Patients with thalamic lesions can experience ataxia on the contralesional side. We report here a 24 year old female patient who presented with a left thalamic tumor and experienced bilateral ataxia of the upper and lower extremities after a left thalamic resection. Her right-sided ataxia was more severe than that of the left side. The bilateral ataxia was likely to be from cerebellar ataxia. The right-sided ataxia may have been caused by injury of the dentatorubrothalamic tract originating from the dentate nucleus of the right cerebellum and terminating in the contralateral ventrolateral nucleus of the left thalamus. We believe that the left sided ataxia in this patient was due to an uncrossed dentatorubrothalamic tract, which control the movement of the ipsilateral side of the human body.
Ataxia

Objective To investigate the role of specific imaging parameters in the clinical diagnosis and differential diagnosis of multiple system atrophy with predominant cerebellar ataxia （MSA-C）. Methods Imaging data including pontine volume were measured for 34 patients with MSA-C who were admitted to Department of Neurology， Shaanxi Provincial People’s Hospital， from January 2021 to October 2024， and these patients were compared with 9 patients with progressive supranuclear palsy （PSP）， 8 patients with spinocerebellar ataxia （SCA）， and 32 normal controls. Results There was a significant difference in pontine volume between the MSA-C group and the PSP group， as well as between the MSA-C group and the normal control group （P<0.008 3）， while there was no significant difference between the MSA-C group and the SCA group （P>0.008 3）. There was no significant difference in pontine volume between the PSP group and the SCA group and between the PSP group and the normal control group （P>0.008 3）， and there was a significant difference in pontine volume between the SCA group and the normal control group （P<0.008 3）. The receiver operating characteristic （ROC） curve analysis showed that pontine volume had a cut-off value of 8.66 cm3 in the diagnosis of MSA-C， with an area under the ROC curve （AUC） of 0.972， a sensitivity of 94.12%， and a specificity of 100%； pontine volume had a cut-off value of 8.66 cm3 in the differential diagnosis of MSA-C from PSP， with an AUC of 0.961， a sensitivity of 94.1%， and a specificity of 100%； pontine volume had a cut-off value of 6.79 cm3 in the differential diagnosis of MSA-C from SCA， with an AUC of 0.783， a sensitivity of 52.94%， and a specificity of 100%. Conclusion As the most objective indicator for evaluating pontine atrophy， pontine volume has a great significance in the diagnosis and differential diagnosis of MSA-C.
Ataxia

No abstract available.
Ataxia* ; Diagnosis*

No abstract available.
Apraxias* ; Ataxia*

No abstract available.
Ataxia* ; Ophthalmoplegia*

No abstract available.
Apraxias* ; Ataxia*

Dentatorubral-pallidoluysian atrophy（DRPLA） is a rare autosomal dominant neurodegenerative disease caused by CAG triplet expansion in the atrophin 1 （ATN1） gene. Up to now， the pathogenesis of DRPLA remains unclear. The main clinical features of DRPLA include myoclonus， epilepsy， ataxia， choreoathetosis， and cognitive impairment. DRPLA has great clinical heterogeneity， and the number of CAG repeats is negatively correlated with age of onset and disease severity. Some patients with late-onset DRPLA may have atypical manifestations without typical imaging changes， which brings challenges to the diagnosis of the disease. This article reviews the pathogenesis， pathological features， clinical and imaging manifestations， diagnosis， and potential treatment of DRPLA， in order to deepen the understanding of this disease.
Ataxia ; Myoclonus

Progressive ataxia and palatal tremor (PAPT) is a subgroup of symptomatic palatal tremors which is characterized by palatal tremor and idiopathic progressive cerebellar ataxia. Here, we report a 59 year-old-male who presented with a 5 months history of progressive cerebellar ataxia, and was discovered to have both a symptomatic palatal tremor and torsional nystagmus. Various studies searching for the cause of the ataxia and the palatal tremor all came out negative, thus defining this patient as a PAPT.
Ataxia* ; Cerebellar Ataxia ; Humans ; Tremor*

No abstract available.
Ataxia* ; Atrophy* ; Cerebellar Ataxia ; Spinocerebellar Ataxias*

No abstract available.
Ataxia* ; Cerebellar Ataxia ; Infarction* ; Middle Cerebral Artery*