Introduction: This study investigated the effect of combined plant-based protein supplementation and resistance training on muscular strength, blood markers of protein catabolism, immune function, and bone metabolism in sedentary adult males. Methods: In this randomised, double-blinded study, 28 healthy males aged 19 – 29 years old were equally assigned into four groups: a combined plant-based protein with resistance training (PBPEX), plant-based protein alone (PBP), resistance training alone (EX) and control (C). Mode of resistance training was flat barbell press, machine shoulder press, wide grip lateral pull-down, seated cable row, barbell back squat, leg press and leg extension. The 8-week resistance training involved three sets of 60-70% of one-repetition maximum (1-RM) at 4-6 repetition/set/mode per session, three sessions/week. Participants in PBPEX and PBP groups consumed a plant-based protein supplement consisted of 9.8 g soy and pea protein for seven days/week. Results: PBPEX showed significant increases (p<0.01) in the knee and shoulder flexion peak torque compared to EX groups, respectively. PBP showed a significantly higher level (p<0.05) of serum urea, and blood urea nitrogen (BUN) compared to other groups. There were no changes in immune function and bone metabolism markers between pre- and post-exercise in all groups. Conclusions: These findings implied that a combination of plant-based protein supplementation and resistance training elicited greater beneficial effects on muscular strength than resistance training alone and plant-based protein supplementation alone. Therefore, combined plant-based protein with resistance training may be recommended in planning exercise and nutritional programme for sedentary male adults.