Objective To investigate the expression of NF-?B and its significance to sciatic nerve in diabetic rats.Methods The model of diabetes was induced by streptozotocin.The sciatic nerve conduction velocity(NCV)and NF-?B activity were observed at 1 month(DM1),3 months(DM3)and 6 months(DM6)during the experiment respectively.Results Compared with normal control group,NCV was significantly slower in DM3 and DM6 groups.There was no difference in NCV between normal control group and DM1 group.The expression of NF-?B,by electrophoretic mobility shift assay(EMSA),was markedly higher in DM groups(P