Multiple myeloma (MM) is a clonal plasma cell malignancy, a low proliferative and low apoptotic activity molecular cloning of a disease, which indicates that apoptosis inhibition may play an important role in the pathogenesis of MM. Therefore, the study of MM pathogenesis-related promoting apoptosis genes/proteins and inhibiting of apoptosis genes/proteins, as well as the correlation between them provides a new strategy for molecular targeted therapy.

The onset of irreversibility of cardiovascular diseases caused by obesity has showed a rising trend,the underlying cause of the disease is the endothelial damage.Injury caused by obesity through four aspects:systolic and diastolic imbalance,anticoagulant and procoagulant imbalance,growth factors and growth factor imbalances and endothelial progenitor cell changes in endothelial damage.This paper reviews the reason and the mechanism of the endothelial damage through the change of the endothelial factors and progenitor cells.

WGA-HRP was iontophoretically delivered into the habenular nuclei in 40 rats to observe the distribution of the retrograde labeled cells; and into the entopeduncular nucleus(EPN), lateral preoptic area(LPO), medial preoptic area(MPO), nucleus septalis fimbriatis(SF), nucleus triangularis septi(TS), nucleus tractus diagonalis (Broca)(DBN)and lateral hypothalamic area(LHA) in 12 rats to observe the distribution of the orthograde labeled fibers in the habenular nuclei. It was found that the afferents of various parts of the habenular nuclei were different.The lateral habenular nucleus mainly recieves the afferents from the EPN, LPO and LHA, and the medial habenular nucleus from the SF, TS and LHA. Furthermore, the lateral habenular nucleus can be divided into medial and lateral parts, the medial habenular nucleus can be divided into medial and lateral parts as well, their afferent connections are also different.

WGA-HRP was iontophoretically delivered into various parts of the habenular nuclei (the lateral segment of the lateral habenular nucleus LHb-L, the medial segment of the lateral habenular nucleus LHb-M, and the medial habenular nucleus MHb) in 40 rats to study the route and distribution of the anterograde labeled fibers and terminals in the brain. The efferent projections of the habenular nuclei follow three routes, the rostral, contralateral and caudal pathways. Along the rostral pathway fibers leave the lateral habenular nucleus, follow the stria medullaris thalami rostrally, and distribute to the thalamic dorsomedial nucleus, paratenial nucleus and lateral preoptic area. Fibers from the contralateral pathway distribute to the opposite lateral habenular nucleus by way of the commissura habenularum Fibers in the caudal pathway originate mainly from the MHb and LHb-M, and distribute to the interpeduncular nucleus with a dorsoventral topographic localization. In addition some of the caudal efferent fibers run caudally and terminate in the raphe nuclei and reticular formation etc.

The theme of this article lies in how to preserve the anus or restore the anal function in the treatment of middle or lower rectal cancer in order to avoid abdominal artificial anus,on the basis of not violating the principles of radical resection.From August 1995 to October 2004,86 cases of rectal cancer were operated with radical resection,48 of which preserved anus.Based on close observation of the patients,postoperative anal function seems the best in those with Dixon's anterior approach.if transplantation of the gracilis muscle is successful,satisfactory function restoration is always possible.Many scholars ever reformed Dixon's resection with lots of operative procedures,such as Bacon's resection.Because stapler can join rectal and anal together at any location,Bacon's resection is seldom adopted in clinical practice.The indications for anus preserving operation are as follows:①early or middle stage disease with localized lesion not invading beyond the muscle layer of the bowel;②no metastatic regional lymph adenopathy and;③adenocarcinoma at high or moderate degree of differentiation.It is suggested that different types of operative procedures are adopted according to the location of the lesion.

A pressure swing adsorption nitrogen generating device for producing nitro- gen enriched gas from compressed air was discussed.Utilizing the feature of the molecular sieve carbon with the property of selective adsorbing oxygen and ni trogen,the device enriches the product nitrogen at gas phase,and uses the gas lower in concentration than the product nitrogen for flushing residual gas,it help molecular sieve carbon with desorption.

Objective To compare of pathogenic bacteria characteristics between praecox and tardus ventilator-associated pneumonia (VAP) in the elderly with critical illness,and to provide the guildline and evidence of clinical prevention and treatment. Methods The clinical data of 276 VAP patients aged (69.3 ± 5.3) years in our hospital were retrospectively analyzed.There were 97cases (35.14％) with praecox VAP,179 cases (64.86％) with tardus VAP.Vitek 32 system was applied to identify pathogenic bacteria. Results In patients with praecox VAP,105 pathogenic bacteria were isolated,among which 72 cases(68.57％) suffered from G- bacterium,21 cases (20.00％) from G+ and 12 (11.43％) from fungus. The most widely distributed pathogens were hemophilus (22.86％),streptococcus pneumoniae(14.28％ ) and staphylococcus aureus(14.28％).In the patients with tardive VAP,186 pathogenic bacteria were isolated including 117(62.90％) G- bacterium,54 (29.04％)G+ bacterium and 15 (8.06％) fungus; the most widely distributed pathogens were staphylococcus aureus (24.19％), pseudomonas aeruginosa (22.58％) and klebsiella pneumoniae (14.52％).The death rate of tardus VAP(24.58％) was significantly higher than of praecox VAP (10.31％ ) (x2 =8.14,P＜0.05).The durations in ICU and mechanical ventilation were much longer in tardus VAP[(10.3±4.2)d and (7.8±2.7)d] than in praecox VAP[(7.8±3.1) d and (3.7±1.1)d] (t=5.15,14.32,P＜0.05). Conclusions There is differences in pathogenic bacteria distribution between praecox and tardus VAP,and the prognosis of tardus VAP may be worse.

Medical imaging is a medical discipline with strong practicality.Picture archiving and transmission system ( PACS ) provides a convenient and effective method for the clinical teaching of diagnostic imaging,especially for the students from the University of Traditional Chinese Medicine.Applying PACS is more convenient to gain and manage typical images,more effective to study and teach individually and easier to probe novel method for medical imaging.

Objective To survey health management cognition of residents in Shanghai city communities,and to analyze the causes,and to put forward related suggestions.Methods In October of 2013,this study was conducted in communities of Shanghai central district (Xuhui District),urban border area (Minhang District),and suburban area (Jinshan District); 800 residents from each health management cognition outpatient clinic (400 people from each of hospitals and community health service center),totally 2 400 residents were studied and investigated in the communities of Shanghai city,and 2 082 questionnaire were received (the questionnaire recovery rate was 86.75％).We used stratified random cluster sampling method,and self-designed investigation form,and did pre-experiment.The Survey included:Whether family doctors need to carry out the evaluation work about risk factors,to implement health management for school students,to implement health management for people over 60 years old,to implement the elderly health management for pension agencies,to implement special crowd health management for special people;conduct questionnaire of demand level for different population groups (type,age,gender,marital status,retirement,occupation,level of education and medical insurance form).Results The research results found that,when asked about the family doctor whether to carry out risk assessment,family doctor whether to implement special health management,whether family doctors need to teach health management to students, whether family doctor should undertake the health management work for the people over the age of 60,whether family doctors should implement special health management,whether a person thinks that it is indifference (9.3％,7.4％,3.8％,6.2％ and 5.7％) and unnecessary (3.6％,4.4％,2.5％,4.2％ and 3.9％)in the minority,the majority of people believe that they need (51.1％,52.9％,57.2％,55.6％ and 55.3％),then the general (24.5％,18.9％,12.4％,18.0％ and 16.5％) and very necessary (11.5％,16.4％,24.1％,16.0％ and 18.6％).Among them,the occupation,whether retired or not,level of education,medical insurance form and different age groups had different cognition and demand level for health management work.Conclusion To Strengthen the health management training,to take specific health management services according to different groups of people and to improve community health management services are very important.

On the basis of a retrospective summary of the policies for foreign-invested hospitals in China,this paper analyzed the main issues facing wholly foreign-owned hospitals and suggested a basket of strategies to promote the development of such hospitals in China (Shanghai)Pilot Free Trade Zone.