This study was performed to evaluate the tensile bond strength and modulus of elasticity of three permanent soft denture liners (Molloplast B , Ufi Gel C , Tokuyama ) before and after thermocycling. And their water sorption were also evaluated. Each soft denture liner was bonded to PMMA denture base resin blocks and the tensile bond strength and modulus of elasticity were measured by using universal testing machine. For the water sorption, weight measured after immersion of soft denture liners in 37+/-1degrees C water bath for 4 weeks. The results were as follows : 1. Molloplast B had the highest tensile bond strength, while Tokuyama had the lowest tensile bond strength, There was no significant difference between Tokuyama and Molloplast B in the both nonthermocycling and thermocycling. There was significant difference in tensile strength of Tokuyama before and after thermocycling(p<0.05). 2. For the modulus of elasticity, there was no significant difference between Ufi Gel C and Tokuyama in the both nonthermocycling and thermocycling. There was significant difference in modulus of elasticity of Tokuyama before and after thermocycling(p<0.05). 3. The failure modes of Molloplast B and Ufi Gel C were nainley adhesive type and that of Tokuyama was mainly mixed type in case of nonthermocycling and cohesive type after thermocycling. 4. The water sorption of each soft liners was within+/-2% in times (p<0.05) but, there was no significant difference among the soft liners in times.
Adhesives ; Baths ; Denture Bases ; Denture Liners* ; Dentures* ; Elastic Modulus ; Immersion ; Polymethyl Methacrylate ; Tensile Strength ; Water

No abstract available.
Animals ; Binding Sites* ; Carbon Monoxide* ; Carbon* ; Rats* ; Serotonin*

Purpose: This study was conducted to investigate unmet needs and sexual distress of gynecological cancer patients according to the period following immediately, 6, 12, 18, and 24 months after initial treatment. Methods: The study design was a cross-sectional comparative study, and the data collection was done from April to December 2020. The study subjects comprised a total of 212 gynecological cancer patients. The 212 subjects were grouped and evaluated as follows: 41 in immediately, 38 in 6 months, 46 in 12 months, 43 in 18 months, and 44 in 24 months after initial treatment. Results: There was a significant difference between the groups of five periods after initial treatment in the unmet needs of the subjects. As a result of post-hoc test, the unmet needs were significantly higher after 6 months than after 12, 18, and 24 months. There was a significant difference between the groups of five periods after initial treatment in sexual distress, and sexual distress after 6 months was the highest. Conclusion In this study, it was found that the unmet needs and sexual distress at the time of 6 months after initial treatment in gynecological cancer patients were high. In particular, nursing interventions, such as patient teaching and counseling are necessary for gynecological cancer patients who have reached 6 months after initial treatment.

OBJECTIVE: This study aimed to test the possible association between Cholecystokinin B receptor (CCKBR) promoter gene and panic disorder. METHODS: 262 patients with panic disorder and 76 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-based method. RESULTS: Allele distribution of CT repeat polymorphism in patients with panic disorder was not different from those of the controls. However, after excluding the patients with panic disorder comorbid with major depressive disorder and other anxiety disorder, we found out the significant association of CCKBR (CT)n repeat with the panic disorder without comorbidities. And we analysed the data as a di-allelic polymorphism with a short (140-162 bp) and a long (164-180 bp) allele. In the di-allelic analysis, there was an excess of the shorter allele in patients with panic disorder. CONCLUSION: The present study suggested that the CCKBR promoter dinucleotide polymorphism may have a potential role for susceptibility to panic disorder in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.
Alleles ; Anxiety Disorders ; Cholecystokinin* ; Comorbidity ; Depressive Disorder, Major ; Diagnosis* ; Drug Therapy* ; Humans ; Panic Disorder* ; Panic* ; Receptor, Cholecystokinin B*

In this paper, the current status of adolescent suicide prevention and intervention are addressed, including areas related to medicine, counseling, mental health nursing, social welfare, and education. Many preventive efforts and intervention programs have been developed and implemented, but the results have been mostly minimal or unfruitful and many problems arose. First, there is a lack of epidemiological research and developmentally appropriate data on adolescent suicide. Thus evidence-based research on adolescent suicide necessary to make important decisions regarding prevention strategies and the allocation of budgets and human resources is not available. Second, there are only a handful of experts with an appropriate level of education and training. Current suicide prevention efforts are performed as a part of crisis intervention, but only a few persons know how to do so effectively. Finally, a good networking and referral system among each area of service is needed. One of the most important issues might be balancing the levels of service available to each subject and to provide a proper, systematized intervention and continuous crisis management services. In order to create an effective networking and referral system among several service providers for adolescent suicide prevention, we need robust support from the Korean government and local communities.
Adolescent ; Budgets ; Counseling ; Crisis Intervention ; Hand ; Humans ; Mental Health ; Referral and Consultation ; Social Welfare ; Suicide

CATCH 22 is a medical acronym for cardiac defects, abnormal faces, thymic hypoplasia, cleft palate, and hypocalcemia, and a variable deletion on chromosome 22. It includes DiGeorge syndrome, conotruncal anomaly face syndrome, and velo-cardio-facial syndrome. It has a prevalence estimated at 1:3,000-1:6,000. Most deletions occur at de novo, but autosomal dominant inheritance is observed in 6-10% of cases. Hormonal disorders are common in patients with CATCH22 syndrome. While hypoparathyroidism was the predominant endocrine disturbance that has been documented in the DiGeorge syndrome, other hormonal defects, such as growth hormone deficiency, hypothyroidism, and hyperthyroidism have been occurred in patients with CATCH22 syndrome. The spectrum of parathyroid gland dysfunction in this syndrome ranges from severe neonatal hypocalcemia to normal parathyroid function. Most patients are usually diagnosed in young age, but a few patients with mild abnormality are presented later in life. We report a case of CATCH22 syndrome with normal parathyroid hormone and calcium level in an adult. The diagnosis of CATCH22 syndrome was confirmed by fluorescence in situ hybridization analysis.
Adult ; Calcium ; Chromosomes, Human, Pair 22 ; Cleft Palate ; DiGeorge Syndrome ; Fluorescence ; Growth Hormone ; Humans ; Hyperthyroidism ; Hypocalcemia ; Hypoparathyroidism ; Hypothyroidism ; In Situ Hybridization ; Parathyroid Glands ; Parathyroid Hormone ; Prevalence ; Wills

The anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG) were investigated in vitro and in vivo using croton oil-induced inflammation models. Croton oil (20 microgram/mL) up-regulated mRNA expression of cyclooxygenase (COX)-I and COX-II in the macrophage cell line, RAW 264.7, resulting in the release of high concentrations of prostaglandin E2 (PGE2). EAG (1~10 microgram/mL) markedly suppressed croton oil-induced COX-II mRNA expression and PGE2 production. Application of croton oil (5% in acetone) to mouse ears caused severe local erythema, edema and vascular leakage, which were significantly attenuated by oral pre-treatment with EAG (50~500 mg/kg). Croton oil dramatically increased blood levels of interleukin (IL)-6 and PGE2 without affecting tumor-necrosis factor (TNF)-alpha and nitric oxide (NO) levels. EAG pre-treatment remarkably lowered IL-6 and PGE2, but did not alter TNF-alpha or NO concentrations. These results indicate that EAG attenuates inflammatory responses in part by blocking the COX-PGE2 pathway. Therefore, EAG could be a promising candidate for the treatment of inflammatory diseases.
Angelica/*immunology ; Animals ; Cell Line ; Cyclooxygenase 1/genetics/*immunology ; Cyclooxygenase 2/genetics/*immunology ; Dinoprostone/genetics/immunology ; Inflammation/drug therapy/enzymology/*immunology ; Interleukin-6/blood ; Macrophages ; Male ; Mice ; Mice, Inbred ICR ; Nitric Oxide/blood ; Phytotherapy/*methods ; Plant Extracts/*pharmacology/therapeutic use ; Plant Roots/immunology ; RNA, Messenger/chemistry/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Necrosis Factor-alpha/blood

PURPOSE: To determine changes in subfoveal choroidal thickness (SCT) after intravitreal injection of bevacizumab in eyes with macular edema secondary to retinal vein occlusion (RVO). METHODS: Forty-four patients treated with intravitreal bevacizumab for unilateral macular edema due to RVO were retrospectively reviewed. Before injection, patients underwent best-corrected visual acuity (BCVA) assessment, dilated fundus examination, fluorescein angiography, and enhanced depth imaging optical coherence tomography. Changes in BCVA, SCT, and central macular thickness (CMT) of the RVO eyes were evaluated and compared with those of the normal contralateral eyes at baseline and at 1, 3, and 6 months after injection. RESULTS: The mean SCT in RVO eyes (265.41 ± 43.02 µm) was significantly thicker than that in the fellow eyes (244.77 ± 30.35 µm) at baseline (p < 0.001). The mean SCT was significantly reduced at 1, 3, and 6 months after intravitreal bevacizumab injection (all p < 0.001), and the change in SCT was significantly correlated with the change in CMT (r = 0.327, p = 0.030). While there was an improvement in BCVA together with a reduction in SCT (p < 0.001), no significant correlation was found (p = 0.126). CONCLUSIONS: Subfoveal choroidal thickness in RVO eyes with macular edema was greater than that in the normal fellow eyes, and decreased significantly after intravitreal bevacizumab injection. The SCT reduction was significantly correlated with CMT reduction.
Bevacizumab ; Choroid ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Macular Edema ; Retinal Vein Occlusion ; Retinal Vein ; Retinaldehyde ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity

BACKGROUND AND OBJECTIVES: A number of studies have documented that the incidence of otitis media with effusion (OME) is greater than 90% in children with cleft palates. The purpose of this study was to evaluate the correlation of OME and mastoid pneumatization in children with cleft palate. SUBJECTS AND METHOD: We studied 175 ears in 95 patients. They were categorized into three groups according to otologic finding:normal children (38 ears), children with OME (89 ears), children with cleft palates (38 ears). The mastoid pnuematization was graded into 5 groups. RESULTS: The masoid pneumatization was relatively good in 76.3% of normal children. The mastoid pneumatization was poor in 40.4% of the children with OME. All children with cleft palate had OME in both ears and their mastoid pneumatizations were very poor, with 16.7% of grade IV and 83.3% of grade V. CONCLUSION: The mastoid pneumatization of children with cleft palate was very poor compared to those without cleft palate. We believe that mastoid pneumatization was influenced by the disease of middle ear and mastoid, environmental factors. Special consideration is needed to deal with otologic problems in children with cleft palate.
Child* ; Cleft Palate* ; Ear ; Ear, Middle ; Humans ; Incidence ; Mastoid ; Otitis Media with Effusion* ; Otitis Media* ; Otitis* ; Temporal Bone*

OBJECTIVE: This study analyzed clinical courses to investigate the effectiveness of strategies switching to aripiprazole. METHODS: Patients confirmed DSM-IV diagnoses of schizophrenia who had been treated with aripiprazoleafter switching from previous antipsychotics were recruited from inpatient and outpatient departments of Inha Hospital from March 2005 to February 2007. We classified patients according to three switching strategies (crosstapering, abrupt-switching, tapering-switching) and, over the course of a one-year period, collected data for intervals during which medications were being switched. RESULTS: A total of 48 patients with an average age of 36.25+/-8.58 years participated in this study. The sample consisted of 20 patients in the cross-tapering group, 23 in the abrupt-switching group, and five in the tapering-switching group. The previous antipsychotics were risperidone, olazapine, amisulpride, quetiapine, and ziprasidone. The reasons for switching included weight gain (26.1%), hyperprolactinemia (23.9%), lack of effectiveness (20.8%), and over-sedation (13.0%). The rates at which patients continued aripiprazole after one year were 55% (11/20) for the cross-tapering group, 48.7% (11/23) for the abrupt-switching group, and 40% (2/5) for the tapering-switching group. In addition, 25% of cross-tapering patients (5/20), 43.5% of abrupt-switching patients (10/23), and 60% of tapering-switching patients (3/5) switched to other antipsychotics. Continuation of aripiprazole was higher in the cross-tapering group than in the abrupt switching group, but this difference did not reach statistical significance (p=0.351). The average aripiprazole retention duration was 10.75+/-3.29 months in the cross-tapering group, 10.39+/-3.29 months in the abrupt-switching group, and 10.00+/-4.77 months in the tapering-switching group. Cross-tapering was associated with a relatively longer retention period, but this difference did not reach statistical significance (p=0.653). CONCLUSION: All three switching strategies were associated with tolerable clinical outcomes after the shift to aripiprazole. The rate and duration of aripiprazole retention was higher in the cross-tapering group than in the abrupt switching group, but this result did not achieve statistical significance.
Antipsychotic Agents ; Diagnostic and Statistical Manual of Mental Disorders ; Dibenzothiazepines ; Humans ; Hyperprolactinemia ; Inpatients ; Outpatients ; Piperazines ; Quinolones ; Retention (Psychology) ; Risperidone ; Schizophrenia ; Sulpiride ; Thiazoles ; Weight Gain ; Aripiprazole ; Quetiapine Fumarate