; Lumbar Vertebrae ; Male ; Pelvic Pain ; etiology ; Polyradiculopathy ; etiology ; Premature Ejaculation ; etiology ; Priapism ; etiology

Humans ; Medicine, Chinese Traditional ; Qi ; Thymoma ; surgery ; therapy

Objective: To explore whether short hairpin RNA (shRNA) targeting Bcl-2 can enhance the inhibitory effect of methotrexate (MTX) on growth of subcutaneously-transplanted human lymphoma in nude mice. Methods: Recombinant shRNA expression vector targeting the coding region of Bcl-2 mRNA was constructed and preserved in our lab. Human lymphoma Raji cells were injected subcutaneously into 45 nude mice to establish lymphoma models. The polyethylenimine (PEI)/shRNA complex and (or) MTX were injected into tumors. The influence of Bcl-2 shRNA and (or) MTX on tumor growth was observed. The animals were sacrificed 21 days after administration of drugs and the tumors were removed and weighed; the tumor inhibitory rate was calculated. H-E staining was used to observe the pathological morphology of the tumor. The expression of Bcl-2 mRNA in the tumor tissues was examined by RT-PCR. Results: The tumor growth was significantly slower in Bcl-2 shRNA/MTX group than in Bcl-2 shRNA or MTX alone groups (P<0.05). The tumor weight of mice in Bcl-2 shRNA plus MTX group was significantly lower than those in negative shRNA and blank plasmid group (P<0.05). The inhibition rate of tumor growth in Bcl-2 shRNA/MTX was significantly higher than those in the Bcl-2 shRNA or MTX alone groups (P< 0.05). H-E staining showed obvious apoptosis and necrosis in Bcl-2 shRNA group and MTX group. RT-PCR result showed that the expression of Bcl-2 mRNA in tumor cell suspension was significantly decreased in Bcl-2 shRNA group (P<0.05), and kept unchanged in the control group. Conclusion: The shRNA targeting Bcl-2 can enhance the inhibitory effect of MTX on the growth of subcutaneously transplanted human lymphoma in nude mice.

Objective The purpose of this study was to investigate the effects of propofol on the platelet function.Methods Thirty ASA Ⅰ-Ⅱ patients undergoing elective minor surgery were allocated into two groups: propofol group (n=20) and control group (n=10). The mean age of the patients was (37?8)yr. Patients who had blood disease or had been exposed to any medication with known platelet effects were excluded. The patients were premedicated with phenobarbital sodium 2mg?kg -1 and atropine 0.01 mg?kg -1. In propofol group anesthesia was induced with propofol 2 mg?kg -1, fentanyl 4?g?kg -1 and vecuronium 0.1 mg?kg -1 and maintained with 0.8%-1.2% isoflurane inhalation supplemented with fentanyl and vecuronium. The duration of operation averaged (85?15)min. Blood samples were taken from peripheral vein before induction of anesthesia, 5 and 30 min after induction and 1h after termination of propofol infusion for the assessment of CD62P,CD63 and CD41/CD61 on the platelet membrane surface by flow cytometry. Platelet count, bleeding time and ACT were also determined at the same time.Results Following the administration of propofol the expressions of CD62P and CD63 on the platelet membrane surface were significantly decreased, whereas the expression of CD41/CD61, platelet count, bleeding time and ACT did not change significantly.Conclusions Propofol inhibits the expression of platelet membrane glycoproteins CD62P and CD63 and may contribute to the impairment of platelet function.

Adult ; Antibiotics, Antineoplastic ; therapeutic use ; Benzamides ; Blast Crisis ; drug therapy ; Drug Resistance, Neoplasm ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; drug therapy ; Male ; Piperazines ; pharmacology ; Pyrimidines ; pharmacology ; Sirolimus ; therapeutic use

Object Polysaccharide constituents in the seed of Cuscuta chinensis Lam were investigated Methods Individual constituent was isolated and purified by DEAE cellulose and gel filtration chromatography, and its structural features were further studied by physicochemical constants, and spectral analysis Results Two polysaccharides, named H6 and H8, were obtained from alkalescent or boiling water extract fractions, respectively The molecular mass of H6 was 3 14?10 5 and that of H8 was more than 1 0?10 6 Both structures were found to be complex neutral heteropolysaccharides composed of Ara, Rha, Gal and Xyl Conclusion These polysaccharides were obtained from this plant for the first time

Objective To explore the effect of low-dose dexmedetomidine on hemodynamics of general anesthesia in hypertensive patients.Methods A total of 92 patients with hypertension were enrolled from May 2015 to February 2016 in People's Hospital of Fenghua District, Ningbo City were randomly divided into observation group and control group,with 46 cases in each group.All patients were treated with static and general anesthesia, the observation group before induction of general anesthesia 10 min received continuous intravenous micro-pump injection of dexmedetomidine 0.3 μg/kg(diluted with saline 20 mL);The control group received intravenous micro-pump injection physiology saline 20 mL.The mean arterial pressure(MAP)and heart rate(HR)before and after treatment, and the operation time, recovery time, extubation time, RSS sedation score and adverse reaction occurred were compared between the two groups.Results There was no significant difference in MAP and HR between the two groups before treatment.After treatment, the serum MAP of the two groups was increased, but the MAP in the observation group was(109.2±10.2)mmHg significantly lower than that in the control group(116.1±11.3)mm Hg,and HR in the observation group was(71.9±3.1)mmHg significantly lower than that in the control group(92.1±2.8)mmHg.The difference between the two groups was statistically significant(P<0.05).There was no statistically significant difference between the two groups in terms of operation time, recovery time and extubation time.The RSS sedation scores of the observation group before extubation(T1), extubation(T2)and extubation 1 min(T3)were higher than those of the control group.At T1, the RSS sedation score in the observation group was(2.3±0.4)points higher than that of the control group(1.8±0.3)points, At T2, the RSS sedation score was(2.9±0.4)points higher than that of the control group(2.1±0.3),At T3, the RSS sedation score was(2.5±0.3)points higher than that of the control group(1.9±0.3).The difference between the 2 groups was statistically significant(P<0.05).There was no significant difference between the two groups in adverse reactions.Conclusion Small doses of dexmedetomidine can reduce the patient's pumping, extubation and other stress response, providing the appropriate sedative effect, help to stabilize the patient's hemodynamic parameters, to ensure the effect of anesthesia and surgery to improve surgical safety.