No abstract available.
Herpes Simplex*

Compared with the antipsoriatic retinoid etretinate, the new aromatic retinoid ar, itretin represents an important, advance due to its rapid eliminatian kinetics. Therefore acitretin treatment may represent an important alternative to etretinate in females of childbearing potential. From recent clinical studies it appears that acitretin and etretinate have similar therapeutic effectiveness in severe poriasis including generalized putular psoriasis and psoriatic erythroderma. We preset a case of generalized pustular psoriasis in a 18 year old female who was treated successfully with aritretin. She had generalized pustular eruptions on erythematous base associated with high fever and chills. With the administration of acitretin at a dose of 30mg/day, marked improvement was achieved.
Acitretin* ; Adolescent ; Chills ; Dermatitis, Exfoliative ; Etretinate ; Female ; Fever ; Humans ; Kinetics ; Psoriasis*

In the survey of l1,005 subjects in l3 villages of Che Ju lsland, 1,450 persons were egg-positive by repeated sputum examinations. The response rate to intradermal test ranged 50-80 per cent of the population and to sputum examination for skin positive 60-70 per cent in the first survey done in l964. 93 per cent of all egg-positive was treated with 40 mg/kg body weight of bithionol on alternate days for 10-15 doses in l965. Follow-up studies were carried out in one year, three-year, five-year, and eight year after the mass treatment. The one year follow-up study covered 86.5 per cent of all treated cases in all villages but only a part of the population of a few villages in further follow-up studies. In this paper only the result obtained from the age group of 7-18 years, the common population studied in every follow-up for the purpose of comparison, is presented. Intermediate hosts of P. westermani were examined at the same time. In one year follow-up it was found that 91 per cent of egg-positive treated became negative. Three parameters, skin reaction, sputum examination, and infection status of intermediate hosts by area and year were used for comparison. Skin positive rate showed gradual decrease with more marked drop in Kang Chung where more thorough survey and mass treatment (about 43 per cent of all infected persons estimated among whole population) were carried out than other areas (only 20-30 per cent). The proportion of intermediate skin reation (60-100 mm(3) wheal size) increased markedly indicating decreased dose of infection which corresponds to the dropped infection rate and average number of metacercaria in crabs. Egg-positive rate in sputum examination done for skin positive reactors also presented similar pattern to skin reaction although it should be taken account that the result of 1964 was from repeated sputum examinations but that of other years from a single examination. Increased proportion of intermediate skin reaction which has much lower egg-positive rate probably played major role in decreased egg-positive rate. The infection rate of snail started to drop about one year earlier than crab; crab infection rate and intensity started to drop about four year after the mass treatment. The duration needed to show the change of infection status in intermediate hosts after the mass chemotherapy may correspond to the duration of survival of the parasite in the intermediate hosts. With the data available presently, it is difficult to determine on what point of the curve the present status is situated (on decreasing phase or increasing phase?), how far the rate will go down if it is on decreasing phase, and how long would it take in returning to the original status without further management. The result of follow-up study, however, strongly indicate that continous and intense chemotherapy may be able to put the paragonimiasis under control. Further follow-up study on total population including survey on changes of environment and eating habits is planned.
parasitology-helminth-trematoda-Paragonimus westermani ; chemotherapy ; control ; bithionol

No abstract available.
Folliculitis* ; Hair*

Uremic pruritus is the most common skin manifestat,ion of chronic renal failure nnd cloes not respond to conventional treatment for pr uritus such as antihistamine. Although the pathophysiology of pruritus in uremia is uncliar, UVE3 phototherapy is consi(dered as the most effective and safest, therpy. We report two rases of uremic pruritus treated with LJVB. Initial doses were 70mJ, cm and 60mJ/cm. Pruritus was some relieved after two treatments and nearly completely disappeared after eight, treatments. Total doses were 840mJ/cm and 94G)mJ/
Kidney Failure, Chronic ; Phototherapy ; Pruritus ; Skin ; Uremia

Most neonatal cutaneous hemangiomatosis are complicated by visceral involvement and. are associated with a high mortality rate in the first month of life. Some neonates with multiple cutaneous hemangiomas, however, may follow a benign course of spontaneous resolution without visceral involvement. Such cases are called benign neonatal hemangiomatosis (BNH). BNH is characterized by a lack of mucosal or symptomatic visceral involvement. rapid spontaneous regression of cutaneous hemangimas, and an excellent prognosis. We report herein a case of BNH which is atypical compared to previously reported BNFI cases. Our patient had a more prolonged course than those of usual cases with BNH and showed a conjunctival involvement.
Hemangioma* ; Humans ; Infant, Newborn ; Mortality ; Prognosis

Angioedema is a disorder characterized by well-demarcated nonpitting edema involving the tongue, floor of the mouth, larynx, lips, and face. The incidence of angiotensin converting enzyme(ACE) inhibitor related angioedema has been reported to be about 0.1% to 0.2%, and the time of onset is usually during the first week of therapy. These ACE inhibitors include captopril, enalapril, and lisinopril. A 53-year old man with an 8 month history of hypertension previously controlled with atenolol, was presented to the dermatologic department with angioedema of the face and tongue. He had begun therapy with captopril one day before this episode. Even though he was treated with epinephrine and methylprednisolone sodium succinate, the edema gradually progressed and finally dyspnea developed. He was urgently intubated and treated with steroids and pheniramine maleate in the intensive care unit. The edema resolved after 24 hours.
Angioedema* ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensins ; Atenolol ; Captopril* ; Dyspnea ; Edema ; Enalapril ; Epinephrine ; Humans ; Hypertension ; Incidence ; Intensive Care Units ; Larynx ; Lip ; Lisinopril ; Methylprednisolone Hemisuccinate ; Middle Aged ; Mouth ; Pheniramine ; Steroids ; Tongue

No abstract available.
Nicotine*

index (%) in unirradiated mouse skin was 11.0+/-4.3. LI was significantly increased by tape stripping to 22.1+/-4.6. 2. The number of SBC in 1cm epidermis after 50mJ/cm UVB exposure was 28.2+/-4.1. The number of SBC was increased by tape stripping to 57.4+Cell proliferation, by evaluating sunburn cell (SBC) formation, was studied in mouse skin following tape stripping and ultraviolet light B (UVB) exposun.. 1-radiation was achieved using high pressure mercury are UVB. The results are summarized as follows. 1. Labeling 19.2. These results suggest that proliferating cells are more sensitive to UVB exposure.
Animals ; Cell Proliferation* ; Epidermis ; Mice ; Skin ; Sunburn* ; Ultraviolet Rays

No abstract available.
Amiodarone*