2.Characteristics of occurrence of pneumoconiosis in Jiangsu Province between 2006 and 2007.
Bang-mei DING ; Peng ZHOU ; Li-zhuang XIE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(1):36-37
Adult
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Aged
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China
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epidemiology
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Female
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Humans
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Male
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Middle Aged
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Pneumoconiosis
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epidemiology
4.Practice and experience of a case applying for diagnosis and identification of occupational chronic benzene poisoning.
Bang-mei DING ; Heng-dong ZHANG ; Bin YU ; Yuan ZHAO ; Wen-jing ZHU ; Bao-li ZHU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(11):875-875
Adult
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Benzene
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poisoning
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Chronic Disease
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Female
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Humans
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Occupational Diseases
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diagnosis
5.Health condition of workers exposed to silica dust in 6 quartz processing industry enterprises in Lianyungang city.
Ya-ping HUO ; Ri-hui ZHOU ; Bo SUN ; Bao-li ZHU ; Ru-yan YNAG ; Fang-wen GONG ; Li-zhuang XIE ; Bang-mei DING
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(11):849-850
Adolescent
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Adult
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Dust
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analysis
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Female
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Health Status
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Humans
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Industry
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Male
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Middle Aged
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Occupational Exposure
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analysis
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Quartz
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Young Adult
6.The level of welding fume and the healthy status of dust workers in electric welder's pneumoconiosis surveillance sentinel of one city.
Chun-hua LU ; Bao-li ZHU ; Ji-hong YANG ; Bang-mei DING ; Ze-yun YANG ; Ping ZHOU ; Shi-wei YIN ; Li-zhuang XIE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(11):847-848
7.Changes in activities of SOD and GSH-Px in induced sputum and their significance among silicosis patients.
Rong-ming MIAO ; Bang-mei DING ; Xue-tao ZHANG ; Zhong-hua FANG ; Rui ZHAO ; Ying-yi ZHANG ; Dao-kun ZHAO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(12):924-926
OBJECTIVETo observe the changes in activities of superoxide dismutase (SOD) and glutathione peroxide (GSH-Px) in the induced sputum of silicosis patients, and to investigate the roles of SOD and GSH-Px in the development and progression of silicosis and the significance of measuring activities of SOD and GSH-Px in induced sputum among silicosis patients.
METHODSFifty hotel attendants were chosen as control group, 50 workers with more than one year of silica dust exposure as dust exposure group, 32 silica dust-exposed workers as observation subject group, and 52 silicosis patients as silicosis group. The activities of SOD and GSH-Px in their induced sputum were measured by enzyme-linked immunosorbent assay.
RESULTSCompared with the control group, the observation subject group and silicosis group had significantly decreased SOD activity (68.16 ± 30.17 and 66.38 ± 47.32 U/ml vs 75.81 ± 11.92 U/ml, P < 0.05); compared with the dust exposure group, the silicosis group had significantly decreased SOD activity (66.38 ± 47.32 U/ml vs 70.12 ± 14.31 U/ml, P < 0.05). Compared with the control group and dust exposure group, the observation subject group and silicosis group had significantly increased GSH-Px activity (268.21 ± 15.45 and 279.34 ± 29.26 U/ml vs 224.22 ± 12.64 and 236.41 ± 14.54 U/ml, P < 0.05 or P < 0.01).
CONCLUSIONThe SOD activity in dust exposure group and silicosis group decreased, but there were no significant differences between patients with different stages of silicosis. The GSH-Px activity in dust exposure group and silicosis group was significantly higher than that in control group, and there were significant differences between patients with different stages of silicosis. These suggest that the imbalance of oxidative/antioxidant systems is associated with the development and progression of silicosis.
Adult ; Case-Control Studies ; Glutathione Peroxidase ; metabolism ; Humans ; Middle Aged ; Silicosis ; enzymology ; Sputum ; enzymology ; Superoxide Dismutase ; metabolism
8.Prevalence on overweight and obesity in Han, Uygur and Hazakh in adults from Xinjiang
Cheng LIU ; Xiang MA ; Yi-Tong MA ; Fen LIU ; Yi-Ning YANG ; Ding HUANG ; Xiao-Mei LI ; Ying HUANG ; You CHEN ; Bang-Dang CHEN ; Xiang XIE
Chinese Journal of Epidemiology 2010;31(10):1139-1143
Objective To investigate the prevalence and distributing feature of overweight and obesity in Han, Uygur and Hazakh population in adults from Xinjiang. Methods Four-stage selected random samples with maternal age at 35 or over were used to analyze the prevalence and distributing feature of self-reported congestive heart failure in different nationalities, age, sex. The sampled adult population were collected from 6 localities(Urumqi, Kelamayi, Fukang, the Turfan Basin locality, Hetian locality, Yili Hazakh autonomous prefecture), 23 municipalities and 7 locality and 5 autonomous counties in Xinjiang. Results 16 460 people were surveyed. The prevalence rates of overweight and obesity were 36.1% and 26.9% in Han, Uygur and Hazakh population in Xinjiang,respectively from February, 2007. The prevalence rates of overweight and obesity were 41.4% and18.4% in Han population, 34.9% and 28.9% in Uygur population, but 32.8% and 40.1% in Hazakh population. The prevalence rate of overweight and obesity was higher in males(x2= 135.00, P<0.05).The prevalence rates of overweight and obesity were different between different ethnic groups(x2=338.232, P<0.05). The prevalence of overweight was highest in Han population, with the highest seen in Hazakh population. The prevalence rates of overweight and obesity were increasing with age (x2=246.80,P<0.05). The overweight rate in 45-54 year olds and the obesity rate in 55-64 year olds reached their peak values. Results from logistic regression model analyses indicated that the prevalence of overweight and obesity in Xinjiang were statistically associated with age, educational level, jobs, smoking and alcohol consumption. Conclusion The prevalence rates of overweight and obesity were much higher in the population of Xinjiang but different among ethnicities. The prevalence of overweight was the highest in Han male population and the rate of obesity in Hazakh male population was the highest.
9.Expression of Btk and NFκB in acute myeloid leukemia cells and its significance.
Shan-Dong TAO ; Yuan DENG ; Zheng-Mei HE ; Yue CHEN ; Zhi-Kui DENG ; Yuan-Yuan LI ; Jia-Bin ZHU ; Bang-He DING ; Liang YU
Journal of Experimental Hematology 2013;21(1):25-28
This study was purposed to investigate the expression of Btk and NFκB in acute myeloid leukemia (AML) cells and its significance. Bone marrow mononuclear cell specimens were taken from 14 AML patients who were in new diagnosis and complete remission respectively, the expressions of Btk and NFκB at mRNA and protein levels were detected by RT-PCR and Western blot, respectively. The results showed that Btk and NFκB expressed in all the samples at RNA and protein levels. At protein level, Btk and NFκB expressions were higher in the cells from newly diagnosed AML patients than that in the cells from patients in complete remission stage (P < 0.05). It is concluded that Btk and NFκB may play an important role in the development and progression of AML, they may be used as potential therapeutic targets of AML and used in predicting the prognosis.
Adolescent
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Adult
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Aged
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Child
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Child, Preschool
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Female
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Humans
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Leukemia, Myeloid, Acute
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genetics
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pathology
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Male
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Middle Aged
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NF-kappa B
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genetics
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Prognosis
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Protein-Tyrosine Kinases
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genetics
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RNA, Messenger
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genetics
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Young Adult
10.Association between serum amyloid protein A1 polymorphisms and carotid intima media thickness in Han Chinese.
Xiang XIE ; Yi-tong MA ; Yi-ning YANG ; Zhen-yan FU ; Xiao-mei LI ; Xiang MA ; Ding HUANG ; Fen LIU ; Bang-dang CHEN ; Yang XIANG ; Ying HUANG
Chinese Journal of Cardiology 2011;39(4):320-324
OBJECTIVETo explore the association between genetic polymorphism of serum amyloid protein A1 (SAA1) with carotid intima media thickness in a healthy Han Chinese population of Xinjiang.
METHODSA total of 449 healthy Han Chinese participating the cardiovascular risk survey between June 2007 and September 2009 were included, the genotypes of the SAA1 were detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The mean IMT of the right and left common carotid arteries were measured by B-mode ultrasonography.
RESULTS(1) There was strong linkage disequilibrium between rs12218 and rs2229338 (D' = 0.89). (2) The carotid common IMT (CC-IMT) and the carotid bulb IMT (CB-IMT) were similar between the AA genotype (wild genotype) and the GGFAG genotype (mutational genotype) in rs2229338 of SAA1 gene. (3) CC-IMT [(0.081 ± 0.071) cm vs (0.068 ± 0.019) cm, P = 0.01] was significantly thicker in CC + CT genotype (mutational genotype) group than in TT genotype (wild genotype) of rs12218 group and the difference remains significant after adjustment for age, gender, blood pressure, waist circumference, creatinine and high density lipoprotein cholesterol. CB-IMT [(0.085 ± 0.038) cm vs. (0.081 ± 0.052) cm, P = 0.36] was similar between CC + CT genotype and TT genotype of rs12218 groups.
CONCLUSIONOur results suggested that the genetic polymorphism of SAA1 might be linked with IMT and rs12218 mutation could serve as a promoting factor for IMT in Han Chinese people.
Aged ; Asian Continental Ancestry Group ; genetics ; Carotid Intima-Media Thickness ; Female ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Serum Amyloid A Protein ; genetics