1.Advance in pathogenesis of oligodendrocytes-associated autism spectrum disorder.
Chinese Journal of Preventive Medicine 2022;56(9):1232-1237
Autism spectrum disorder (ASD) is a serious neurodevelopmental impairment of children. Because of its difficulty of early diagnosis, length of disease course, irreversible injury and slim chance of curability, it brings heavy burdens to patients, their families and the whole society. Recent studies have shown that the pathogenic mechanism of ASD is closely related to the abnormal myelination caused by the imbalance of differentiation, proliferation and apoptosis of oligodendroglial lineage cells. This article will review on the role of oligodendroglial lineage cells in myelination and the mechanisms of ASD caused by improper differentiation, proliferation and apoptosis of oligodendroglial lineage cells, according to advanced researches. Oligodendrocytes play vital roles in neurodevelopment, and the defect in these cells has been recognized as one of the key pathogenic mechanisms leading to ASD. Elucidating the effects and disciplines which oligodendrocytes exert on the occurrence and development of ASD would provide guidance for precise prevention and control of neurodevelopmental disorders such as ASD.
Autism Spectrum Disorder/epidemiology*
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Cell Differentiation
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Humans
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Oligodendroglia
2.Shanghai Autism Early Development: An Integrative Chinese ASD Cohort.
Yuan DAI ; Yuqi LIU ; Lingli ZHANG ; Tai REN ; Hui WANG ; Juehua YU ; Xin LIU ; Zilin CHEN ; Lin DENG ; Minyi TAO ; Hangyu TAN ; Chu-Chung HUANG ; Jiaying ZHANG ; Qiang LUO ; Jianfeng FENG ; Miao CAO ; Fei LI
Neuroscience Bulletin 2022;38(12):1603-1607
3.Does Periconceptional Fish Consumption by Parents Affect the Incidence of Autism Spectrum Disorder and Intelligence Deficiency? A Case-control Study in Tianjin, China.
Lei GAO ; Shan Shan CUI ; Yu HAN ; Wei DAI ; Yuan Yuan SU ; Xin ZHANG
Biomedical and Environmental Sciences 2016;29(12):885-892
OBJECTIVEThis study aimed to explore the association between periconceptional fish consumption by parents and autism spectrum disorder (ASD) and intelligence deficiency (ID).
METHODSA case-control study was conducted through a questionnaire with 108 ASD cases, 79 ID cases, and 108 controls. The ASD and ID cases were students from special educational schools in Tianjin from 2012 to 2014. The age- and sex-matched controls were from a high school, three primary schools, and a kindergarten in Tianjin. Multivariate logistic regression was performed.
RESULTSPaternal habit of eating hairtail before fertilization, maternal preference for fruits during pregnancy, and maternal habit of eating grass carp during pregnancy were preventive factors for ASD. Paternal habit of drinking alcohol before fertilization was a risk factor for ID, whereas maternal preference for fruits during pregnancy and maternal habit of eating crucian carp during pregnancy were protective factors for ID.
CONCLUSIONParental fish consumption is beneficial for the prevention of ASD and ID. Meanwhile, the protective effects of fish consumption on ASD and ID differ. More attention should be paid to the combined effect of other food when eating fish.
Adolescent ; Animals ; Autism Spectrum Disorder ; epidemiology ; etiology ; Case-Control Studies ; Child ; Child, Preschool ; China ; epidemiology ; Diet ; adverse effects ; Environmental Exposure ; Female ; Fishes ; Humans ; Incidence ; Intellectual Disability ; epidemiology ; etiology ; Male ; Maternal Exposure ; Paternal Exposure ; Pregnancy ; Prenatal Exposure Delayed Effects ; epidemiology ; etiology ; Risk Factors ; Species Specificity