The vas deferens is a site which can be exploited for male contraception without undue side effects. The only ef fective technique available for male contraception is vasectomy, being practiced world wide, despite that it is a perma nent surgical procedure and its successful reversal is not assured. Although no-scalpel vasectomy minimizes surgical procedures, the fate of its reversal is akin to that of vasectomy. Several occlusive and non-occlusive vasalprocedures which claim to be reversible without surgical intervention, possess more disadvantages than advantages. Vas occlusion with plug, ‘ Shug' or medical grade silicone rubber, although claimed to produce reversible azoospermia without affect ing spermatogenesis, requires skilled microsurgery for their implantation and later removal. RISUGR, a non-sclerotic polymer styrene maleic anhydride (SMA), could be more advantageous than vasectomy and other vas occlusive proce dures in that it could be a totally non-invasive procedure by "no-scalpel injection" and "non-invasive reversal". It is claimed to offer long-term contraception without adverse side effects and also to be possible as a male spacing method by repeated vas occlusion and non-invasive reversal. The drag is currently under multicentre Phase 1II clinical trial.