Background & Objective: It is well established that the effectiveness of vagus nerve stimulation (VNS) therapy increases over 2-3 years. When increasing the dose of VNS, some patients were noted to respond even at low-dose stimulation in the first few months. The purpose of this study was to evaluate the relationship between an initial response to VNS and long-term response in a retrospective study of patients with intractable epilepsy. Method: We retrospectively analysed 56 patients who had VNS implantation in our centre. All patients had undergone complete presurgical evaluation. After implantation, the patients were examined at regular intervals of one month for 6-9 months and then followed up regularly for more than 2 years. Their seizure frequency and intensity were documented in their seizure logs. Results: Six patients achieved Engel class I (11%) seizure outcome, 16 achieved Engel class II (28%), and 19 achieved Engel class III (34%). Of the 22 patients with Engel I and II, the 19 in Engel class I (100%) and II (81%) showed an initial response within 6 months, an earlyonset response of VNS implantation. Conclusions: Early-onset response could be an independent predictor for achievement of Engel class I and II in long-term follow-up. Keyword: Background & Objective: It is well established that the effectiveness of vagus nerve stimulation (VNS) therapy increases over 2-3 years. When increasing the dose of VNS, some patients were noted to respond even at low-dose stimulation in the first few months. The purpose of this study was to evaluate the relationship between an initial response to VNS and long-term response in a retrospective study of patients with intractable epilepsy. Method: We retrospectively analysed 56 patients who had VNS implantation in our centre. All patients had undergone complete presurgical evaluation. After implantation, the patients were examined at regular intervals of one month for 6-9 months and then followed up regularly for more than 2 years. Their seizure frequency and intensity were documented in their seizure logs. Results: Six patients achieved Engel class I (11%) seizure outcome, 16 achieved Engel class II (28%), and 19 achieved Engel class III (34%). Of the 22 patients with Engel I and II, the 19 in Engel class I (100%) and II (81%) showed an initial response within 6 months, an earlyonset response of VNS implantation. Conclusions: Early-onset response could be an independent predictor for achievement of Engel class I and II in long-term follow-up. Keyword: Vagus nerve stimulation, long term outcome, early onset response, predictor, epilepsy

We report a childhood case of localization-related epilepsy manifesting frequent gelastic seizures, which were successfully treated with topiramate (TPM) monotherapy. The seizures were not associated with feelings of mirth. High-resolution three-tesla magnetic resonance imaging revealed no structural abnormality. Interictal 18F-fluorodeoxyglucose positron emission tomography showed hypometabolism over the entire right hemisphere. Single-photon emission computed tomography imaging, both ictal and interictal, demonstrated no significant findings. Interictal electroencephalography (EEG) showed paroxysms in the right frontal region. Ictal video EEG demonstrated diffuse attenuation, followed by fast activities and spike-wave complexes predominantly over the right hemisphere. At the ictal EEG onset, low amplitude paroxysmal fast activity was recorded over the F8-T4 region. The seizures were considered to have originated from the right frontal lobe. TPM monotherapy resulted in complete cessation of the seizure. We suggest that TPM should be considered as a valuable tool for treating childhood intractable gelastic seizures, which are not due to hypothalamic hamartoma.

Introduction: To evaluate the utility of vagus nerve stimulation (VNS) therapy for patients with intractable postencephalitic epilepsy in the reduction of seizure frequency and quality of life (QOL). Methods: We studied five patients with intractable postencephalitic epilepsy, the age ranged from 21 to 46 years. QOL of the patients was evaluated with the questionnaire, QOLIE-31-P. Results: VNS therapy improved seizure frequency in four patients (80%). One patient (20%) had no reduction of seizure frequency. Three patients had improvements in QOLIE-31-P (p < 0.024) and became socially independent. Two other patients continued to be dependent, and have lesser degree of improvements in their QOLIE-31-P scores.Conclusion: VNS is effective for patients with intractable postencephalitic epilepsy and is able to improve the QOL.