PURPOSE: This study was done to identify the effectiveness of the 'intervention - mother's recorded song' on low-birth weight infants in an neonatal intensive care unit (NICU). METHODS: This study was conducted with a nonequivalent control group pre-posttest quasi-experimental design and the participant group was low-birth weight infants who were admitted to the NICU. Forty-eight infants, 24 in each from two groups, the experimental and control group, participated in the study. RESULTS: For physical response according to vital signs, there were no significant statistical differences in heart rate, respiration rate and pulse oximetry saturation between the experimental group and the control group. For behavioral state, there was a significant statistical difference between the experimental and control group. CONCLUSION: The study results indicate that the intervention using mother's song had some significance as a nursing intervention with positive impacts. Such an intervention can help pediatric nurses improve infants' stabilization of their vital signs and behavioral states. By showing the effectiveness of such an intervention, the results of this study provide further evidence-based information in developing the practice of pediatric nursing.
Heart Rate ; Humans ; Infant ; Infant, Newborn ; Intensive Care, Neonatal ; Clinical Trial ; Mothers ; Oximetry ; Pediatric Nursing ; Respiratory Rate ; Singing ; Vital Signs

No abstract available.
Iron*

We made a clinical observation of 63 cases with miliary tuberculosis at the pediatric department of Hanyang University Hospital in Seoul, Korea, during the period from January, 1973 to September, 1979. The result were as folowing: 1. The incidence of miliary tubeculosis in children was 0.57%(63 cases/11,040) of total admission cases. The incidence was increased for the last 2 years, that is 0.54% in 1978 and 0.96% in 1979 respectively. 2. The highest incidence by age was noticed as 79.4% in the group under the age of 3 years with the 1 case of 2 months old. 3. The seasonal prevalence were winter and spring showing incidence of 63% 4. The source of infection was found in 49.2% of all cases, and majority (58.1%) of the infection was caused by their parents. 5. Only 9.5% of cases had received BCG innoculation. 6. The chief compalints on admission were revealed in the order of fever (71.4%), coughing (66.7%), vomiting (49.2%), irritability (25.4%), etc. 7. The principal clinical features on admission were marked emaciation (46.0%), abnormal neurologic sign (46.0%), hepatosplenobegaly (34.9%) in order. 8. The tuberculin skin test with 5TU PPD was noticed positive reaction in 54%. 9. The causative organism was isolated in 42.3% of all 26 observed cases. 10. Hematologic findings revealed mild degree of anemia (63.9%), leukocytosis (75.5%), increased ESR (63.4%). 11. Miliary density on X-ray were disappeared within 4 months following treatment in 73.9% of all 23 observed cases. 12. The complications or combined diseases were tuberculous meningitis (41 cases), cervical lymphadenopathy (10 cases) and tuberculous peritonitis (4 cases), etc. 13. The mortality rate was 14.3% (9 cases/63).
Anemia ; Child* ; Cough ; Emaciation ; Fever ; Humans ; Incidence ; Infant ; Korea ; Leukocytosis ; Lymphatic Diseases ; Mortality ; Mycobacterium bovis ; Neurologic Manifestations ; Parents ; Peritonitis, Tuberculous ; Prevalence ; Seasons ; Seoul ; Skin Tests ; Tuberculin ; Tuberculosis, Meningeal ; Tuberculosis, Miliary* ; Vomiting

PURPOSE: This study aimed to evaluate the cancer detection rate in a Korean population with prostate-specific antigen (PSA) levels greater than or equal to 20.0ng/mL. MATERIALS AND METHODS: A total of 174 men 50 to 79 years old (median 69) included in the study. The median prostate volume of the patients was 44.8mL (range 14.1 to 210.0) and their serum PSA ranged from 20.0 to 9725.0ng/mL (median 44.8). RESULTS: Of 174 men 141 (81.0%) were diagnosed with prostate cancer on initial biopsy. In the total number of patients, the positive predictive value (PPV) was 62.9% for PSA 20 to 29.9, 72.7% for PSA 30 to 39.9 and 100% for PSA 40 to 49.9 ng/mL. In patients with an abnormal digital rectal examination (DRE), the values for these PSA ranges increased to 89.5%, 91.7% and 100%, respectively. The PPV was 81.0% for PSA cutoff of 20, 89.2% for a cutoff of 30, 95.4% for a cutoff of 40, and 94.7% for a cutoff of 50 ng/mL. In conjunction with an abnormal DRE, the values for these PSA cutoffs increased to 95.9%, 98.1%, 100%, and 100%, respectively. CONCLUSION: Our data suggest the ability to predict the presence of prostate cancer reliably on initial biopsy when PSA threshold is greater than or equal to 50ng/mL. This PSA threshold may be lowered to 40ng/mL in the presence of an abnormal DRE. In Korean men with high PSA, the detection rate of prostate cancer on biopsy appears to be comparable to that for American men.
Aged ; Biopsy ; Cohort Studies ; Digital Rectal Examination ; Humans ; Korea ; Male ; Middle Aged ; Predictive Value of Tests ; Prostate/pathology ; Prostate-Specific Antigen/*blood ; Prostatic Neoplasms/*diagnosis/metabolism/pathology

40 premature(some low birth weight) infants were included for this study consisting 20 infants of SIMILAC (Ready to fed) formula fed group and 20 infants of Local product formula fed group.1) Average gestational age of SIMILAC fed group was 33.65 weeks and that of Local product formula fed group was 34.45 weeks.2) Average birth weight of SIMILAC fed group was 1774.5gm and that of Local product formula fed group was 1813gm. 3) Daly total Kcal given to the SIMILAC group was 129.2 Kcal/kg and that of Local product group was 180 Kcal/kg. 4) No weight gain was seen with 120 Kcal-145kcal/kg of Local product formula feeding during initial study period. 5) Total fluid supplied for both group were equal and that were 190ml/kg/day in each group. 6) Average number of defecation per day was 3.4 times in SIMILAC group and 2.8times in Local product group. Mild tendency to loose stool was seen at 2 babies in SIMILAC group and at 4 babies in Local product group. Mild tendency to constipation was also seen at one baby in SIMILAC group and 3 babies in Local product group. 7) Average daily weight gaining in SIMILAC group was 25gm and that of Local product group was 27.9gm.
Birth Weight ; Constipation ; Defecation ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature* ; Parturition ; Weight Gain

The purpose of this study was to develop the framework of community-based home care nursing delivery system, and to demonstrate and evaluate the efficiency of it. The study was carned out over a period of 3years from September 1996 to August 1999. The researchers developed Standards for operations, this was all aimed toward a home care recording system, and an assessment intervention algorithm for various diseases quality control and standardization. In the center, 185 patients enrolled, and of the enrollments cerebrovascular disorder and cancer were the most prevailment diseases. Also, a home care nursing activity classification was developed in six domains. Those domains were assessment, medication, treatment, education and consultation, emotional care, and referral or follow-up care. Ten sub-domains were divided according to the systematic needs. Among these nursing activities, treatment, assessment, and education and consultation were frequently performed. In sub-domain classification, skin integrity, respiration, circulation, and immobility related care were provided most frequently. The cost of home care nursing per visit was also suggested. The cost include direct and indirect nursing care, management, and transportation cost. Also, the researchers tried to overcome the limitations of hospital-based home care to provide more accessible, efficient, safe, and stable home care nursing. Therefore, clients were referred from other patients, families, public health care centers, industries, and even hospitals. As a result of this study, several limitations of operation were found. First, it was difficult to manage and communicate with doctor in the emergency situations. Second, there was too much time spent for transportation. This was because they are only five nurses, who cover all of the areas of Seoul and nearby cities. Third, preparation for special care of home care nurses was lacking. Fourth, criteria for the termination of care and the frequency of home visits were ambiguous. Finally, interconnection with home care machinery company was so yely needed. New paragraphs' strategies for solving these problems were suggested. This study will be the basis of community-based home care nursing, and the computerized information delivery system for home care nursing in Korea.
Cerebrovascular Disorders ; Classification ; Education ; Emergencies ; Home Care Services* ; Home Care Services, Hospital-Based ; House Calls ; Humans ; Korea ; Nursing Care ; Nursing Services* ; Nursing* ; Public Health ; Quality Control ; Referral and Consultation ; Respiration ; Seoul ; Skin ; Transportation

OBJECTIVE: This study was performed to identify whether growth and differentiation factor-9 (GDF-9) and transforming growth factor-beta1 (TGF-beta1) expressions would be lower in the follicular fluid (FF) of those over age 35 who underwent IVF than under age 35. METHODS: A total of 24 IVF cycles (20 patients) were included in this study. All of patients were stimulated for IVF by the GnRH short protocol and divided into two groups for analysis, according to their age: <35 group (14 cycles, 11 patients) vs. > or =35 group (10 cycles, 9 patients). The expression levels of GDF-9 and TGF-beta1 were determined by western blotting and quantitative enzyme-linked immunosorbent assay. RESULTS: The numbers of retrieved oocytes and metaphase II oocytes were significantly lower in the > or =35 group. Lower expression of GDF-9 and TGF-beta1 by western blotting in the > or =35 group were observed as well. The mean GDF-9 and TGF-beta1 levels by enzyme-linked immunosorbent assay were lower in the > or =35 group. The values were 6,850.5+/-928.4 ng/L vs. 3,333.3+/-1,089.2 ng/L of GDF-9 (p<0.05) and 3,844.1+/-571.1 ng/L vs. 2,187.7+/-754.0 ng/L of TGF-beta1 (p<0.05). A negative correlation between GDF-9 and age was observed (r=-0.546, p=0.006). CONCLUSION: GDF-9 and TGF-beta1 production from stimulated ovaries during IVF appears to decrease with age.
Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Female ; Fertilization ; Follicular Fluid ; Gonadotropin-Releasing Hormone ; Growth Differentiation Factor 9 ; Humans ; Metaphase ; Oocytes ; Ovary ; Transforming Growth Factor beta1

BACKGROUND: The cause of acrodermatitis enteropathica(AE) is closely related to zinc deficiency. Zinc is a potent inhibitor of endonuclease. Acute rises in the apoptosis in lymphoid and myeloid cell lines during zinc deficiency has recently been reported. The method of terminal transferase mediated dUTP biotin nick end labeling(TUNEL) is used in situ labelling of apoptotic nuclei in routine tissue sections. OBJECTIVE: The purpose of this study is to clarify our hypothesis that apoptosis resulted from zinc deficiency might cause keratinocytes damages in AE. METHOD: We stained 6 AE biopsy specimen with TUNEL technique. RESULTS: In acroderrratitis enteropathica, apoptotic keratinocytes were shown in the entire epidermis as compared to normal, controlled skin, in which it was found only at the uppermost layer of this stratified epithelium. CONCLUSION: This result suggests that apoptosis resulting from zinc deficiency might play a role in keratinocyte death in AE.
Acrodermatitis* ; Apoptosis ; Biopsy ; Biotin ; Epidermis ; Epithelium ; In Situ Nick-End Labeling ; Keratinocytes* ; Myeloid Cells ; Skin ; Transferases ; Zinc

PURPOSE: This study analyzed the prognostic factors affecting the survival rate and evaluated the role of radiation therapy in muscle-invading bladder cancer. MATERIALS AND METHODS: Twenty eight patients with bladder cancer who completed planned definitive radiotherapy in the Departments of Therapeutic Radiology and Urology, Chonnam National University Hospital between Jan. 1986 to Dec. 1998 were retrospectively analyzed. The reviews were performed based on the patients' medical records. There were 21 males and 7 females in this study. The median of age was 72 years old ranging from 49 to 84 years. All patients were confirmed as having transitional cell carcinoma with histological grade 1 in one patient, grade 2 in 15, grade 3 in 9, and uninformed in 3. Radiation therapy was performed using a linear accelerator with 6 or 10 MV X-rays. Radiation was delivered daily with a 1.8 or 2.0 Gy fraction size by 4 ports (anterior-posterior, both lateral, alternatively) or 3 ports (Anterior and both lateral). The median radiation dose delivered to the isocenter of the target volume was 61.24 Gy ranging from 59 to 66.6 Gy. The survival rate was calculated by the Kaplan-Meier method. Multivariate analysis was performed on the prognostic factors affecting the survival rate. RESULTS: The survival rate was 76%, 46%, 33%, 33% at 1, 2, 3, 5 years, respectively, with 19 months of median survival. The potential factors of age (less than 70 years vs above 70), sex, diabetes mellitus, hypertension, hydronephrosis, T-stage (T3a vs T3b), TUR, chemotherapy, total duration of radiotherapy, radiation dose (less than 60 Gy vs above 60 Gy), and the treatment response were investigated with uni- and multivariate analysis. In univariate analysis, the T-stage ( p=0.078) and radiation dose ( p=0.051) were marginally significant, and the treatment response ( p=0.011) was a statistically significant factor on the survival rate. Multivariate analysis showed there were no significant prognostic factors affecting the survival rate. CONCLUSION: The treatment response and radiation dose are suggeted as the statistically significant factors affecting the survival rate of muscle invasive bladder cancer. A Further prospective randomized study is needed to confirm these prognostic factors.
Aged ; Carcinoma, Transitional Cell ; Diabetes Mellitus ; Drug Therapy ; Female ; Humans ; Hydronephrosis ; Hypertension ; Jeollanam-do ; Male ; Medical Records ; Multivariate Analysis ; Particle Accelerators ; Radiation Oncology ; Radiotherapy* ; Retrospective Studies ; Survival Rate ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urology

Although heparin has over the years proven to be a reliable anticoagulant, there are still several undesirable side effects including dyslipidemia. Several recent publications have suggested that a low-molecular-weight heparin(LMWH) is superior to conventional heparin because it causes less side effects and has beneficial effects on lipid parameters. But the results of the study about lipid parameters are controversial. We conducted a prospective study to evaluate the efficacy, safetey and effect of LMWH on lipid parameters as an anticoagulant in hemodialysis therapy. 2500 a x a IU of LMWH(Fragmin ) were given to 51 maintenance hemodialysis patients (age:49.9+/-16.1, M:F=33:18) just before each dialysis for consecutive 12 hemodialysis. And 16 patients out of 51 patients were given for 6 months to compare the changes of lipid parameters with those in 22 patients with conventional heparin. The mean venous compression time and the degree of clot deposition in dialyzer were similar in both LMWH and conventional heparin group. The heparin concentration via anti-factor Xa-specific clotting method (Heptest ) in both groups was similar(0.64+/-0.24 vs 0.54+/-0.18IU/ml at 15 min, 0.32+/-0.13 vs. 0.26+/-0.24 IU/ml at 4 hours after starting hemodialysis). The hematologic parameters such as hemoglobin and platelet count level did not show any differences between the two types of heparin. The level of triglyceride was significantly decreased after 6 month by the LMWH therapy(177.6+/-60.9 vs 145.9+/-85.5mg/dl, P<0.05) but was not changed by the conventional heparin therapy(150.6+/-54.6 vs. 176.6+/-64.6, P=0.16). The level of HDL were significantly changed in both group(32.1+/-11.6 vs. 37.9+/-9.7mg/dl, P<0.05 in LMWH group , 40.4+/-11.9 vs. 33.7+/-7.8mg/dl, P<0.05 in conventional heparin group). The levels of total cholesterol and LDL-cholesterol were decreased in LMWH group but statistically insignificant. We conclude that LMWH is a suitable alternative to unfractionated conventional heparin for anticoagulation therapy and has beneficial effects on the lipoprotein profile in hemodialysis patients.
Cholesterol ; Dalteparin ; Dialysis ; Dyslipidemias ; Heparin ; Heparin, Low-Molecular-Weight* ; Humans ; Lipoproteins ; Platelet Count ; Prospective Studies ; Renal Dialysis* ; Triglycerides