Objective To study the clinical characteristics in patients with peptic ulcer (PU) in different nationalities and regions. Methods Retrospective analysis on the clinical data of 2473 cases of PU encountered in our hospital within past 15 years. Results The detecting rate of PU is 12.53％ ; whith the ratio of males and females 3.67:1 inwhich the detecting rates of Han and Hui nationalities are 13.42％ and 10.66％ respectively, Among them 44.4％ were duodenal ulcer,50.63％ were gastric ulcer, the ratio being 0.88:1. Conclusion The detecting rate of peptic ulcer in Han nationality is hihger than in Hui nationality , gastric ulcer occurs more often than duodenal ulcer. Episodic attacks occur mostly in spring and autumn . As to the location of ulcer in duodenal ulcer they are most on anterior wall and greater curvature of bulb; in gastric ulcer they are most on gastric angul and antrum , the peak age of incidence is 21 to 50. Bleeding is the most common complication in peptic ulcer patients.