1.Perturbation of Secretory Ig A in Saliva and Its Daily Variation by Academic Stress
Zhong-Qiu GUO ; Takemi OTSUKI ; Yasuhisa ISHII ; Aya INAGAKI ; Youichiro KAWAKAMI ; Yuki HISANO ; Riichiro YAMASHITA ; Kenta WANI ; Haruko SAKAGUCHI ; Satoshi TSUJITA ; Kanehisa MORIMOTO ; Ayako UEKI
Environmental Health and Preventive Medicine 2001;6(4):268-272
Objectives: Several studies have reported that the secretory immunoglobulin A (S-IgA) concentration in saliva is an indicator of psychological stress. The aim of this study was to clarify the relationship between S-IgA and the stress from academic examinations. Methods: S-IgA levels in 10 medical student volunteers from the second year course between May 4 and July 13, 2000 were examined using the ELISA method. Results: There was a tendency for S-IgA in saliva to be higher on the day before academic examinations and during them, and lower on the days between these examinations. Conclusions: It may be possible to use this measurement to monitor psychological stress in students and workers.
Upper case ess
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Immunoglobulin A measurement
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Saliva
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Stress bismuth subsalicylate
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Daily
2.Detection of anti-topoisomerase I autoantibody in patients with silicosis.
Akiko TOMOKUNI ; Takemi OTSUKI ; Haruko SAKAGUCHI ; Yumika ISOZAKI ; Fuminori HYODOH ; Masayasu KUSAKA ; Ayako UEKI
Environmental Health and Preventive Medicine 2002;7(1):7-10
OBJECTIVESThe aim of this study was to detect anti-topoisomerase I (anti-topo I) autoantibodies, which are known to be limited in systemic sclerosis patients, in silicosis patients with no clinical symptoms of autoimmune disease.
METHODSSerum anti-topo I autoantibodies were detected using ELISA. Differences in clinical parameters between patients with and without anti-topo I autoantibodies were analyzed.
RESULTSSeven of 69 patients had anti-topo I autoantibodies. These 7 patients showed elevated PaCO(2) values (P=0.0212), and inverse correlations between serum soluble Fas levels and PaCO(2) values were found.
CONCLUSIONAnti-topo I autoantibodies were detected in 10.1% of silicosis patients without any clinical symptoms of autoimmune disease. The findings here suggest that the genesis of anti-topo I autoantibodies might be related to pulmonary involvement or lung fibrosis associated with progression of silicosis.
3.Perturbation of secretory Ig A in saliva and its daily variation by academic stress.
Zhong-Qiu GUO ; Takemi OTSUKI ; Yasuhisa ISHI ; Aya INAGAKI ; Youichiro KAWAKAMI ; Yuki HISANO ; Riichiro YAMASHITA ; Kenta WANI ; Haruko SAKAGUCHI ; Satoshi TSUJITA ; Kaneshisa MORIMOTO ; Ayako UEKI
Environmental Health and Preventive Medicine 2002;6(4):268-272
OBJECTIVESSeveral studies have reported that the secretory immunoglobulin A (S-IgA) concentration in saliva is an indicator of psychological stress. The aim of this study was to clarify the relationship between S-IgA and the stress from academic examinations.
METHODSS-IgA levels in 10 medical student volunteers from the second year course between May 4 and July 13, 2000 were examined using the ELISA method.
RESULTSThere was a tendency for S-IgA in saliva to be higher on the day before academic examinations and during them, and lower on the days between these examinations.
CONCLUSIONSIt may be possible to use this measurement to monitor psychological stress in students and workers.
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