The aim of this study is to evaluate the therapeutic potential of the immunostimulating adjuvant in patients with HCCs¬¬¬.46 patients with HCCs were divided into 2 groups: group I (30pts) treated by Transcatheter Oily Chemoembolization (TOCE alone), group II resulted in a better clinical improvement, decreased AFP and tumor size, and a longer mean survival time versus group I. Combined treatment demonstrated a significant increase in lymphocytes expressing CD 16-CD 56 with NK activity and followed by a rise in lymphocyte with morphological feature of cytotoxic lymphocyte ( CD8 positive) was observed
Liver Neoplasms ; Thymosin ; Therapeutics

The aim of this study is to evaluate the therapeutic potential of the immunostimulating adjuvant in patients with HCCs¬¬¬.46 patients with HCCs were divided into 2 groups: group I (30pts) treated by Transcatheter Oily Chemoembolization (TOCE alone), group II resulted in a better clinical improvement, decreased AFP and tumor size, and a longer mean survival time versus group I. Combined treatment demonstrated a significant increase in lymphocytes expressing CD 16-CD 56 with NK activity and followed by a rise in lymphocyte with morphological feature of cytotoxic lymphocyte ( CD8 positive) was observed
Liver Neoplasms ; Thymosin ; Therapeutics

56 patients with gastric ulcers were treated by triple therapy with Nexium, Ospamox and Klacid (NOK).45 days after treatment, 89.3% patients had no gastric pain; 92.8% patients had ulcer healing, HP eradication rate 94.6% at 6 months and 12 months after treatment, 95% and 93.8% patients had ulcer healing; HP eradication rate was 90% and 90.6%; gastric pain and ulcer recurrence was 7.5% and 6.3%, respectively; HP-positive return rate was 10% and 9.4%
Stomach Ulcer, Helicobacter pylori, Therapeutics

Study on prevalence of HP(+) infection and the relationship between HP(+) among children and members in a multi-generation family through 189 children and 344 adults of 99 households. The results showed that, HP seropositivity was 67.4% in adults and 41.3% in children. Some risk factors were identified such as: The seropositive mother was the highest risk factor for HP seropositivity in children and the relationship between HP(+) among children and their mother was independent with other factors. The seropositive father increased HP infective risk in children, but seropostivity in mother was more important. Children's seropositivity was significantly increased in households with  3 children, in those with > 4 persons. No association was found between HP seropositivity in children and that in their grandparents and relatives
Helicobacter pylori ; Cross Infection ; Family Characteristics ; epidemiology

In this prospective study, 685 patients with hepato cellular carcinomas were diagnosed and treated in the Central Military Hospital 108 for 4 years from Mar 2001 to Feb 2005. The resulst as: hepato cellular carcinomas often occured in males, 7 times higher than in females. The most common symptoms are pain on lower right side (80.9%), fatigue (45.5%), swollen liver (79.6%). 70.9% of patients were detected by ultrasound, 70.6% of patients were detected by computer tomography among which 51.8% with one single tumor; 38.7% with 3 or more tumors; 51% with tumors on right liver. Nearly 70% of patients had high AFP, 26.3% of patients had AFP>1000ng/ml. The accuracy of diagnosis increased to 97.5% by combination of all methods of clinical examination, ultrasound, AFP, CT scanning and fine needle aspiration cytopuncture
Liver Neoplasms ; Diagnosis

The study was aimed to assess the H. pylori infection rate and to investigate contributing factors among 105 orphans and 85 handicapped institutionalized children. H. pylori seropositivity was 71.4% (75/105) in the handicapped as compared to 41.3% (77/186) in the control. Orphan children were at the highest risk factor of affecting H. pylori in the first three years, but healthy orphan children were more likely to be infected in the first year of residence while handicapped children were more likely to be infected in the second and the third year of their residence. There was no link between lifestyle, health status and HP infection in both two groups of children
Helicobacter pylori ; child ; epidemiology

52 patients (46 males, 6 females) with esophageal varices bleeding, age from 19-84 years, who were treated at the Central Military hospital 108 from September 2002 to September 2003. The level of breakdown via endoscopy and the number of esophageal varices breakdown on 52 patients included: 5 cases with mild level, 13 cases with average and 34 cases with severe level; 7 patients at grade II, 45 grade III; 59.6% of patients in the first time of bleeding, 21.6% secondly and 19.2% ≥3 times. Treatment results: 71.2% patients had a complete hemostasis; recurrent rate was 57.7%, in which the rate was 9.6% during first month. For 2 years of followed up, mortality rates one month and 2 years after were 13.3% of 57.7%, respectively. The results indicated that the endoscopic varices ligation have good effectiveness in urgent hemostatic cases but ineffectiveness in long-term outcome.
Gastrointestinal Hemorrhage ; Esophageal and Gastric Varices ; Therapeutics

Background: The role of Helicobacter pylori live in digestive tract cause digestive disorder are confirmed. Objectives: To assess the relationship between seroprevalence of Helicobacter pylori (HP) in children and history of digestive disorders in children and their parents. Subjects and method: In this cross-sectional study, history of digestive disorders (recurrent epigastralgy at least 3 episodes in a duration at least 3 months, confirmed either by upper endoscopy or by gastric radiography with contrast or ameloration by treatment with anti - acid) was gathered using questionnaire with additional examination of individual health book, prescription or discharge certificate of a population of 818 children <15 years old in pediatric department, Bach Mai hospital and 369 children <18 in a rural commune. Seroprevalence was determined by ELISA with cut - off at 0.18 optic density. Results:Among in - patients, seroprevalence was 52.6% (20/38) in children with digestive history, significantly higher than 32.6% (254/780) in those who were without this history (p=0.013); risk for HP infection in children with the history was 4.8 higher than that in those who were without the history [OR (95% CI): 4.79 (1.62-9.16)), while the difference in HP seroprevalence was insignificant in children whose mother or father was with or without the history (p > 0.05). Among children in the community, the difference in HP seroprevalence of 72.7% (8/11) in children with and 55.0% (250/373) in those without the history was statistically insignificant (p>0.05). However, HP seroprevalence in children whose father or mother was with the history was of 71.8% (28/39) and 70.5% (31/44), respectivly, significantly higher than 43.1 % (94/318) and 45.6% (125/274) in those whose father or mother was without the history, respectively (p < 0.05). Risk for being HP seropositive in children whose father was with the history was 3.4 folds higher than those whose father was without the history [OR (95% CI): 3.36 (1.38-7.54)] and that in children whose mother was with the history was 2.9 folds higher than in those whose mother was without the history [OR (95% CI): 2.91 (1.41-5.26)]. Conclusion: It exsisted a discrepancy in relationship between HP seroprevalence in children and history of digestive disorders in 2 groups of population in the hospital and in the community, and further studies with larger size were warranted to better clarify this relationship.
Helicobacter pylori/ pathogenicity ; Stomach/ pathology ; Duodenal Diseases/ diagnosis ; pathology ; Child

Background: the selection of appropriate antibiotics decided success in healing stomach-duodenum lesions. Regimens were recommended over the world today in treatment of stomach-duodenal ulcers were combination ofthree drugs, including an anti-gastric acid secretion agent and two of three antibiotics were amoxicillin (Amox), clarithromycin (Clar) and metronidazole (Metro). In Vietnam, a recent study showed that 76% of HP strains resistant to Metro and 1% resistant to Clar. Objectives: to describe prevalence and trend of primary antibiotics resistance of H.pylori to metronidazole, clarithromycin and amoxicillin over 10 years (1993-2002). Subjectives and Method: A retrospective study was about the susceptibility of 434 HP isolates derived from 281 children and 153 adults to Metro, Clar and Amox for 10 years (1993-2002) by using E-test. Results: no isolates resistant to Amox had been identified. Overall resistance rates of HP isolates to Metro, Clar and to both of them were 48.9%, 31.5% and 17.1% (51.7%, 28.4% and 17.6% in children and 43.7%, 36.6% and 16.3% in adults). Metro resistance rate in children aged from 10 to 18 was higher than that in adults and younger children (p<0.04). Clar resistance rate of children under 10 was lower than that of older children and adults (p<0.02). Both MICs of dual resistant isolates to Metro and Clar were higher than that of single resistant isolates (p<0.02 with Metro and p<0.01 with Clar). Conclusions: resistance rates of HP isolates to Metro, Clar and to both of them were relatively high. No isolates resistant to Amox had been identified. Antibiotics resistance rates in children were difference between the ages.
Helicobacter pylori ; Drug Resistance ; Microbial ;

Background: Helicobacter pylori (HP), the main reason caused digestive disease in many people. Objectives: To explore the relationship between seroprevalence of HP in children and the duration of breastfeeding (BF) in childhood. Subjects and method:Data on BF duration were collected, using a structured questionnaires, then analyzed by logistic regression, in three different groups: (1) 764 children aged from 6 months to 15 years admitted to or visiting a tertiary teaching hospital, (2) 369 children under 18 from a rural village in the centre and (3) 408 children under 18 from a multi - ethnic village in the mountainous area of the northern part of Vietnam. HP infection was determined by ELISA technique. Results: HP seroprevalence was of 26.0% (69/265) in children breastfed longer than 6 months, significant lower than 37.4% (308/556) in children breastfed shorter than 6 months in the first group [p<0.02, OR (95% CI): 0.63 (0.41 - 0.84)]. This rate was of 39.7% (27/68) in children breastfed longer than 24 months, significant lower than 59.1 % (178/301) in children breastfed shorter than 24 months in the second group [p=0.01, OR (95% CI): 0.46 (0.27 - 0.78)]. However, in the 3rd group of different minority ethnics from mountainous area, where living and hygiene levels were low, HP seroprevalence was of 29.7% (82/276), significant higher than 20.5% (27/132) in children breastfed shorter than 12 months [p = 0.03, OR (95% CI): 1.64 (1.00 - 2.70)]. Conclusion: Long duration of breastfeeding seemed protective against HP acquisition in Kinh children but might become a risk factor for HP infection in mountainous children.
Helicobacter pylori/ pathogenicity ; Child