Objective To summarize and analyze the epidemiological and clinical characteristics of hemorrhagic fever patients with renal syndrome (HFRS),so as to provide a basis for prevention and treatment.Methods The epidemiological and clinical data of 104 HFRS patients,who were treated in the First Affiliated Hospital of Harbin Medical University in 2014,were collected.The HFRS patient's age,sex,urban and rural areas,occupation and time of onset distributions,summary onset clinical manifestations,laboratory findings,treatment and outcome were analyzed retrospectively.Results Average age of the 104 cases of HFRS patients was 43.46 years old,the youngest was 12 years old and the oldest was 80 years old.Most of the patients were 30-＜50 years old,which was accounted for 54.81％ (57/104),and most of the patients were male,which was accounted for 78.85％ (82/ 104).Most of the patients lived in rural areas,which was accounted for 81.73％ (85/104).Most patients were onset in November,accounted for 19.23％ (20/104),and the least was in August,accounted for 2.88％ (3/104),and was sporadic in the rest of the year.For the clinical classification,the light type and the moderate type were the largest part,98 cases,accounted for 94.23％,while the severe type and the critically severe type were 6 cases,accounted for 5.77％.The clinical manifestations were as follows:fever majority in 94 cases,accounted for 90.38％,fatigue,aches and pain in 89 cases,accounted for 85.57％;polyuria in 88 cases,accounted for 84.62％;chemosis in 86 cases,accounted for 82.69％;skin bleeding,petechiae in 84 cases,accounted for 80.77％;oliguria in 81 cases,accounted for 77.88％.Laboratory test results were as following:87 cases of blood platelet (PLT) reduced (83.65％),74 cases of serum creatinine (sCr) increased (71.15％),74 cases of alanine aminotransferase (ALT) increased (71.15％),85 cases of aspartate transaminase (AST) increased (81.73％),96 cases of lactate dehydrogenase (LDH) increased (92.31％),and 31 cases of creatine kinase (CK) increased (29.81％).All of the 104 patients were cured,with no death.Conclusions Majority of the HFRS patients are young adults.The peak of the incidence of HFRS lies in Autumn.The proportion of the moderate type is the highest.Early diagnosis and treatment is the key to improve the prognosis of patients with HFRS.