Microglia(MG)is recognized as the main immune effector in central nervous system injury and disease.MG can regulate the tumorigenesis and development of brain metastases tumor(BMT)by different ways.Studing the roles and mechanisms of MG in BMT will provide new insights into the prevention and treatment of BMT.

Objective To determine the expressions of transcription factor activator protein-2α (AP-2α), estrogen receptor-β (ER-β) and matrixmetalloproteinase-9 (MMP-9) in lichen planus (LP) lesions and their significance. Methods Tissue samples were resected from the lesions of 30 patients with LP and normal skin of 30 human controls. An immunohistochemical method using streptavidin-peroxidase (SP) was performed to detect the expression of ER-β and MMP-9, reverse transcription-PCR and Western blot to measure the mRNA and protein expressions of AP-2α, ER-β and MMP-9 in these specimens. Results There was a significant decrease in the mRNA expressions of AP-2α (0.488 ± 0.039 vs. 1.008 ± 0.023, P < 0.01 ) and ER-β (0.365 ± 0.032 vs. 0.998 ± 0.036, P < 0.01), together with an increase in the expression of MMP-9 (1.237 ± 0.027 vs. 0.567 ± 0.015, P< 0.01) in the LP lesions compared with the control specimens; similar results were observed for the protein expressions of AP-2α, ER-β and MMP-9. In LP lesions, the expression of AP-2α was positively correlated with that of ER-β (R = 0.89, P < 0.01), but negatively correlated with that of MMP-9 (r = -0.91, P < 0.01). Conclusions The down-regulation of ER-β expression and up-regulation of MMP-9 expression may be ascribed to the abnormal regulation of upstream target genes mediated by the decreased expression of AP-2α, which may be involved in the pathogenesis of LP.

Arthritis, Juvenile ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

[Objective] To guide the health preservation more scientifically and effectively through discussing relationship between natural timing and spirit-regulating, and studying the influence of lifecycle and time sequence regularity on the spirit-regulating. [Methods] The relationship of body and spirit, time property of the spirit, time sequence regularity and those lifecycle were adopted to analyse the theoretical basis and specific measures on regulating spirit based on time differentiation. [Results] Body as well as the spirit would be followed by the changes of the time sequence regularity, also at different stages of human body, the spirit changed with it accordingly. [Conclusion] TCM holds that body and spirit are unified, the lifecycle and natural timing affect human body and spirit correspondingly, so if we know the relation of the spirit and time, regulate spirit by time differentiation, which must be helpful for keeping good mind, even for health and longevity.

Cancer-related fatigue survivors have been found to have lower morning serum cortisol levels, flattened diurnal cortisol cy-cles, and decreased cortisol responses to psychological stress. The mechanism may be related to the inflammation caused by disorder of hy-pothalamus-pituitary-adrenal axis, and there are also some evidences to support that cortisol can be used to reduce cancer-related fatigue. This study introduced the research progress of the relationship between cancer-related fatigue and hypothalamus-pituitary-adrenal axis.

The fresh cadavers were injected with A. B. S into the popliteal arteries. We have studied the micro-vascular structure of this skin area under scanning electron microscope. There are 5 layers of the vascular network in this skin area. They were formed by the small branches coming from either the direct or indirect cutaneous arteries. The 5 layers are as follows: The capillary network of the papillary layer. The vascular network of the subpapillary layer. The deep dermal network. The network in the subcutaneous tissue. The network in the deep fascia tissue. It is clear that each layer of the vascular network has it's -own special character.

Choroidal neovascularization (CNV) is the key characteristic of neovascular age-related macular degeneration (nAMD),and the effective therapy is intravitreal injection of anti vascular endothelial growth factor (VEGF) agents based on clinical and basic research.In the meantime the challenge is how to further improve the inhibiting effect for CNV and visual function of anti-VEGF treatment on nAMD.The new strategy and drug delivery devices for anti-VEGF treatment will optimize the clinical scheme.From bench to bedside,the research on targeted treatment of angiogenesis brings the bloom of nAMD medical therapy.

Objective To evaluate the efficacy of CHOP (cyclophosphamide,doxorubicin,vincristine,and prednisone)chemotherapy on peripheral T cell lymphomas-unspecified (PTCL-U)in patients aged 80 years and over,and investigate the chemotherapy adverse effects and its prognostic factors.Methods Clinical data of 57 patients with PTCL-U confirmed by pathology and immunohistochemistry in Guangzhou First People's Hospital from January 2008 to January 2015 were retrospectively analyzed.The efficacy and adverse effects of CHOP chemotherapy,and its prognostic factors were evaluated.Results Of 57 patients,11 (19.3％) achieved complete remission,23(40.4％)had partial remission,14(24.6％)had stable disease,and 9(15.8％)had progressive disease after CHOP chemotherapy,with a total effective rate of 59.6％ (34 cases).The expected 1-year,2-year and 3-year overall survival(OS)rate was 70.2％ (40 cases),36.8％ (21 cases) and 17.5％ (10 cases),respectively.The median survival time was 18.2 months.Among the 57 patients,40(70.2％) had hypoplasia of bone marrow at degree Ⅰ-Ⅱ,17 (29.8％) at degree Ⅲ-Ⅳ,49 (86.0％) had mild nausea and vomiting(degree Ⅰ-Ⅱ),8(14.0％)had severe nausea and vomiting(degree Ⅲ-Ⅳ),7 had liver dysfunction,2 had cardiac toxicity and 7 had disturbance of blood coagulation.Univariate analysis showed that the alkaline phosphatase,Ki-67 percentage,lymphoma international prognostic index(IPI)score,extranodal involved sites(＞1),as well as the efficacy and course of chemotherapy were the prognostic factors for survival time in very elderly patients.Multivariate analysis indicated that IPI score＞2(95％CI:1.12～6.35,x2 ＝5.45,P＜0.01),extranodal involved sites(＞1)(95％ CI:2.58-15.32,x2 ＝ 16.42,P＜0.01),disease progression(95％CI:1.82～12.15,x2 ＝ 10.23,P＜0.01),chemotherapy courses(＞4) (5％CI:0.18～0.79,x2 ＝7.28,P＜0.01)were the independent prognostic factors for the median survival time in very elderly patients.Conclusions PTCL U patients aged 80 years and over have poor prognosis.CHOP chemotherapy has a certain effect on PTCL-U in very elderly patients,and chemotherapy side effects can be tolerated.IPI score＞2 and extranodal involved sites(＞ 1)are the important prognostic factors in very elderly PTCL-U patients.The completion of full course of chemotherapy with remission occurrence is important to prolong survival time in very elderly PTCL-U patients.

Objective:To explore the therapeutic effect of the use of budesonide for externally-used budesonide in the surgical cavities following endoscopic sinuous surgery(ESS).Method:122 cases with chronic sinusitis were randomly divided into two groups treated by the routine procedures after endoscopic sinuous surgery but the treatment group with 61 cases were treated by the addition of budesonide suspension for inhalation in the surgical cavities.The process of the epithelization in the surgical cavities by endoscopy was investigated.Result:The process of cleaning in 15 days in the surgical cavities was better in the budesonide-using group than in the controlled group.A significant difference was found(P