1.Antimicrobial indole alkaloids from Tabernaemontana corymbosa.
Kun FAN ; Lanchun ZHANG ; Bangyin TAN ; Guy S S NJATENG ; Malong QIN ; Ruirong GUO ; Xiaojuan HUANG ; Cai-Feng DING ; Weimin GAO ; Rongping ZHANG ; Haofei YU
Chinese Journal of Natural Medicines (English Ed.) 2023;21(2):146-153
Four unreported monoterpene indole alkaloids, tabernaecorymines B-E (1-4), together with twenty-one known indole alkaloids (5-25) were obtained from the stem bark of Tabernaemontana corymbosa. Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, DP4+ probability analyses and Mo2(OAc)4-induced electronic circular dichroism experiment. The antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus,Bacillus subtilis, Streptococcus dysgalactiae and Candida albicans.
Tabernaemontana
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Anti-Infective Agents
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Antifungal Agents
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Anti-Bacterial Agents
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Indole Alkaloids
Result Analysis
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