2.The effects of oophorectomy and hysterectomy on rat spine and tibia.
Soo Hyun CHO ; Jung Kwon CUNG ; Kyung Tai KIM ; Sam Hyun CHO ; Jai Auk LEE
Korean Journal of Obstetrics and Gynecology 1993;36(11):3784-3791
No abstract available.
Animals
;
Female
;
Hysterectomy*
;
Ovariectomy*
;
Rats*
;
Spine*
;
Tibia*
3.A case of pregnancy complicated primary hypothyroidism presenting with cardiac tamonade resulted from massive pericardial effusion and megacolon.
Ki Heon LEE ; Jung Bae YOO ; Kyung Tai KIM ; Youn Yeoung HWANG ; Jai Auk LEE
Korean Journal of Perinatology 1993;4(3):433-440
No abstract available.
Hypothyroidism*
;
Megacolon*
;
Pericardial Effusion*
;
Pregnancy*
4.Epithelial ovarian cancer:comparison of serous and mucinous cystadenocarcinoma.
Dae Woon KIM ; Ki Hun LEE ; Jung Hwan SHIN ; Kyung Tai KIM ; Youn Yeoung HWANG ; Hyung MOON ; Jai Auk LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2706-2714
No abstract available.
Cystadenocarcinoma, Mucinous*
;
Mucins*
5.Three Cases of Repeated Mole.
Yoon Young LEE ; Young Oh KIM ; Jung Bae YOO ; Kyung Tai KIM ; youn Yeoung HWANG ; Hyung MOON ; Jai Auk LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(2):96-101
Three patients(1%) with recurrent molar pregnancy were managed arnong 317 registered molar pregnancies at the department of Obstetrics and Gynecology, Hanyang University Hospital between 197S and 1991. Reeurrent molar pregnancy seemed to be oaiated with a worsening histology and an increased incidence of proliferative trophoblastic sequelae in the successive episodes of hydatidiform mole. The treatment of recurrent mole is discussed and the literature regardmg recurrent rnolar pregnancy is reviewed.
Female
;
Gynecology
;
Hydatidiform Mole
;
Incidence
;
Obstetrics
;
Pregnancy
;
Trophoblasts
6.Analysis of anatomic causes of recurrent spontaneous abortion.
Kwang Jin KIM ; Ki Hun LEE ; Moon Il PARK ; Sung Ro CHUNG ; Jai Auk LEE ; Hyung MOON ; Doo Sang KIM
Korean Journal of Obstetrics and Gynecology 1992;35(2):220-228
No abstract available.
Abortion, Spontaneous*
;
Female
;
Humans
;
Pregnancy
7.Accuracy of Cervical Pap Smear.
Sam Hyun CHO ; Seung Ryong KIM ; Hyang MOON ; Jai Auk LEE ; Youn Yeoung HWANG ; Kyung Tal KIM ; Seung Hee GOH
Korean Journal of Gynecologic Oncology and Colposcopy 1999;10(2):156-163
BACKGROUND: Carcinoma of the uterine cervix is a theoretically preventable disease because its precursor lesions can be detected by cervical Papanicolau smears and appropriately treated, Although cervical cytology screening programmes have resulted in the redution of cervical cancer incidence and mortality, Pap smear have been subjected to intense scrutiny and criticism in recent years. The focus of criticism has been the false-negative Pap smear, and the false-negative Pap smear is the major quality issue currently facing the physicians. To reduce the false-negative rate of Pap smear, it is essential to improve the accuracy of Pap smear. But false-negative rate of Pap smear has been reported variously. OBJECTIVE: This study was undertaken to evaluate accuracy of Pap smear by study false-negative and false-positive rate of Pap smear and to determine whether false-negative and false-positive rate had any correlations with clinical factors. STUDY DESIGN: The study population was comprised of 346 women, who were undertaken gynecologic operation at the Department of Obstetrics & Gynecology at Hanyang University hospital between March, 1997 and April, 1998. All patients were taken Pap smear before operation. In 93 women of these, preoperative diagnosis were cervical intraepithelial neoplasia and carcinoma in situ of uterine cervix, and in 253 women of these, preoperative diagnosis were benign disease as uterine myoma or adenomyosis, etc. All of their surgical specimen were examined. Pap smear, pathology, medical charts of all patients were reviewed retrospectively, and false-negative rate and false-positive rate were calculated. Clinical factors that associated with false-negative and false-positive rate were evaluated. Fishers exact test and Pearson chi-square test were used of statistical analysis, RESULTS: False-negative rate of Pap smear was 7.2%, false-positive rate was 4.6%, corresponding rate with histology was 88.2%. Sensitivity and specificity of PAP smear were 87.0% and 97.0% respctively. According to gross finding of uterine cervix, erosion was 46.6% in cervical intraepithelial neoplasia, 67.8% in carcinoma in situ, 66.6% in microinvasive carcinoma of uterine cervix and 55.3% of 103 erosion findings was cervical intraepithelial neoplasia, carcinoma in situ or microinvasive carcinoma. 23.1% of cervical lesion were normal gross finding. Menopause was associated with false-negative rate and previous vaginal infection history, previous cervical minor operation, delivery mode, contraception method, pelvic inflammatory disease history, vaginal bleeding at Pap smear and gross finding of cerbix were not associated. There were no clinical factors that were associated with false-positive rate. CONCLUSION: Compared with other reports, false-negative rate(7.2%) and false-positive rate(4.6%) of Pap smear was lower and corresponding rate(88.2%) was higher in Hanyand university hospital. Because of higher false-negative rate in menopausal women, it need more careful to take and interpretate Pap smear in these group.
Adenomyosis
;
Carcinoma in Situ
;
Cervical Intraepithelial Neoplasia
;
Cervix Uteri
;
Contraception
;
Diagnosis
;
Female
;
Gynecology
;
Humans
;
Incidence
;
Leiomyoma
;
Mass Screening
;
Menopause
;
Mortality
;
Obstetrics
;
Pathology
;
Pelvic Inflammatory Disease
;
Retrospective Studies
;
Sensitivity and Specificity
;
Uterine Cervical Neoplasms
;
Uterine Hemorrhage
8.Significance of Interleukin-2(IL-2), Interleukin-6(IL-6), and Tumor Necrosis Factor-a(TNF-a) in the Ascites of Ovarian Cancer.
Young Oh KIM ; Kyung Tai KIM ; Jung Bae YOO ; Sam Hyun CHO ; Youn Yeoung HWANG ; Hyung MOON ; Jai Auk LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(1):1-13
Previous studies have shown that the cancer cell lines secrete multiple cytokines, such as macrophage colony-stimulating factor(M-CSF), granulocyte-macrophage colony stimulating factor(GM-CSF), interleukin-l(IL-1), interleukin-2(IL-2), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-alpha). We evaluated the levels of IL-2, IL-6, and TNF-alpha in the ascites of 23 patients with ovarian cancer. These levels were then compared with cytokine concentration found in 10 patients who had benign ascites and also studied the relation between levels of cytokines and clinical parameters. Enzyme-linked immunosorbent assay(ELISA) was used to determine the levels of cytokines in ascitic fluids. The median age of the group was 56, and the median follow-up time was 24 months. The levels of IL-2 was not elevated in ascites of ovarian cancer(30.5 vs 37.2 pg/ml, p=0.083), 1 he levels of TNF-alpha in the ascites with ovarian cancer were higher when compared with ascites of benign disease and was nearly approached statistically significant(91.0+/-20.7 vs 440.2+/-117.9pg/ml, p=0.058). Significantly higher IL-6 levels were detected in patients ascites compared with ascites with benign disease(354.3+/-42.9 vs 5,605+/-1,137pg/ml, p=0.006). IL-6 and TNF-a levels in ascites did not correlate statistically with tumor volume, histologic type or with survival time. IL-6 levels did not correlated statistically with volume of ascites. IL-6 and TNF-a levels did not correlated either. Circulating platelet counts in patients with ovarian cancer were significantly higher than in patients with benign conditions (282.6+/-5 vs 388.4+/-21.2x-10(9)/l, p=0.003). Thrombocytosis(platelet counts>400x10(9)/l) occured in 35%(8/23) of the cases with ovarian cancer. IL-6 levels in ascites correlated signi-ficantly with circulating platelet counts(R=0.427, p=0.042). This study showed that the patients with ovarian cancer have elevated levels of IL-6 in ascites. IL-6 levels were not correlate with disease status in patients with ovarian cancer. However, the correlation was found between IL-6 levels and thrombocytosis. This observation suggest a role for IL-6 in the development of tumor-associated thrombocytosis. A larger study would help in evaluating the potential biological roles and use of cytokines as tumor markers in ovarian cancer.
Ascites*
;
Ascitic Fluid
;
Blood Platelets
;
Cell Line
;
Cytokines
;
Follow-Up Studies
;
Humans
;
Interleukin-2
;
Interleukin-6
;
Macrophages
;
Necrosis*
;
Ovarian Neoplasms*
;
Platelet Count
;
Thrombocytosis
;
Tumor Burden
;
Biomarkers, Tumor
;
Tumor Necrosis Factor-alpha
9.An immunohistochemical evaluation of c-erbB-2 expression in epithelial ovarian cancer.
Kyung Tai KIM ; Sam Hyun CHO ; Youn Yeoung HWANG ; Hyung MOON ; Jai Auk LEE ; Young Hye KO ; Jung Dal LEE
Korean Journal of Obstetrics and Gynecology 1993;36(8):3334-3342
No abstract available.
Ovarian Neoplasms*
10.Clinical study of transabdominal cervico-isthmic cerclage operation in patiens with incompotent internal os of the cervix; preliminary results.
Moon Il PARK ; Ki Hun LEE ; Sung Ro CHUNG ; Jai Auk LEE ; Hyung MOON ; Doo Sang KIM
Korean Journal of Perinatology 1992;3(1):51-62
No abstract available.
Cervix Uteri*
;
Female