1.Effects of extra-corporeal shock waves on penile hemodynamics and histopathology in rats.
Ahmet TEFEKLI ; Abdullah ARMAGAN ; Bulent EROL ; Murat CELTIK ; Isi KILICASLAN ; Asiye NURTEN ; Ates KADIOGLU
Asian Journal of Andrology 2002;4(4):249-253
AIMTo study the effect of extra-corporeal shock wave (ESW) on the penile hemodynamics and histopathology in rats.
METHODSAdult male Sprague-Dawley rats were divided at random into 3 groups. ESW application was performed with a Siemens Lithostar with the rats under anesthesia lying prone on the balloon probe. Rats in Group I received a total of 1000 shocks at 18 kV and immediately underwent hemodynamic evaluation performed by direct electrostimulation of the cavernous nerve and measurement of intracavernous pressure (ICP). Rats in Group II received 3 times 1000 shocks at 18 kV at weekly intervals and hemodynamic evaluation was performed 1 month after the last ESW application. Group III served as the control. Histopathological examinations of penile tissues were done on Masson's trichrome and hematoxylin and eosin stained sections.
RESULTSPenile hemodynamic evaluation showed a trend toward a diminished mean maximal ICP, duration of erection, ICP during the plateau phase and maximal ICP/ blood pressure ratio in Group I, although there was no significant significance. The mean latency period in Groups I and II was prolonged. Petechial bleeding within tunical layers and small foci of hemorrhage within the corpora cavernosa were observed in Group I. However, histopathological examination failed to reveal any significant differences between the groups in terms of smooth muscle content, tunical thickness, organization of collagen bundles and elastic fiber-lattice framework.
CONCLUSIONESW has certain damaging effects on the penis.
Animals ; Blood Pressure ; radiation effects ; Electric Stimulation ; Hemodynamics ; High-Energy Shock Waves ; Male ; Penile Erection ; physiology ; radiation effects ; Penis ; blood supply ; innervation ; pathology ; radiation effects ; Rats ; Rats, Sprague-Dawley
2.Evaluation of gonadotropin-replacement therapy in male patients with hypogonadotropic hypogonadism.
Mazhar ORTAC ; Muhammed HIDIR ; Emre SALABAS ; Abubekir BOYUK ; Caner BESE ; Yasar PAZIR ; Ates KADIOGLU
Asian Journal of Andrology 2019;21(6):623-627
Hypogonadotropic hypogonadism (HH) is a rare disease in which medical treatment has a high success rate to achieve fertility. This study aimed to analyze the efficacy of hormone replacement therapy and determine predictive factors for successful spermatogenesis and spontaneous pregnancy in patients with idiopathic HH. A total of 112 patients with low testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and normal prolactin levels were diagnosed with HH and administered LH and FSH analogs as hormone replacement therapy. During treatment, 96 (85.7%) patients had sperm present in ejaculate samples. Among these patients, 72 were married and wanted a child. Of these 72 patients, 48 (66.7%) of couples had pregnancies from natural conception. After initiation of treatment, the mean time for the appearance of sperm in semen was 9.48 months. There were no significant differences between baseline FSH, T, and LH levels; however, older age, larger testicular size, and low rate of undescended testes were favorable factors for successful spermatogenesis. Larger testicular size and older age were also the main predictive factors for natural conception. We found that patients with undescended testes had a younger age, smaller testes, and lower T levels compared with patients exhibiting descended testes. The rate of sperm found in the ejaculate was not significantly decreased in patients with undescended compared with descended testis (73.7% vs 87.6%, P = 0.261). The medical approach for males with HH and azoospermia provides a successful treatment modality in regard to successful spermatogenesis and achievement of pregnancy.
Adolescent
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Adult
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Chorionic Gonadotropin/therapeutic use*
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Follicle Stimulating Hormone/therapeutic use*
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Gonadotropins/therapeutic use*
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Hormone Replacement Therapy/methods*
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Humans
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Hypogonadism/pathology*
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Luteinizing Hormone/therapeutic use*
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Male
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Middle Aged
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Retrospective Studies
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Spermatogenesis/drug effects*
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Young Adult