Background: Premature ejaculation is one of the most common sexual dysfunction which affects the quality of life in both men and women. Objectives: To assess the effects of a topical anesthetic mixture in the treatment of Premature Ejaculation (PE). Subjects and method: Fifty-six men diagnosed as PE were guided to use a local anesthetic mixture of procaine-xylocain applied to glands on the penis before sexual activity (about 15 minutes prior), the course of treatment lasted 3 months. Results:There was a significant increase in the mean of intravaginal ejaculatory latency time (IEL n from 1.87 to 8.41 mins (p<0. OS) and satisfying scores of both overall sex life and sexual relationship with their partners. General results were divided into 4 degrees: good (30.2%) average (43.4%) no result (15.1%) and negative results (11.3%). Some side effects included retarded ejaculation or anejacualation (9.43%) decrease of glands penis and vagina sensitivity (28.3% and 9.43% respectively). Conclusion: While there is no effective therapy for PE, anesthetic creams might be effective for treatment of the disorder. \r\n', u'\r\n', u'
topical anesthetic mixture ; premature ejaculation

Purpose: This study aimed to determine the occurrence rate of gestational trophoblastic neoplasia (GTN) and its related factors in aged women with hydatidiform mole (HM) in Tu Du Hospital, Vietnam. Materials and Methods: This retrospective cohort study included 372 women aged ≥40 years with HM diagnosed through postabortion histopathological assessment in Tu Du Hospital from January 2016 to March 2019. Survival analysis was used for GTN cumulative rate estimation, log-rank test for group comparison, and Cox regression model for determining GTN-related factors. Results: After a 2-year follow-up, 123 patients were found to have GTN at a rate of 33.06% [95% confidence interval (CI): 28.30– 38.10]. GTN occurrence meant that the time was 4.15±2.93 weeks with peaks at week 2 and 3 after curettage abortion. The GTN rate was remarkably higher in the ≥46-year age group than in the 40-to-45-year age group [hazard ratio (HR)=1.63; 95%CI: 1.09– 2.44], as was the vaginal bleeding group compared to the non-bleeding group (HR=1.85; 95%CI: 1.16–2.96). Preventive hysterectomy and preventive chemotherapy plus hysterectomy in the intervention group reduced the GTN risk compared to the no intervention group at HRs of 0.16 (95%CI: 0.09–0.30) and 0.09 (95%CI: 0.04–0.21), respectively. Chemoprophylaxis failed to decrease the GTN risk when comparing the two groups. Conclusion Post-molar pregnancy GTN rate in aged patients was 33.06%, much higher than that of the general population. Preventive hysterectomy or chemoprophylaxis plus hysterectomy are effective treatment methods to support GTN risk reduction.