No abstract available.

No abstract available.
Animals ; Binding Sites* ; Carbon Monoxide* ; Carbon* ; Rats* ; Serotonin*

No abstract available.
Facial Bones* ; Humans

The spine fracture of osteoporotic patients is considered as meaningful since it occurs prior to other life-threatening fractures (for example; fracture of proximal of femur). The purpose of this study were to analyze the relationship between BMD and spine fracture in patients who complained of back pain without any obvious trauma history. We studied the cases of one hundred thirty patients above an age of sixty years, whose visited the Department of Orthopaedic Surgery at Kosin University Medical Center, from March 1995 to April 1996. Both simple X-ray and Dual Energy X-ray Absorptiometry (DEXA) were checked in old patients. The following results were obtained. 1. The BMD of spine fracture group with the osteoporosis (mean; -3.66 standard deviation (SD)) was significantly lower than the nonfracture group (mean; -2.38 standard deviation (SD)) (P = 0.0000). 2. According that the BMD Z-score is decreased, the proportion of spine fracture is increased significantly (above-1.0SD; 16.67%, -1.0SD~ -2.0SD; 16.67%, -2.0SD~ -3.0SD; 37.83%, - 3.0SD~ 4.0SD; 51.61%, below -4.0SD; 61.54% (P = 0.000)). 3. The probability of developing the spine fracture based on above -2.0 standard deviation (SD) was 2.8 times in -2.0SD~ -3.0SD (P = 0.044), 5.3 times in -3.0SD~ -4.0SD (P = 0.004), and 7.9 times below -4.0SD (P = 0.001). We recommended more intensive treatment to the osteoporotic patients below -2.0 SD in BMD Z- score.
Absorptiometry, Photon ; Academic Medical Centers ; Back Pain ; Humans ; Middle Aged* ; Osteoporosis ; Spine*

No abstract available.
Krukenberg Tumor*

No abstract available.
Krukenberg Tumor*

A 43-year-old woman presented with numerous cutaneous neurofibromas, limited to the left anterior chest(T2-3) and the right lower back(L1-2). These had been present for 10 years. Neither cafe-au-lait spot, intertriginous freckle, nor Lisch nodule was found. The family history was negative for neurofibromatosis. Biopsy specimens showed circumscribed, nonencapsulated neurofibromas. The present case was a rare form of bilateral segmental neurofibromatosis in that while most of the reported cases involved the same dermatome bilaterally, she had bilaterally different dermatomal neurofibromas.
Adult ; Biopsy ; Cafe-au-Lait Spots ; Female ; Humans ; Melanosis ; Neurofibroma ; Neurofibromatoses*

HIV-1 p24 was cloned into multiple cloning site of pMV261, extrachromosomal expression vectors carrying BCG replication origin and BCG-specific heat-shock promoter, and then introduced into BCG and E. coli. Western blot experiments showed that the p24 efficiently expressed in recombinant BCG (rBCG), but not in E. coli. Recombinant p24 expression induced by a single heat-shock of rBCG was maintained longer than 3 weeks. Immunoblot experiments with intact rBCG did not show any distinctive positive signal, suggesting that the recombinant protein was not secreted or exposed at the surface of BCG. The guinea pigs immunized with live rBCG showed delayed type hypersensitivity (DTH) by the systemic area as well as an effective humoral immunity, suggesting that tbis rBCG is believed to elicit eKcient immune responses against p24, even though the expression is restricted only in the cytoplasm as reported previously with other antigen. These results demonstrate that BCG can be developed as a live recombinant vaccine vector against a broad spectrum of infectious disease.
Animals* ; Blotting, Western ; Clone Cells ; Cloning, Organism ; Communicable Diseases ; Cytoplasm ; Guinea Pigs ; HIV* ; HIV-1 ; Hypersensitivity ; Immunity, Humoral ; Mycobacterium bovis* ; Replication Origin

OBJECTIVE: This study aimed to test the possible association between Cholecystokinin B receptor (CCKBR) promoter gene and panic disorder. METHODS: 262 patients with panic disorder and 76 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-based method. RESULTS: Allele distribution of CT repeat polymorphism in patients with panic disorder was not different from those of the controls. However, after excluding the patients with panic disorder comorbid with major depressive disorder and other anxiety disorder, we found out the significant association of CCKBR (CT)n repeat with the panic disorder without comorbidities. And we analysed the data as a di-allelic polymorphism with a short (140-162 bp) and a long (164-180 bp) allele. In the di-allelic analysis, there was an excess of the shorter allele in patients with panic disorder. CONCLUSION: The present study suggested that the CCKBR promoter dinucleotide polymorphism may have a potential role for susceptibility to panic disorder in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.
Alleles ; Anxiety Disorders ; Cholecystokinin* ; Comorbidity ; Depressive Disorder, Major ; Diagnosis* ; Drug Therapy* ; Humans ; Panic Disorder* ; Panic* ; Receptor, Cholecystokinin B*

BACKGROUND: Impetigo is mostly caused by either Staphylococcus aureus(S. aureus) or group A beta-hemolytic Streptococcus(Streptococcus pyogenes). As the relative preponderance of each microorganism varies greatly, so reports have been contradictory. Recently, S. aureus has been reported as the principal causative microorganism of impetigo and shown variable degrees of antimicrobial resistance. OBJECTIVE: The purpose of this study is to find out the main causative microorganism and the antibiotic susceptibility of causative organism in impetigo. METHOD: Bacterial cultures and antimicrobial susceptibility test were done in 55 patients with impetigo. RESULTS: S. aureus was cultured from 49 patients of 55 patients(89.1%), and the remains were coagulase negative Staphylococcus, Streptococcus, Citrobacter braakii and Klebsiella. The resistant rates of S. aureus against antibiotics were as follows ; penicillin: 98.0%, gentamicin: 69.2%, tobramycin: 65.0%, tetracycline: 62.5%, erythromycin: 57.1%, piperacillin: 36.0%, clindamycin: 17.4%, cefazolin: 9.5%, ciprofloxacin: 8.1%, imipenem: 5.0%, oxacillin: 3.9%, trimethoprim-sulfamethoxazole: 3.7%, cefuroxime: 0%, nobobiocin: 0%, teicoplanin: 0%, and vancomycin: 0%. Methicillin-resistant S. aureus(MRSA) and oxacillin-resistant S. aureus(ORSA) were cultured in three of 20 patients(15%) and one of 26 patients(3.9%), respectively. The resistant rates of MRSA or ORSA against other antibiotics were as follows ; cefazolin, ciprofloxacin, erythromycin, and penicillin: 100%, tobramycin: 67%, trimethoprim-sulfamethoxazole: 25%, and teicoplanin, vancomycin, and nobobiocin: 0%. CONCLUSION: S. aureus was the most prominent pathogen in impetigo in this study and sensitive to cefuroxime, nobobiocin, teicoplanin, vancomycin and oxacillin, but not to penicillin, gentamicin, tobramycin, tetracycline and erythromycin. The effective antibiotics in the treatment of MRSA or ORSA were vancomycin, nobobiocin, teicoplanin and trimethoprim-sulfamethoxazole.
Anti-Bacterial Agents ; Cefazolin ; Cefuroxime ; Ciprofloxacin ; Citrobacter ; Clindamycin ; Coagulase ; Erythromycin ; Gentamicins ; Humans ; Imipenem ; Impetigo* ; Klebsiella ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus ; Oxacillin ; Penicillins ; Piperacillin ; Staphylococcus ; Staphylococcus aureus ; Streptococcus ; Teicoplanin ; Tetracycline ; Tobramycin ; Trimethoprim, Sulfamethoxazole Drug Combination ; Vancomycin