1.Reduction of FXIII during myelosuppression in acute leukemia after chemotherapy and adverse relation with bleeding events.
Yan Zhi WANG ; Bang Yun TAN ; Lin LI ; Zi Jian LI
Chinese Journal of Hematology 2020;41(1):59-63
Objective: To explore the relationship between plasma coagulation factor XIII (FXIII) and bleeding events. Methods: A total of 55 cases of acute leukemia (AL) at the myelosuppression phase after chemotherapy hospitalized in our hospital from August 2017 to March 2018 were enrolled, with 35 normal controls. The concentration of plasma coagulation factor XIII (FXIII) was detected by ELISA to determine the relationship between the plasma FXIII levels in AL patients at the myelosuppression phase after chemotherapy with bleeding events. Results: The level of FXIII in AL patients at the myelosuppression phase after chemotherapy was significantly lower than that in controls (P<0.001) . The level of FXIII was inversely related with the bleeding severity (the Spearman correlation coefficient -0.761) . Given the diagnosis cut-off point of FXIII concentration as 103.9 μg/L, the sensitivity of diagnosing bleeding in AL patients at the myelosuppression phase after chemotherapy was 0.939, and the specificity 0.909. Conclusion: AL patients at the myelosuppression phase after chemotherapy had low level of plasma FXIII, and patients with lower plasma FXIII associated with higher incidence and severity of bleeding. FXIII level was an independent influencing factor of bleeding in AL patients at the myelosuppression phase after chemotherapy.
Acute Disease
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Blood Coagulation Tests
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Factor XIII
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Factor XIII Deficiency
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Hemorrhage
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Humans
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Leukemia
2.PROSI Mutation With Clinical Heterogeneity in Protein S Deficiency:Report of One Case.
Xin-Yu WEI ; Juan WANG ; Bang-Yun TAN ; Zi-Jian LI
Acta Academiae Medicinae Sinicae 2023;45(5):863-866
Reduced protein S activity is one of the high-risk factors for venous thromboembolism.Hereditary protein S deficiency is an autosomal dominant disorder caused by mutations in the PROS1 gene.We reported a female patient with a mutation of c.292 G>T in exon 3 of the PROS1 gene,which was identified by sequencing.The genealogical analysis revealed that the mutation probably originated from the patient's mother.After searching against the PROS1 gene mutation database and the relevant literature,we confirmed that this mutation was reported for the first time internationally.
Humans
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Female
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Protein S/genetics*
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Protein S Deficiency/genetics*
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Pedigree
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Mutation