The development of metal complexes has inspired researchers to progress in this domain due to their extensive applications in the biological field. Regarding the application, binuclear metal complexes are less explored than their mononuclear counterparts. Recent development in transition metal Schiff base complexes was outlined and presented in detail with their respective vast applications, especially antibacterial. The relationship of their structure, functions, properties, and key elements that affected antibacterial activities was demonstrated. This review was aimed to present the latest advancement of numerous lower and higher transition metal complexes, especially mononuclear ones. Moreover, their various properties are highlighted for future work related to binuclear Schiff base metal complexes and to persuade future research in this exciting field.