BACKGROUNDPhysical, mental and gross motor development occur intensively during the childhood. Therefore it is important to detect any developmental delays early in order to take proper intervention which is significant for mental ability and personal development of a child. In this study, we aimed to evaluate mental and gross motor development of the kindergarten’s children in Bayanzurkh and Khan-Uul district.METHODSWe selected 157 children, aged from 3 to 6 years, from Bayanzurh district’s kindergarten and 125 children from Khan-Uul district’s kindergarten randomly. Population basedcross sectional study design was used. Mental and gross motor development was measured by Denver-II test. Statistical analysis of the collected data was conducted using SPSS 17.0 software program.RESULTSLanguage development delay, fine motor-adaptive development delay, gross motor development delay and personal-social development delay were observed in 42%, 15%, 12%, 8% of the kindergarten children, respectively.CONCLUSIONSWe conclude that it is imperative to pay more attention to mental, language and gross motor developments of children in kindergarten.

We present the fi rst 2 cases of cochlear implantation in Mongolia using “SONATA” type implant of “MED-EL” Company, Austria. CASE 1: A six years old, female had been diagnosed with bilateral congenital profound hearing loss and had been fi tted with hearing aids for 5 years and received little benefi t from her hearing aids and developed very poor speech and language, used lip reading and have had vocabulary of approximately 10 words. A radiological evaluation showed normal cochlea and auditory nerve. Cochlear implant team including speech therapists and audiologists based on the informed consent of patient’s parent decided that family able to participate in follow-up, speech habilitation programme. Patient implanted with SONATA of MED-EL on 4 August, 2009. Electrodes were inserted fully. After 10 days of switch on of the speech processor the patient showed signs of initial hearing of loud sounds. After 5 months of Auditory Verbal Therapy the vocabulary increased up to 50 words. Hearing, cognition and responses are increasing simultaneously. CASE 2: A 2 years old female. Congenitally deaf in both ears. Fitted with hearing aid for 3 months before the surgery and there was no benefi t from hearing aid. Physically and mentally healthy. Patient implanted with SONATA of MED-EL on 4 August, 2009. Electrodes were inserted fully. On 25th days of switching on of speech processor the patient showed initial hearing of loud sounds. Currently, after 5months of treatment her vocabulary is 2 short words and can recognize 4 syllabeles. She is very active, repeats actions and has open nature, feels comfortable with CI.

: In enterohepatic recycling, foreign chemicals entering the alimentary tract and gut normal micro flora (ShagjJambal., 1989) are absorbed into portal venous blood by enterocytes, removed from blood by uptake into hepatocytes, secreted into the bile, and then deposited back into the intestinal lumen where they may be reabsorbed by intestinal wall cells and available for recycling (compartment model modified by Wang and Reuning). This process is called enterohepatic circulation or enterohepatic recycling (Rollins and Klaasen, 1979). Some studies have attempted to interrupt the enterohepatic recycling of toxicants such as pesticides and heavy metals and 56 carbon tetrachloride (CCl₄). Plant Material The plant Gentiana macrophylla pall. Was collected during july 2017 from the forest region Galt sum, Khuvsgul aimakh, Mongolian. The taxonomical identification of the plant was done by Botanical survey of Ganbold E. (ScD) Mongolian university subsidiary of Ulanbator institute, Ulanbator. The study was based on the New medicine medical university bio-model, pharmacology laboratory and laboratory. ELISA-biochemistry laboratory. Animals: Male C57BL/6 (miceweight 18-22g (n=40)) were obtained from the Mongolian national university of Medical sciences animal house. Experimental procuders were conducted in accordance with the regulations of Animal Ethical committee. Myeloperoxidase (MPO) activity was measured according to the technique described by Krawisz et al. (1984) . Assay for lipid peroxides in animal tissues by thiobarbituric acid Reaction (Yagi, K. and Ohkova.,1979). A significant decrease (P<0.005) in the MDA was observed in the Gentiana macrophylla(GM) treated group (0.340±0.031)when compared with the control group (0.521±0.023). Conclusion The results of the study show that Gentiana macrophylla is inhibition of lipid peroxidation, protection of liver cell. From the protonation compounds generate polyphenol compound with rich hydroxyl and alkaloid. These compounds help to lipid peroxidation or antioxidation and membrane protection.The results of the study show that Gentiana macrophylla is inhibition off oxidation ferric molecule in vitro reaction and detoxification of reactive oxygen species release from damaged liver cell by CCL₄.