Objective:To explore the technical points and clinical effects of breast augmentation with silicone prosthesis through inframammary fold(IMF) incision.Methods:From January 2018 to June 2019, 26 cases of patients undergoing breast augmentation in our department were collected, including 10 cases of breast hypoplasia and 16 cases of breast atrophy, ranging in age from 24 to 38 years, with an average year of 30.2. The preselection of the volume, type of prosthesis and the design of new position of IMF were based on the height, weight, breast measurements and individual demand. During the operation, after precisely dissecting the lacunae, water were injected into the circular expander to reassess the volume of prosthesis, then the final prosthesis was implanted and the inframammary fold was reconstructed. After operation, patients were given analgesic pump and combined anti-cicatricial treatment. Postoperative complications, breast morphology, incision scar, and whether the patient was satisfied with the surgical evaluation were followed up.Results:All operations were successful and the operative time ranged from 38 to 45 minutes, the drainage time was 3-4 days, the drainage volume of the unilateral space was 30-50 ml, 96 percent of the patients (25/26) were satisfied with the incision. Postoperative following up lasted from 8 months to 16 months with an average of 12 months. No complications such as hematoma, infection or capsular contracture occurred. The breast shape of 26 patients after operation was natural, erect, plump and bilaterally symmetrical. The incision scar of new IMF was not conspicuous. The patients were very satisfied with the operation effect.Conclusions:Breast augmentation through IMF incision has advantages of short operating path, accurate dissecting and hemostasis under direct vision, short operation time. During the operation, in combination with re-evaluation after the expander inflated with saline to the required prosthesis volume and reconstruction of IMF, satisfactory clinical effects can be achieved with fewer complications.

Objective:To explore the technical points and clinical effects of breast augmentation with silicone prosthesis through inframammary fold(IMF) incision.Methods:From January 2018 to June 2019, 26 cases of patients undergoing breast augmentation in our department were collected, including 10 cases of breast hypoplasia and 16 cases of breast atrophy, ranging in age from 24 to 38 years, with an average year of 30.2. The preselection of the volume, type of prosthesis and the design of new position of IMF were based on the height, weight, breast measurements and individual demand. During the operation, after precisely dissecting the lacunae, water were injected into the circular expander to reassess the volume of prosthesis, then the final prosthesis was implanted and the inframammary fold was reconstructed. After operation, patients were given analgesic pump and combined anti-cicatricial treatment. Postoperative complications, breast morphology, incision scar, and whether the patient was satisfied with the surgical evaluation were followed up.Results:All operations were successful and the operative time ranged from 38 to 45 minutes, the drainage time was 3-4 days, the drainage volume of the unilateral space was 30-50 ml, 96 percent of the patients (25/26) were satisfied with the incision. Postoperative following up lasted from 8 months to 16 months with an average of 12 months. No complications such as hematoma, infection or capsular contracture occurred. The breast shape of 26 patients after operation was natural, erect, plump and bilaterally symmetrical. The incision scar of new IMF was not conspicuous. The patients were very satisfied with the operation effect.Conclusions:Breast augmentation through IMF incision has advantages of short operating path, accurate dissecting and hemostasis under direct vision, short operation time. During the operation, in combination with re-evaluation after the expander inflated with saline to the required prosthesis volume and reconstruction of IMF, satisfactory clinical effects can be achieved with fewer complications.

Objective:To investigate the effect of different negative pressure level on drain volume after augmentation mammoplasty through inframammary fold incision, and try to put forward the appropriate negative pressure level for the best prognosis of patients.Methods:This was a randomized controlled clinical study. Patients who underwent prosthetic augmentation mammoplasty through inframammary fold incision in the Medical Beauty Center of the First Affiliated Hospital of Zhengzhou University from January 2019 to August 2021 were selected as the study subjects. Patients were divided into 4 groups by random number table method and different levels of negative pressure drainage were applied: 600 ml adjustable negative pressure drain bottle was used uniformly after operation by -80--85 kPa group, -40--60 kPa group, and -15--30 kPa group. In 0--5.2 kPa group, 300 ml drain drum was applied after operation. The criteria for drain removal was that the drain volume within 24 hours was less than 10 ml and the drainage fluid was clear. Daily drain volume, duration of drain placement, total drain volume, acceptance of the drain device and postoperative complications were recorded in the four groups. The corresponding indexes of each group were statistically analyzed by SPSS 21.0. Measurement data were expressed as Mean±SD. One-way analysis of variance was used for comparison between groups, and LSD- t test was used for pair comparison between groups. P<0.05 was considered statistically significant. Results:A total of 80 patients were included, 20 in each group. Inter-group equilibrium analysis: there was no significant difference in age, body mass index, distance from midclavicular point to nipple, distance from inferior mammary fold to nipple, and breast tissue thickness among 4 groups ( P>0.05). Evaluation of curative effect between groups: on the first and second day after operation, there was no significant difference in drain volume between -80--85 kPa group and -40--60 kPa group ( P>0.05), but there was significant difference among other groups ( P<0.05). There was significant difference in drain volume on the third day after operation, total drain volume and duration of drain placement between the four groups ( P<0.05). The lower the negative pressure level was, the less drain volume on the third day after surgery and the less total drain volume, and the shorter duration of drain placement. The duration of drain placement of the four groups were (5.6±0.7) d (-80--85 kPa group), (4.8±0.5) d (-40--60 kPa group), (4.0±0.5) d (-15--30 kPa group), and (3.2±0.4) d (0--5.2 kPa group), respectively. Safety evaluation: the complication rate of -80--85 kPa group, -40--60 kPa group, -15--30 kPa group and 0--5.2 kPa group were 2.5% (1/40), 2.5% (1/40), 0(0/40) and 15.0% (6/40), respectively. The complication rate of 0--5.2 kPa group was the highest. Investigation on the acceptance of the drainage device (no impact/dissatisfaction): 75 patients expressed dissatisfaction, with a dissatisfaction rate of 93.75%(75/80). Conclusion:In augmentation mammoplasty through inferior fold incision low negative pressure provides less drain volume, shorter drain placement. Negative pressure between -15 to -30 kPa is optimal.

In the past decades, great progress has been made in cartilage regeneration. The traditional techniques for constructing tissue engineering cartilage scaffold mainly include pore agent method (or template method ) , phase separation method, gas foaming method, freeze-drying method , electrospinning method, etc. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate the high anisotropy of cartilage. Therefore, functional regeneration of cartilage is challenging. With the progress of three-dimensional (3D) printing technology, it is possible to prepare functional bionic scaffolds with fine structure and gradient changes through co deposition of biomaterials, cells and active biomolecules, so as to achieve functional cartilage regeneration. This article reviews 3D printing technology of cartilage tissue engineering, and the application of 3D printing technology in cartilage regeneration at different anatomical positions (articular cartilage, auricle cartilage, nasal cartilage) . In addition, the importance of preparing bionic constructs with regional structure gradient and regional composition gradient was discussed. 3D bioprinting technology, 4 D printing techniques, smart biomaterials brought hope for the construction of bionic tissues and organs.

In the past decades, significant progress has been achived in cartilage regeneration. The traditional techniques for constructing tissue engineering cartilage scaffold mainly include pore agent method (or template method), phase separation method, gas foaming method, freeze-drying method, electrospinning method, etc. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate the high anisotropy of cartilage. Therefore, functional regeneration of cartilage is challenging. With the progress of three-dimensional(3D) printing technology, it is possible to prepare functional bionic scaffolds with fine structure and gradient changes through co-deposition of biomaterials, cells and active biomolecules, so as to achieve functional cartilage regeneration. This article reviewed 3D printing technology of cartilage tissue engineering, and the application of 3D printing technology in cartilage regeneration at different anatomical positions (articular cartilage, auricle cartilage, nasal cartilage). In addition, the importance of preparing bionic constructs with regional structure gradient and regional composition gradient was discussed. 3D bioprinting technology, 4D printing techniques, smart biomaterials brought hope for the construction of bionic tissues and organs.

Objective:To investigate the effect of different negative pressure level on drain volume after augmentation mammoplasty through inframammary fold incision, and try to put forward the appropriate negative pressure level for the best prognosis of patients.Methods:This was a randomized controlled clinical study. Patients who underwent prosthetic augmentation mammoplasty through inframammary fold incision in the Medical Beauty Center of the First Affiliated Hospital of Zhengzhou University from January 2019 to August 2021 were selected as the study subjects. Patients were divided into 4 groups by random number table method and different levels of negative pressure drainage were applied: 600 ml adjustable negative pressure drain bottle was used uniformly after operation by -80--85 kPa group, -40--60 kPa group, and -15--30 kPa group. In 0--5.2 kPa group, 300 ml drain drum was applied after operation. The criteria for drain removal was that the drain volume within 24 hours was less than 10 ml and the drainage fluid was clear. Daily drain volume, duration of drain placement, total drain volume, acceptance of the drain device and postoperative complications were recorded in the four groups. The corresponding indexes of each group were statistically analyzed by SPSS 21.0. Measurement data were expressed as Mean±SD. One-way analysis of variance was used for comparison between groups, and LSD- t test was used for pair comparison between groups. P<0.05 was considered statistically significant. Results:A total of 80 patients were included, 20 in each group. Inter-group equilibrium analysis: there was no significant difference in age, body mass index, distance from midclavicular point to nipple, distance from inferior mammary fold to nipple, and breast tissue thickness among 4 groups ( P>0.05). Evaluation of curative effect between groups: on the first and second day after operation, there was no significant difference in drain volume between -80--85 kPa group and -40--60 kPa group ( P>0.05), but there was significant difference among other groups ( P<0.05). There was significant difference in drain volume on the third day after operation, total drain volume and duration of drain placement between the four groups ( P<0.05). The lower the negative pressure level was, the less drain volume on the third day after surgery and the less total drain volume, and the shorter duration of drain placement. The duration of drain placement of the four groups were (5.6±0.7) d (-80--85 kPa group), (4.8±0.5) d (-40--60 kPa group), (4.0±0.5) d (-15--30 kPa group), and (3.2±0.4) d (0--5.2 kPa group), respectively. Safety evaluation: the complication rate of -80--85 kPa group, -40--60 kPa group, -15--30 kPa group and 0--5.2 kPa group were 2.5% (1/40), 2.5% (1/40), 0(0/40) and 15.0% (6/40), respectively. The complication rate of 0--5.2 kPa group was the highest. Investigation on the acceptance of the drainage device (no impact/dissatisfaction): 75 patients expressed dissatisfaction, with a dissatisfaction rate of 93.75%(75/80). Conclusion:In augmentation mammoplasty through inferior fold incision low negative pressure provides less drain volume, shorter drain placement. Negative pressure between -15 to -30 kPa is optimal.

In the past decades, great progress has been made in cartilage regeneration. The traditional techniques for constructing tissue engineering cartilage scaffold mainly include pore agent method (or template method ) , phase separation method, gas foaming method, freeze-drying method , electrospinning method, etc. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate the high anisotropy of cartilage. Therefore, functional regeneration of cartilage is challenging. With the progress of three-dimensional (3D) printing technology, it is possible to prepare functional bionic scaffolds with fine structure and gradient changes through co deposition of biomaterials, cells and active biomolecules, so as to achieve functional cartilage regeneration. This article reviews 3D printing technology of cartilage tissue engineering, and the application of 3D printing technology in cartilage regeneration at different anatomical positions (articular cartilage, auricle cartilage, nasal cartilage) . In addition, the importance of preparing bionic constructs with regional structure gradient and regional composition gradient was discussed. 3D bioprinting technology, 4 D printing techniques, smart biomaterials brought hope for the construction of bionic tissues and organs.

In the past decades, significant progress has been achived in cartilage regeneration. The traditional techniques for constructing tissue engineering cartilage scaffold mainly include pore agent method (or template method), phase separation method, gas foaming method, freeze-drying method, electrospinning method, etc. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate the high anisotropy of cartilage. Therefore, functional regeneration of cartilage is challenging. With the progress of three-dimensional(3D) printing technology, it is possible to prepare functional bionic scaffolds with fine structure and gradient changes through co-deposition of biomaterials, cells and active biomolecules, so as to achieve functional cartilage regeneration. This article reviewed 3D printing technology of cartilage tissue engineering, and the application of 3D printing technology in cartilage regeneration at different anatomical positions (articular cartilage, auricle cartilage, nasal cartilage). In addition, the importance of preparing bionic constructs with regional structure gradient and regional composition gradient was discussed. 3D bioprinting technology, 4D printing techniques, smart biomaterials brought hope for the construction of bionic tissues and organs.

Objective To explore the effects of transtheoretical model-based intervention plan on the quality of life in patients with laryngeal cancer.Methods Totally 67 patients with laryngeal cancer who received surgery between January and June 2016 in Harbin Medical University Cancer Hospital were selected as the control group,and 71 patients who received surgery between July and December 2016 as the experimental group by purposive sampling.Patients in the control group received conventional interventions,while patients in the experimental group received transtheoretical model-based interventions.The phonic function and quality of life were compared between the two groups.Results The patients in the experimental group showed improved fundamental frequency and fundamental frequency perturbation compared to the patients in the control group post intervention (P ＜ 0.05).And the patients in the experimental group scored higher in physical,psychological,social function,feature modules and total score of quality of life than the patients in the control group (P ＜ 0.05).Conclusions The transtheoretical model-based intervention plan helps to improve the patients' phonic function and quality of life,thus worthy of application.