A 39-year-old woman presented at InternalMedicine Department of Second Clinical Hospital withepigastric pain associated with nausea,anorexia, generalized malaise, and insomnia. She had no otherimportant symptoms, and her personaland family antecedents for gastrointestinal disorders,abdominalsurgery, other diseases, or previous hospitalizationwere negative. Physical examination was normalexceptfor mild abdominal tenderness in epigastrium.Upper endoscopy observed multiple erosions in antrum of stomach.(Figure 1). Gastric biopsieswereperformed, and histopathological analysis resulted in ulcerative changes. Laboratory investigationsrevealed normal hemoglobin,hematocrit, white blood cell count, and liver and kidneyfunction. Syphilisserologies were positive for TPHA and RPR. Based on laboratory and endoscopic findings GastricSyphilis was diagnosed.The patient was treated with 2.400.000 UI dose ofpenicillin, leading to resolution of his clinical complaintsand endoscopic findings (Figure 3).

IntroductionGenotype 1 infection has been historically difficult to treat, but multiple recent studies have showntreatment results greater than high in these genotype 1b patients using well-tolerated, all-oral regimensconsisting of new direct-acting antiviral agents.GoalPurpose of the study was to define the effects of ledipasvir/sofosbuvir treatment on patients with HCVgenotype 1b infection.Materials and MethodsIn this study we enrolled 2 treatment-naive and 66 treatment-experienced, totally 68 patients who tookledipasvir/sofosbuvir during the period from January 2016 to March 2016. We used randomly selectedand double-blinded method in our clinical research. The descriptive and non-parametrical statisticaltests were conducted using SPSS Statistics 20.0.ResultsThe SVR12 and SVR24 rates were greater than 95% and no differences were observed in treatmentnaiveversus treatment-experienced patients.ConclusionTheSVR12 rates were found in 98.6% while the SVR24 was in 97.1% of 68 patients. Only 2.9% of thetotal cases were appeared relapse of HCV infection. These findings indicated needs of further studieson long-term effects of ledipasvir/sofosbuvir.