Introduction: The present work was focused on the investigation of resistance of biological membranes of various herbal formulations “Adapton 6” containing of rosa cinnamomea (плоды шиповника), Crataegus sanguine Pall (боярышника), Hippophae rhamnoides L (облепихи), radix Astragalus dasyanthus Pall (корни Астрагала) (левзеи) and Rheum palmatum L (ревеня).Purpose: study of evaluation of the membranostabilizing effect of “Adapton 6”Materials and Methods: in the experiment was made from 1% suspension of cleaned erythrocytes. The hemolisis of erythrocytes was induced by Phentona (peroxide hemolise) and added distilled water (osmotic hemolisis).Result: The membranostabilzing effect defined in vitro, according to the degree of bracing of peroxide and osmotic hemolisis of erythrocytes of donor’s blood 4. Suspension erythrocytes were taken with equal volume of distilled water to get osmotic hemolisis. The studied range of concentration of membranostabilizing effect of “Adapton 6” was 0.1 mkg/ml and reducing hemolisis in 64%, comparison with control group. In the studied drug were 1.0, 0.1and 0.01 mg/ml when degree of hemolisis reduced on 42. 52 and 60%, accordingly. The peroxide hemolise established that IC50 is 0.492 mg/ml (492 mkg/ml). Also in the studied drug were 1.0, 0.1 and 0.01 percent mg/ml when degree hemolisis reduced on 32, 49 and 51 respectively. The osmotic hemolise established that IC 50 is 0.6 mg/ml (60 mkg/ml). Conclusion: On conclusion, the prepared multicomponent herbal drug “Adapton 6” has membranostabilzing effect due to reduce of peroxide and osmotic hemolisis on the erythrocytes and degranulation adipocyates.