No abstract available.
Atropine* ; Hidrocystoma*

We compared cycloplegic refraction after convenient, less toxic single-dose atropinization with conventional three-day atropinization in esotropic children. We examined sixty children below eight years of age with esotropia. Their eyes were examined by cycloplegic refraction at 90 and 120 minutes after administering a drop of atropine twice at five minutes interval. After eight applications for three days, we performed cycloplegic refraction of their eyes. In the two groups, spherical equivalent and spherical power were statistically significantly different, and it had no statistical significance between the measurement of single-dose atropinization plus 0.5 diopter and three-day atropinization. The side effects were found lesser in single-dose application than conventional three-day applications. The results showed that single-dose atropinization can be substituted for conventional three-day atropinization in clinical practice.
Atropine ; Child* ; Esotropia ; Humans

We observed the change of serum cholinesterase and clinical symptoms of acute parathion intoxication in I.C.U. of N.M.C. from 1975 Sep. to 1976 Oct. The results were as follows; 1. Serum choinesterase level of control group (55 cases) was l00. 53+/-13. 8 and range was 74~125 unit. 2. Serum cholinesterase level were reduced markedly below 10 units in 10 cases of severe parathion intoxication. 3. With adequate treatment PAM & atropine, serum cholinesteraee level rose steadly from 3 rd hospital day to 7 th hospital day and thereafter marked rising was noted remarkable improvement of respiratory symptoms. 4. In cases of low serum cholinestrsse level, sudden aggravation of general symptoms even death occurred and the symptoms & signs were correlated serum cholinesterase level.
Atropine ; Cholinesterases* ; Clinical Study* ; Parathion*

Appropriate early atropinization is important for the recovery and prognosis of the organophosphate pesticides poisoning patient. However, recommended guidelines of atropine regimen in the treatment of organophosphate pesticides poisoning is not present in Korea. The authors analyzed the domestic literatures and books to investigate a trend of the regimen of atropine for organophosphate pesticides poisoning. We found 11 papers and 6 books about organophosphate pesticides poisoning that published in Korea. Then calculates elapsed time for atropinization by the each regimen of atropine. References recommendations varied markedly - atropinization of an average patient, requiring the mean dose of 23.4 mg, would have taken 15 to 432 minutes; atropinization of a very ill patient, requiring maximum dose of 75 mg, would have taken 20 to 1,385 min, Recently, it suggested atropine regimen that doubling the dose for organophosphate pesticides poisoning in Korea. So it needs to study for ensure a higher validity and application of organophosphate pesticides poisoning patients.
Atropine* ; Humans ; Korea ; Pesticides* ; Poisoning* ; Prognosis

In human volunteers, 0.25mg of atropine was given in divided doses(0.1mg and 0.15mg) with an interval of 15 minutes and 50 minutes When atropine was given with an interval of 15 minutes, the first dose (0.1mg) produced bardycardia and the second does caused slight increase of pulse rate which did not exceed the original rate. When atropine was given with an interval of 50 minutes, the first dose (0.1mg) produced bradycardia and the second dose marked increase of pulse rate which exceeded the original rate.
Atropine* ; Bradycardia ; Healthy Volunteers ; Heart Rate*

Cycloplegic refraction with 1% cyclopentolate and I % atropine was performed in esotropic children younger than 6 years. The purpose of this study was to find clinical factors related with differencs in refractive changes between cyclopentolate and atropine Additionally, the periodic refractive changes at the first, second and third day during performing traditional atropinization were evaluated. The results were as follows: The refractive state after using 1 % cyclopentolate was + 5.00 diopters in average and that after using 1% atropine was +5.77 diopters in average (patropine were higher by +1.50 or more diopters than those using cyclopentolate in one or both eyes. Factors increasing the differences in refractive change between atropine and cyclopentolate were hyperopia more than +4.00 diopters and young age less than 4 years but AC/A ratio was not related. The periodic refractive changes at the first, second, and third day during atropinization were statistically significant.
Atropine* ; Child* ; Cyclopentolate ; Esotropia ; Humans ; Hyperopia

The purpose of this study is to evaluate the applicability of intravenous atropine sulfate therapy in infantile hypertrophic pyloric stenosis (IHPS). From 1998 to 2000 among 35 cases of IHPS, pyloromytomy was performed in 13 (Group A), and intravenous atropine was given as a primary therapy in 22 cases (Group B). In group A, all cases were cured completely. In group B, 13 (59 %) out of 22 cases were successfully treated with atropine, but 9 were failed therapy, and required operation. The recovery period to normal feeding and the hospital stay of the successful atropine group were longer than those of pyloromyotomy, 8.6 days vs. 2.9 days and 13.2 days vs. 4.1 days, respectively. In conclusion, intravenous atropine therapy did not replace pyloromyotomy, but it might be an alternative for the selected patients with contraindications for operation.
Atropine* ; Humans ; Length of Stay ; Pyloric Stenosis, Hypertrophic*

The changes in the choroidal blood flow induced by the intravenously administered miotics (pilocarpine, 1mg/kg) and mydriatics(atropine, O.1mg/kg) were investigated in rabbits with the use of the blood flow measuring apparatus according to the principle of Grayson's internal calorimetry, thermistors as sensing elements. Atropine caused slow increase in the choroidal blood flow after transient decrease, the maximal increase being about 85% of the pre-injection level. Pilocarpine also produced moderate increase of the blood flow by more than 100% of the original level. From these data it is concluded that both atropine and pilocarpine caused significant increase in the choroidal blood flow in rabbit.
Atropine ; Calorimetry ; Choroid* ; Miotics ; Pilocarpine ; Rabbits*

The therapeutic applications of Soft Contact Lenses including its optical use are most popular, devices in Ophthalmological field. The presoaked soft contact lenses (Bionite Lens) by 1% pilocarpine,10% phenylnephrine. 1% homatropine, and 1% atropine for 4 minutes are inserted into the albino rabbit and the size of pupil was measured using mm. caliper under the dim red light in the dark room. Hourly measurements were carried out and were stopped in each subject when the pupil size of both eyes had returned to normal. The pupil size of control group, which only the above drug were instilled into the conjunctival cuI de sac, was also measured as the same method. As conclusion using soft contact lens in the therapeutic purpose, it potentiate the effect of medication and prolong the time of drug effect compared with the control groups.
Atropine ; Contact Lenses, Hydrophilic* ; Miotics* ; Mydriatics* ; Pupil

BACKGROUND: A question was whether it was preferable to give the reversal agent when profound block was present or wait for some spontaneous recovery before antagonizing the block. This study has been conducted to evaluate the reversal effects of neostigmine with divided doses in the rabbits after pancuronium when profound relaxation(PTC=O) or the first twitch of TOF stimulation was appeared (TOF,T1) was confirmed. METHODS: Rabbits(n=60) were randomly allocated to 5 groups. After pancuronium 0.2 mg/kg intravenously, spontaneous recovery was evaluated in group 1. When the profound relaxation(PTC=O) was confirmed at 5 min. after pancuronium, neostigmine 50 ug/kg with atropine 20 ug/kg were injected in group 2. At that time, neostigmine 10 ug/kg with atropine 4 ug/kg were injected and after 3 min. neostigmine 40 ug/kg with atropine 16 ug/kg were injected in group 3. When TOF, Tl was confirmed, neostigmine 50 ug/kg with atropine 20 ug/kg were injected in group 4. At that time, neostigmine and atropine were injected in group 5 as the same way of group 3. RESULTS: The mean time from injection of pancuronium to 95% recovery was 98.9 min. in group 1, 60.3 min. in group 2, 50.9 min. in group 3, 71.0 min. in group 4 and 67.1 min. in group 5. The recovery index was significantly reduced when neostigmine was injected at TOF,T1(p<0.05). The recovery time after neostigmine with divided doses was reduced, but there was no significant difference. CONCLUSIONS: The results of present study suggested that total recovery time was reduced when neostigmine was injected earlier with divided doses than single dose unrelated to profound relaxation.
Atropine ; Muscle Relaxation* ; Neostigmine* ; Pancuronium ; Rabbits* ; Relaxation