1.Giant Cardiac Rhabdomyoma with Mixed Atrial Tachycardia and Nonsustained Ventricular Tachycardia in a Newborn with Tuberous Sclerosis
The Ewha Medical Journal 2022;45(3):e5-
Cardiac rhabdomyomas are typically presented in the tuberous sclerosis. Although benign and often associated with spontaneous regression, in rare circumstances huge mass size and critical location can lead to heart failure, ventricular outflow tract obstruction and refractory tachyarrhythmias. An 1-day-old girl was diagnosed as cardiac tumor during perinatal period. At birth, transthoracic echocardiography revealed huge cardiac mass located in septal area of both ventricle measuring 34×30 mm. It protruded into the left ventricular (LV) outflow tract, potentially obstructing it. A surface ECG revealed atrial tachycardia with nonsustained ventricular tachycardia with heart rate of 217 beats per min. The tachyarrhythmias were controlled with intravenous amiodarone. Reduction of the giant cardiac mass was treated with mammalian target of rapamycin pathway inhibitor sirolimus. However, she unfortunately died at 10 days-old because of sudden cardiac arrest maybe due to LV outflow tract obstruction during therapy. Gene analysis revealed TSC2 mutation after death. (Ewha Med J 2022;45(3):e5)
2.Discrimination of Kawasaki disease with concomitant adenoviral detection differentiating from isolated adenoviral infection
Jong Han KIM ; Hye Ree KANG ; Su Yeong KIM ; Ji Eun BAN
Korean Journal of Pediatrics 2018;61(2):43-48
PURPOSE: Human adenovirus infection mimics Kawasaki disease (KD) but can be detected in KD patients. The aim of this study was to determine the clinical differences between KD with adenovirus infection and only adenoviral infection and to identify biomarkers for prediction of adenovirus-positive KD from isolated adenoviral infection. METHODS: A total of 147 patients with isolated adenovirus were identified by quantitative polymerase chain reaction. In addition, 11 patients having KD with adenovirus, who were treated with intravenous immunoglobulin therapy during the acute phase of KD were also evaluated. RESULTS: Compared with the adenoviral infection group, the KD with adenovirus group was significantly associated with frequent lip and tongue changes, skin rash and changes in the extremities. In the laboratory parameters, higher C-reactive protein (CRP) level and presence of hypoalbuminemia and sterile pyuria were significantly associated with the KD group. In the multivariate analysis, lip and tongue changes (odds ratio [OR], 1.416; 95% confidence interval [CI], 1.151–1.741; P=0.001), high CRP level (OR, 1.039; 95% CI 1.743–1.454; P= 0.021) and sterile pyuria (OR 1.052; 95% CI 0.861–1.286; P=0.041) were the significant predictive factors of KD. In addition, the cutoff CRP level related to KD with adenoviral detection was 56 mg/L, with a sensitivity of 81.8% and a specificity of 75.9%. CONCLUSION: Lip and tongue changes, higher serum CRP level and sterile pyuria were significantly correlated with adenovirus-positive KD.
Adenoviridae
;
Adenoviridae Infections
;
Adenovirus Infections, Human
;
Biomarkers
;
C-Reactive Protein
;
Discrimination (Psychology)
;
Exanthema
;
Extremities
;
Humans
;
Hypoalbuminemia
;
Immunization, Passive
;
Lip
;
Mucocutaneous Lymph Node Syndrome
;
Multivariate Analysis
;
Polymerase Chain Reaction
;
Pyuria
;
Sensitivity and Specificity
;
Tongue
3.Difference in Mean Platelet Volume between Migraine Patients with and without Aura
Su Ji BAN ; Jun Beom LEE ; Ga Heon JIN ; Won Yong KIM
Korean Journal of Family Practice 2019;9(4):389-393
BACKGROUND: Mean platelet volume (MPV) increases when platelets are activated, and it is known to increase in migraine patients. The aim of this study is to investigate whether there is a difference in MPV or platelet count between migraine patients with (MA) and without aura (MO).METHODS: Migraine patients were recruited from the out-patient department of a hospital between January 2012 and June 2017. Patients were divided into MA and MO groups. Platelet count and MPV were compared between groups, and the frequency of comorbidities such as ischemic stroke and cardiovascular disease, was investigated in both groups.RESULTS: Of the 123 patients, 46 were classified as MA, and 77 were classified as MO. The MPV of the MA group was significantly higher than that of the MO group (8.92±0.17 fL, 6.32±0.28 fL, respectively) (P=0.034). However, platelet count showed no significant difference between groups. Cardiovascular disease and ischemic stroke incidences were significantly higher in the MA group than in the MO group (ischemic stroke: 15.2%, 7.8%, respectively, P=0.027; cardiovascular disease: 10.9%, 6.5%, respectively, P=0.018).CONCLUSION: Mean platelet volume was significantly greater in the MA group than in the MO group. This may be related to the pathophysiological differences between the two conditions.
Cardiovascular Diseases
;
Comorbidity
;
Epilepsy
;
Humans
;
Incidence
;
Mean Platelet Volume
;
Migraine Disorders
;
Migraine with Aura
;
Migraine without Aura
;
Outpatients
;
Platelet Activation
;
Platelet Count
;
Stroke
4.A case of postoperative serotonin syndrome following the administration of fentanyl, palonosetron, and meperidine: A case report.
Chiu LEE ; Eun Ju KIM ; Soohyun JOE ; Jong Seouk BAN ; Ji Hyang LEE ; Ji Hyun AN
Anesthesia and Pain Medicine 2015;10(4):267-270
Serotonin syndrome is an unexpected adverse reaction of serotonergic medication. Some drugs used by anesthesiologists may cause serotonin syndrome. Serotonin syndrome is known to be related to 5-hydroxytryptamine 1A and 5-hydroxytryptamine 2A agonism. However, recent research has revealed evidence that 5-hydroxytryptamine 3 (5-HT3) antagonism can also play a role in serotonin syndrome. Among the 5-HT3 antagonists, palonosetron is the most highly specific. In this study, we present the first case of fentanyl- and meperidine-induced serotonin syndrome precipitated by palonosetron in general anesthesia.
Anesthesia, General
;
Felodipine
;
Fentanyl*
;
Meperidine*
;
Serotonin 5-HT3 Receptor Antagonists
;
Serotonin Syndrome*
;
Serotonin*
5.Severe hemodynamic deterioration caused by cardiac herniation during endoscopic thoracic sympathicotomy in a patient with previously undiagnosed congenital pericardial defect.
Joong Ho PARK ; Eun Ju KIM ; Jong Seouk BAN ; Ji Hyang LEE ; Ji Hyun AN
Korean Journal of Anesthesiology 2014;67(Suppl):S72-S73
No abstract available.
Hemodynamics*
;
Humans
6.Severe hemodynamic deterioration caused by cardiac herniation during endoscopic thoracic sympathicotomy in a patient with previously undiagnosed congenital pericardial defect.
Joong Ho PARK ; Eun Ju KIM ; Jong Seouk BAN ; Ji Hyang LEE ; Ji Hyun AN
Korean Journal of Anesthesiology 2014;67(Suppl):S72-S73
No abstract available.
Hemodynamics*
;
Humans
7.Lumbar Paraspinal Myonecrosis Following Combined Spinal Epidural Anesthesia: A case report.
Min Kyun KIM ; Ji Hyang LEE ; Eun Ju KIM ; Sang Gon LEE ; Jong Suk BAN ; Byung Woo MIN
Korean Journal of Anesthesiology 2007;53(5):683-687
A 55-year-old woman received a combined spinal epidural anesthesia for total replacement surgery of the left knee. After surgery, the epidural patient controlled analgesia (PCA) device was activated. After the first post-operative day, the patient complained of severe back pain rather than left knee pain in spite of the bolus dose of analgesics via epidural catheter. The epidural catheter was removed and intravenous PCA was initiated. On the 16th post-operative day, the patient's back and knee pain improved; however, the fever did not subside. A blood test revealed increased inflammatory markers in spite of antibiotic therapy. Under the suspicion of epidural abscess, a lumbar magnetic resonance imaging scan was performed and revealed an increase in the signal within left lumbar paraspinal muscle. A prompt debridement and irrigation of the necrotic tissues was performed. The histologic diagnosis was lumbar paraspinal myonecrosis. Subsequent to this corrective procedure, the patient's fever subsided and the inflammatory markers were normalized, except for mild back pain after the surgical repair.
Analgesia, Patient-Controlled
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Analgesics
;
Anesthesia, Epidural*
;
Back Pain
;
Catheters
;
Debridement
;
Diagnosis
;
Epidural Abscess
;
Female
;
Fever
;
Hematologic Tests
;
Humans
;
Knee
;
Magnetic Resonance Imaging
;
Middle Aged
;
Paraspinal Muscles
;
Passive Cutaneous Anaphylaxis
8.Intractable Atrial Flutter Successfully Treated with Flecainide and Propranolol in a Premature Infant.
Min Ju LEE ; Se Hwan AHN ; Jong Han KIM ; Su Yeong KIM ; Ji Eun BAN
The Ewha Medical Journal 2017;40(3):140-142
Although Atrial flutter (AFL) in newborn infant with normal cardiac anatomy has benign clinical course, an intractable AFL is associated with an increased risk of development of heart failure and sudden death, and is still difficult to manage. It requires multiple external electrical cardioversions, and it shows a poor response to antiarrhythmic drug therapy. We report a case of a premature infant with an intractable AFL, which we successfully treated with oral flecainide and propranolol in spite of recurred AFL. A 1-month-old, 34-week gestation, premature baby presented with an irregular heart beat and irritability. An AFL with 2:1 atrioventricular conduction was documented. Because of the intractable AFL, repeated electrical cardioversion and amiodarone were continued for 14 days. However, amiodarone was discontinued in favour of flecainide and propranolol because of the recurrent AFL and newly developed transient hypothyroidism. During 1-year follow-up period, in which oral flecainide and propranolol were continued, no AFL was observed.
Amiodarone
;
Atrial Flutter*
;
Death, Sudden
;
Drug Therapy
;
Electric Countershock
;
Flecainide*
;
Follow-Up Studies
;
Heart
;
Heart Failure
;
Humans
;
Hypothyroidism
;
Infant, Newborn
;
Infant, Premature*
;
Pregnancy
;
Propranolol*
9.Comparison of the Success Rates of Lightwand Tracheal Intubation on the First Attempt When Using the Lightwand at Different Angles.
Min Kyun KIM ; Ji Hyang LEE ; Eun Ju KIM ; Sang Gon LEE ; Jong Suk BAN ; Byung Woo MIN
Anesthesia and Pain Medicine 2007;2(4):252-256
BACKGROUND: It has been recommended that lightwand tracheal intubation be used for cases in which there is difficult airway management. Transillumination of the soft tissue of the neck by the lightwand can lead to successful intubation; however, this depends on skin color, obesity, head position, angle and the bent length of the lightwand. The goal of this study was to compare the success rates of intubation on the first attempt and complications of lightwand orotracheal intubation that occurred when using the lightwand at angles of 60 degrees and 90 degrees. METHODS: One hundred forty eight patients of ASA physical status 1 or 2 were enrolled in this study. Patients in whom intubation had previously been difficult as well as patients who had the potential for difficult intubation were excluded from this study. Patients were randomly assigned to one of two groups: The lightwand bent in 60 degrees (LW60) group and the lightwand bent in 90degrees (LW90) group. Anesthesia was performed using propofol (2 mg/kg), fentanyl (1microg/kg) and rocuronium (0.9 mg/kg), and lightwand orotracheal intubation was attempted 2 minutes after the induction of anesthesia. The success rates of intubation, the number of attempts and their duration, as well as hemodynamic changes, resistance to the tube and complications that occurred during the procedure were recorded. RESULTS: In the LW90 group, resistance to the tube during lightwand intubation occurred in a significant number of patients (P < 0.05), however, there were no significant differences observed between the two groups with regard to the intubation success rates on the first attempt, the duration of intubation, hemodynamic changes and complications. CONCLUSIONS: Their were no significant differences observed between intubation success rates on first attempt and complications when using a lightwand bent to 60 degrees or 90 degrees in patients without any previously known airway abnormalities.
Airway Management
;
Anesthesia
;
Fentanyl
;
Head
;
Hemodynamics
;
Humans
;
Intubation*
;
Neck
;
Obesity
;
Propofol
;
Skin
;
Transillumination
10.Dexmedetomidine combined with midazolam vs. dexmedetomidine alone for sedation during spinal anesthesia.
Douk Keun YOON ; Jong Seouk BAN ; Sang Gon LEE ; Ji Hyang LEE ; Eunju KIM ; Jihyun AN
Korean Journal of Anesthesiology 2016;69(5):446-452
BACKGROUND: Dexmedetomidine is a useful sedative agent for spinal anesthesia. However, it has been reported that dexmedetomidine decreases heart rate in a dose-dependent manner. In the current study, we compared the administration of a bolus dose of midazolam and bolus loading of dexmedetomidine over 10 min with the goal of identifying an additional method of sedation. METHODS: Ninety patients classified as American Society of Anesthesiologists physical status I–II who were undergoing spinal anesthesia were divided into two groups. In the midazolam and dexmedetomidine combined group (group MD), 10 min after bolus loading of 0.05 mg/kg midazolam, 0.5 µg/kg/h dexmedetomidine was continuously infused. In the dexmedetomidine group (group D), 1 µg/kg dexmedetomidine was infused over 10 min, and then 0.5 µg/kg/h dexmedetomidine was continuously infused. RESULTS: At 10 min, the sedation depth of the two groups was almost equal. In both groups, the bispectral index was within the optimal score range of 55–80 and the Ramsay Sedation Scale score was within the optimal range of 3–5. Satisfaction with sedation for both patient and surgeon did not differ between the two groups. At 10 min, heart rate was significantly lower (P < 0.010) in group D and mean blood pressure was significantly lower (P < 0.010) in group MD. The prevalence of bradycardia, hypotension, and hypoxia did not differ statistically between the two groups (P = 0.714, P = 0.089, P = 0.495, respectively). CONCLUSIONS: Midazolam bolus and dexmedetomidine continuous infusion (the regimen of group MD) may be an additional sedation method for patients who have severe bradycardia.
Anesthesia, Spinal*
;
Anoxia
;
Blood Pressure
;
Bradycardia
;
Dexmedetomidine*
;
Heart Rate
;
Humans
;
Hypotension
;
Methods
;
Midazolam*
;
Prevalence