Objective? To explore the application effects of nurse-patient co-management intervention in arrhythmia patients with intravenous amiodarone. Methods? From October 2015 to September 2017, we selected 126 arrhythmia patients with amiodarone of the First Affiliated Hospital of Xinjiang Medical University as subjects by convenience sampling. All of the subjects were randomly divided into intervention group and control group, 63 cases in each group. Control group adopted routine nursing, while intervention group carried out nurse-patient co-management intervention. We compared the differences in the incidence of phlebitis, blood pressure, heart rate, adverse reactions, hospital stay and satisfaction of patients both groups. Results? The incidence of phlebitis and its cumulative occurrence time of intervention group were lower than those of control group (P＜ 0.05);the level of blood pressure after using medication of patients in intervention group was higher than that in control group, and incidence of gastrointestinal adverse reaction and hospital stay of patients in intervention group were less than those in control group (P＜0.05). Satisfaction with nursing of intervention group was higher than that of control group (P＜0.05). Conclusions? Nurse-patient co-management intervention can increase the safety of arrhythmia patients with amiodarone, reduce the incidence of adverse reactions and improve patient satisfaction which is worthy of being widely used in clinical application.