Background: Rheumatoid arthritis is non chronic imflammatory disease which affects joint synoval membrane and cartilaginous tissue was become as a destruction. We studied shinar-8 compound prescription was the background of our research work which is was less poisonous, with plant origin we formed joint inflammatory model which was stimulated collagen in experimental animal.Purpose: We aimed at studying action against compound prescription inflammation of shinar-8 by forming RA pathological model which was stimulated by collagen in experimental white mouse.Methods and materials: Methodology in our study divided 60 laboratory white mouse into 3 groups (control, comparing and treatment). We did clinical, laboratory and histological analyses on 14, 28, 42 days.Result: Result of determing virulence of shinar 8 compounding prescription, seeing from the result of experience 50% of death forming dosage of liquid tincture prepared wich 1:10 proportion is (LD50) 10,34g/kg. In the process of experiment when we defined leukocytosis change in the blood it revealed in 100% of control group of mice, in 55% of comparing group and in 41% of treatment group. In histological analyse of mouse joint which shinar 8 was used on 14 and 18 days inflammation symptoms disappeared but pannus and erosion still exist, in control group. In histological analyse which was made on the 42 days space between joint was clean, erosion disappeared regeneration of chondrocyte cells improved, nucleus was enlarged, hyperplasia symptoms revealed clearly.Conclusions:1. Virulence of shinar 8 compound prescription was 10,34 g/kg less.2. When we formed RA pathologic model symptom of forming pannus in cartiligous tissie (by histological analyse) it become erosion and serous hyperplasia.3. In the experimental animals which shinar-8 prescription was used symptom of leukocytosis revealed in 41%, on the 35 day symptom of inflammation disappeared and regeneration of chondrocyte cell improved.

Background: Rheumatoid arthritis is a chronic inflammatory disease that leads to the destruction of articular cartilage and ankylosis of the joints. Traditional drug Shinar-8 is made from 8 components including Glycyrrhiza uralensis Fisch., Tribulus terrestric, Iris tenuifolia, Thlaspi arvense, Ribes diacanthum Pall., Ephedra Przewalskii Stapf., Rosa acicularis Lindl., and Cynara scolymus L. Objectives: The effect of Shinar-8 on mice rheumatoid arthritis model induced by collagen was examined. Methods and Materials: Laboratory tests and histopathological analysis were carried out 35, 49, and 63 days after collagen injection or 14, 28, and 42 days after Shinar-8 treatment. Results and conclusions: LD50 of Shinar-8 was found to be 10.34g/kg. This was 41.36 fold higher than the treatment dose of Shinar-8. Leukocytosis in peripheral blood was reduced by Shinar-8 (41%). On 14 and 28 days after Shinar-8 treatment signs of inflammation were disappeared although pannus and erosion remained. Normal joint spaces, clear articular surface, proliferation of chondrocytes, and hyperplasia were observed by histological analysis after 42 days of Shinar-8 treatment. Shinar- 8 may have anti-inflammatory effects on collagen-induced arthritis in mice.