Background: Various food quality indicators have been proposed as tools for predicting metabolic syndrome (MetS). This study investigated the association between global diet quality score (GDQS) and the risks of developing MetS and its components. Methods: In this secondary analysis, we included elective adult participants (n=4,548) from the Tehran Lipid and Glucose Study. Dietary data were collected by a valid and reliable semi-quantitative food frequency questionnaire. MetS was defined according to the Iranian modified National Cholesterol Education Program. Multivariable Cox proportional hazard regression models were used to estimate the incidence of MetS in association with GDQS. Results: This study involved 1,762 men and 2,786 women with a mean±standard deviation age of 38.6±14.3 and 35.9±11.8 years, respectively. A total of 1,279 subjects developed MetS during the mean follow-up of 6.23 years. Incidence of MetS was associated with GDQS (hazard ratio [HR], 1.00; 0.90 [95% confidence interval, CI, 0.82 to 0.98]; 0.84 [95% CI, 0.76 to 0.91]; 0.80 [95% CI, 0.73 to 0.89]; P for trend <0.001) after adjusting for confounding variables. The healthy food group component of GDQS was related to MetS incidence. GDQS in the range of 12%–17% in the fourth quartile was associated with a decrease in incidence of MetS components. Both healthy and unhealthy food group components of the GDQS decreased the incidence of high triglycerides, high blood pressure, and high fasting blood glucose. Conclusion Higher GDQS was associated with a lower risk of the incidence of MetS or its components among Tehranian adults. Higher intake of healthy food group components and lower consumption of unhealthy food group components of the GDQS predicted lower MetS incidence and risk factors.

Background: Various food quality indicators have been proposed as tools for predicting metabolic syndrome (MetS). This study investigated the association between global diet quality score (GDQS) and the risks of developing MetS and its components. Methods: In this secondary analysis, we included elective adult participants (n=4,548) from the Tehran Lipid and Glucose Study. Dietary data were collected by a valid and reliable semi-quantitative food frequency questionnaire. MetS was defined according to the Iranian modified National Cholesterol Education Program. Multivariable Cox proportional hazard regression models were used to estimate the incidence of MetS in association with GDQS. Results: This study involved 1,762 men and 2,786 women with a mean±standard deviation age of 38.6±14.3 and 35.9±11.8 years, respectively. A total of 1,279 subjects developed MetS during the mean follow-up of 6.23 years. Incidence of MetS was associated with GDQS (hazard ratio [HR], 1.00; 0.90 [95% confidence interval, CI, 0.82 to 0.98]; 0.84 [95% CI, 0.76 to 0.91]; 0.80 [95% CI, 0.73 to 0.89]; P for trend <0.001) after adjusting for confounding variables. The healthy food group component of GDQS was related to MetS incidence. GDQS in the range of 12%–17% in the fourth quartile was associated with a decrease in incidence of MetS components. Both healthy and unhealthy food group components of the GDQS decreased the incidence of high triglycerides, high blood pressure, and high fasting blood glucose. Conclusion Higher GDQS was associated with a lower risk of the incidence of MetS or its components among Tehranian adults. Higher intake of healthy food group components and lower consumption of unhealthy food group components of the GDQS predicted lower MetS incidence and risk factors.

Background: Various food quality indicators have been proposed as tools for predicting metabolic syndrome (MetS). This study investigated the association between global diet quality score (GDQS) and the risks of developing MetS and its components. Methods: In this secondary analysis, we included elective adult participants (n=4,548) from the Tehran Lipid and Glucose Study. Dietary data were collected by a valid and reliable semi-quantitative food frequency questionnaire. MetS was defined according to the Iranian modified National Cholesterol Education Program. Multivariable Cox proportional hazard regression models were used to estimate the incidence of MetS in association with GDQS. Results: This study involved 1,762 men and 2,786 women with a mean±standard deviation age of 38.6±14.3 and 35.9±11.8 years, respectively. A total of 1,279 subjects developed MetS during the mean follow-up of 6.23 years. Incidence of MetS was associated with GDQS (hazard ratio [HR], 1.00; 0.90 [95% confidence interval, CI, 0.82 to 0.98]; 0.84 [95% CI, 0.76 to 0.91]; 0.80 [95% CI, 0.73 to 0.89]; P for trend <0.001) after adjusting for confounding variables. The healthy food group component of GDQS was related to MetS incidence. GDQS in the range of 12%–17% in the fourth quartile was associated with a decrease in incidence of MetS components. Both healthy and unhealthy food group components of the GDQS decreased the incidence of high triglycerides, high blood pressure, and high fasting blood glucose. Conclusion Higher GDQS was associated with a lower risk of the incidence of MetS or its components among Tehranian adults. Higher intake of healthy food group components and lower consumption of unhealthy food group components of the GDQS predicted lower MetS incidence and risk factors.

Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in greencoffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levelsin women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients withPCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n = 22) received 400 mg of green coffee supplements, while the control group (n = 22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p = 0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p = 0.013) and triglyceride levels by 6.1 units (p = 0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-densitylipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.

Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in greencoffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levelsin women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients withPCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n = 22) received 400 mg of green coffee supplements, while the control group (n = 22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p = 0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p = 0.013) and triglyceride levels by 6.1 units (p = 0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-densitylipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.

Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in greencoffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levelsin women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients withPCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n = 22) received 400 mg of green coffee supplements, while the control group (n = 22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p = 0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p = 0.013) and triglyceride levels by 6.1 units (p = 0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-densitylipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.

Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in greencoffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levelsin women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients withPCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n = 22) received 400 mg of green coffee supplements, while the control group (n = 22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p = 0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p = 0.013) and triglyceride levels by 6.1 units (p = 0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-densitylipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.

Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in greencoffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levelsin women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients withPCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n = 22) received 400 mg of green coffee supplements, while the control group (n = 22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p = 0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p = 0.013) and triglyceride levels by 6.1 units (p = 0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-densitylipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.